Abstract: A method for monitoring power consumption of an appliance within a space is provided. The method includes obtaining a first set of data indicative of power consumption of the appliance during an interval of time and determining a profile indicative of power consumption of the appliance based, at least in part, on the first set of data. The method includes obtaining a second set of data indicative of power consumption of the appliance subsequent to obtaining the first set of data. The method includes determining whether power consumption of the appliance deviates from the profile based, at least in part, on the second set of data. Furthermore, in response to determining power consumption of the appliance deviates from the profile, the method includes providing a notification indicative of power consumption of the appliance deviating from the profile.

Abstract: A method for monitoring power consumption of an appliance within a space is provided. The method includes obtaining a first set of data indicative of power consumption of the appliance during an interval of time and determining a profile indicative of power consumption of the appliance based, at least in part, on the first set of data. The method includes obtaining a second set of data indicative of power consumption of the appliance subsequent to obtaining the first set of data. The method includes determining whether power consumption of the appliance deviates from the profile based, at least in part, on the second set of data. Furthermore, in response to determining power consumption of the appliance deviates from the profile, the method includes providing a notification indicative of power consumption of the appliance deviating from the profile.

Abstract: A collection of methods for monitoring the operation of a heating system configured to heat a space is provided. One method includes obtaining, by one or more computing devices, data from a fuel sensor for a period of time, the fuel sensor configured to detect an amount of fuel within a fuel supply for a furnace of the heating system. The method further includes determining, by the one or more computing devices, an adjustment to the operation of the heating system based, at least in part, on the data obtained from the fuel sensor. The method additionally includes adjusting, by the one or more computing devices, the operation of the heating system according to the adjustment.

Abstract: A method for monitoring power consumption of an appliance within a space is provided. The method includes obtaining a first set of data indicative of power consumption of the appliance during an interval of time and determining a profile indicative of power consumption of the appliance based, at least in part, on the first set of data. The method includes obtaining a second set of data indicative of power consumption of the appliance subsequent to obtaining the first set of data. The method includes determining whether power consumption of the appliance deviates from the profile based, at least in part, on the second set of data. Furthermore, in response to determining power consumption of the appliance deviates from the profile, the method includes providing a notification indicative of power consumption of the appliance deviating from the profile.

Abstract: A method for monitoring power consumption of an appliance within a space is provided. The method includes obtaining a first set of data indicative of power consumption of the appliance during an interval of time and determining a profile indicative of power consumption of the appliance based, at least in part, on the first set of data. The method includes obtaining a second set of data indicative of power consumption of the appliance subsequent to obtaining the first set of data. The method includes determining whether power consumption of the appliance deviates from the profile based, at least in part, on the second set of data. Furthermore, in response to determining power consumption of the appliance deviates from the profile, the method includes providing a notification indicative of power consumption of the appliance deviating from the profile.

Abstract: A luminaire may include a universal translator and interface system. The universal translator and interface system may include one or more universal interfaces that are configured to removably and communicably couple one or more control devices and/or a building lighting control system to the luminaire. Further, the universal translator and interface system may include a universal translator engine that is communicably coupled to the one or more universal interfaces. The universal translator engine is configured to translate data in a first format associated with a first communication protocol to a second format associated with a second communication protocol to enable interoperability between the control devices, the building lighting control system, and the luminaire that may have different communication protocols that are incompatible with each other.

Abstract: A method is provided which facilitates and enables the production of a wide range of complex conjugates composed of similar or dissimilar units linked together by amide bonds. Said method for the production of acylthio derivatives, R′—CO—SA, involves reaction of a carboxylate, R′—CO—O− (or carboxylic acid R′—CO—OH) with an iso-thiouronium derivative (bearing SA) in the presence of base. Nucleophilic counterion forms of the iso-thiouronium salts confer significant rate enhancement. The processes are simple, generally applicable, efficient, and do not require the employment of noxious reagents. The production of complex protein-like products by the intermediary of acylthio esters generated by the process of this invention, provides a method which is compatible with mild methods of chain assembly; and is preferably applied when the second component in the ligation bears an amino terminal cysteine residue.

Abstract: Polyolefin particles are chemically modified by oxidation to provide a large surface area and high loading. The particles result in low back pressure in column systems, and are economical to manufacture. The particles are useful as supports in a wide range of applications including general organic as well as biopolymer synthesis, library methods, purification processes and enzyme mediated processes. In a preferred embodiment, polyethylene or polypropylene particles are oxidized in a solution containing trifluoroacetic acid or trifluoromethane sulfonic acid, chromium trioxide and sulfuric acid to provide the particles with a chemically reactive irregular surface and open channels that extend below the surface and up to essentially the length of the radius of the particles resulting in increased surface area and decreased density. The particles have pendant functional groups produced by the oxidation and/or by subsequent chemical reaction.

Abstract: Compositions and methods for identifying compositions which inhibit binding of the Rev protein to the Rev-responsive element in cells infected by HIV-1 are provided. The compositions display or mimic the electronic configuration of a binding domain within the native Rev protein, but are free from those portions responsible for REV activity and are preferably modified to display enhanced binding affinity to the RRE. Screening methods for identifying polypeptides and other compositions having such enhanced binding affinity are also described.

Abstract: Method and apparatus for simple and rapid preparation of reusable, addressable surface-immobilized arrays of biomolecules (libraries) used for screening for interaction with any biologically significant target. A special plate having on its surface a plurality of discreet functionalized substrate areas, typically in arrays of 10.times.10 to 400.times.400, is provided for chemical synthesis or bonding thereon of desired families of biomolecules (e.g. peptides, DNA, RNA, oligosaccharides). In the case of peptides, such as hexapeptides, the resulting permanently hexapeptide-loaded plate is a reusable Addressable Synthetic Peptide Combinatorial Library (ASPCL), in which 1 to 3 (typically two) of the positions in the sequence are uniquely identified by the address location. Plate embodiments include substrates of physically bonded (e.g.

Abstract: Method and apparatus for simple and rapid preparation of reusable, addressable surface-immobilized arrays of biomolecules (libraries) used for screening for interaction with any biologically significant target. A special plate having on or in its surface a plurality of discreet functionalized substrate areas, typically in arrays of 10.times.10 to 400.times.400, is provided for chemical synthesis or bonding thereon of desired families of biomolecules (e.g. peptides, DNA, RNA, oligosaccharides). In the case of peptides, such as hexapeptides, the resulting permanently hexapeptide-loaded plate is a reusable Addressable Synthetic Peptide Combinatorial Library (ASPCL), in which 1 to 3 (typically two) of the positions in the sequence are uniquely identified by the address location. The preferred plate embodiment employs an HPMP wink of porous polyolefin removably received in holes in the plate. A unique multi-slot block assembly is used to prepare the ASPCLs.

Abstract: The invention relates to methods and systems of unhindered construction and display of tethered organic ligand molecules, and more particularly to preparation and use of thin film, substantially non-crosslinked hydrophilic polar multi-functionalized polymers (HPMPs) anchored to a variety of functionalized substrates so that the HPMP forms a thin film matrix layer providing a unique highly hydrated, high dielectric environment equivalent to an aqueous solution, for affinity binding of Ligands (L) to Tagged Target Molecules (TTMs). Ligands, and especially MER.sub.n ligand libraries such as peptide libraries, are singly tethered to the HPMP by a "permanent" strong covalent bond so that subsequent displacement of the TTM does not also displace the ligand from the HPMP, thereby making the HPMP tethered Ligand library reusable. The HPMP thin film is on the order of 200-2000 .ANG.

Abstract: Derivatives of 1-phenyl pyrazolin-5-one have many applications for biomolecule synthesis. Enol esters of protected amino acids made by the present process provide efficient coupling in solid-phase peptide synthesis. The 1-phenyl-pyrazolin-5-one derivatives are highly crystalline, stable, non-toxic and easy to prepare. Many possess self-indicating properties, facilitating spectrophotometric monitoring and automation of peptide synthesis.

Abstract: A chemical processing system is disclosed for the automated dissolution, dispersing and reaction of chemicals, especially for synthesizing proteins. The system includes a plurality of storage cartridges containing a first chemical in fluid communication with a reservoir containing a second chemical to be reacted with the first chemical. Each cartridge includes a pump (e.g., a plunger) which operates by changing the internal volume of the cartridge. The pump permits bi-directional flow of the first chemical into and out of the reservoir and cartridge to promote mixing and reacting with the second chemical in the reservoir to produce a third chemical.

Abstract: Trialkoxybenzyl (Taob) protected asparagine and glutamine, a method of synthesis and a method of use are provided. The Taob protected Asn and Gln have the following formulae: ##STR1## wherein Z is an alkyl group having from 1 to 10 carbon atoms; X and W are any .alpha.-protecting group which can be selectively removed while maintaining Taob intact; Y is H or any group sufficiently active or activatable to react with NH.sub.2 -- or NH.dbd. to generate an amide bond; n is 1 for asparagine or 2 for glutamine. These derivatives are stable in solution, have good solubility in organic solvents and couple directly without side reactions.

Abstract: A novel method of activation of a protected amino acid using Benzotriazolyloxytris(dimethylamino)phosphonium Hexafluorophosphate (BOP) as an activator for solid phase peptide synthesis is provided. Hydroxybenzotriazole is included in preferred embodiments. An intermediate acyloxyphosphonium salt is formed from the protected amino acid and the BOP which immediately reacts with HOBt to form an ester without formation of the less reactive symmetrical anhydride. A tertiary or quaternary substituted nitrogen compound must be used to produce a carboxylate of the protected amino acids as it also functions to increase their solubility.

Abstract: Benzazoles, including benzatriazoles and benzimidazoles are employed in phospate triester oligonucleotide synthesis. The benzazoles form arylbenzazolide coupling agents, and phosphorodibenzazolides. Processes employing these reagents are also disclosed.

Abstract: Benzotriazoles are employed in phosphite triester oligonucleotide synthesis. The benzotriazoles also form phosphinedibenzazolides. Processes employing these reagents are also disclosed.

Abstract: Compounds corresponding in structure to enkephalin or polypeptide analogues thereof, wherein one or more peptide links of the enkephalin or analogue is represented by a group or groups the same or different selected from dimethylene, hydroxydimethylene, methylene-imino and ketomethylene groups and/or wherein adjacent peptide bond nitrogen atoms are linked by a carbonyl or thiocarbonyl group.

Abstract: Compounds corresponding in structure to enkephalin or polypeptide analogues thereof, wherein one or more peptide links of the enkephalin or analogue is represented by a group or groups the same or different selected from dimethylene, methylene-imino and keto-methylene groups.