Patents by Inventor Derek Hudson

Derek Hudson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6277957
    Abstract: A method is provided which facilitates and enables the production of a wide range of complex conjugates composed of similar or dissimilar units linked together by amide bonds. Said method for the production of acylthio derivatives, R′—CO—SA, involves reaction of a carboxylate, R′—CO—O− (or carboxylic acid R′—CO—OH) with an iso-thiouronium derivative (bearing SA) in the presence of base. Nucleophilic counterion forms of the iso-thiouronium salts confer significant rate enhancement. The processes are simple, generally applicable, efficient, and do not require the employment of noxious reagents. The production of complex protein-like products by the intermediary of acylthio esters generated by the process of this invention, provides a method which is compatible with mild methods of chain assembly; and is preferably applied when the second component in the ligation bears an amino terminal cysteine residue.
    Type: Grant
    Filed: March 23, 2000
    Date of Patent: August 21, 2001
    Inventors: Derek Hudson, Stewart Thompson
  • Patent number: 5679539
    Abstract: Polyolefin particles are chemically modified by oxidation to provide a large surface area and high loading. The particles result in low back pressure in column systems, and are economical to manufacture. The particles are useful as supports in a wide range of applications including general organic as well as biopolymer synthesis, library methods, purification processes and enzyme mediated processes. In a preferred embodiment, polyethylene or polypropylene particles are oxidized in a solution containing trifluoroacetic acid or trifluoromethane sulfonic acid, chromium trioxide and sulfuric acid to provide the particles with a chemically reactive irregular surface and open channels that extend below the surface and up to essentially the length of the radius of the particles resulting in increased surface area and decreased density. The particles have pendant functional groups produced by the oxidation and/or by subsequent chemical reaction.
    Type: Grant
    Filed: January 24, 1995
    Date of Patent: October 21, 1997
    Inventors: Derek Hudson, Ronald M. Cook
  • Patent number: 5654398
    Abstract: Compositions and methods for identifying compositions which inhibit binding of the Rev protein to the Rev-responsive element in cells infected by HIV-1 are provided. The compositions display or mimic the electronic configuration of a binding domain within the native Rev protein, but are free from those portions responsible for REV activity and are preferably modified to display enhanced binding affinity to the RRE. Screening methods for identifying polypeptides and other compositions having such enhanced binding affinity are also described.
    Type: Grant
    Filed: June 3, 1993
    Date of Patent: August 5, 1997
    Assignee: The Regents of the University of California
    Inventors: Alan Frankel, Ruoying Tan, Derek Hudson
  • Patent number: 5591646
    Abstract: Method and apparatus for simple and rapid preparation of reusable, addressable surface-immobilized arrays of biomolecules (libraries) used for screening for interaction with any biologically significant target. A special plate having on its surface a plurality of discreet functionalized substrate areas, typically in arrays of 10.times.10 to 400.times.400, is provided for chemical synthesis or bonding thereon of desired families of biomolecules (e.g. peptides, DNA, RNA, oligosaccharides). In the case of peptides, such as hexapeptides, the resulting permanently hexapeptide-loaded plate is a reusable Addressable Synthetic Peptide Combinatorial Library (ASPCL), in which 1 to 3 (typically two) of the positions in the sequence are uniquely identified by the address location. Plate embodiments include substrates of physically bonded (e.g.
    Type: Grant
    Filed: September 2, 1992
    Date of Patent: January 7, 1997
    Assignee: Arris Pharmaceutical
    Inventors: Derek Hudson, Charles R. Johnson, Lutz Giebel
  • Patent number: 5585275
    Abstract: Method and apparatus for simple and rapid preparation of reusable, addressable surface-immobilized arrays of biomolecules (libraries) used for screening for interaction with any biologically significant target. A special plate having on or in its surface a plurality of discreet functionalized substrate areas, typically in arrays of 10.times.10 to 400.times.400, is provided for chemical synthesis or bonding thereon of desired families of biomolecules (e.g. peptides, DNA, RNA, oligosaccharides). In the case of peptides, such as hexapeptides, the resulting permanently hexapeptide-loaded plate is a reusable Addressable Synthetic Peptide Combinatorial Library (ASPCL), in which 1 to 3 (typically two) of the positions in the sequence are uniquely identified by the address location. The preferred plate embodiment employs an HPMP wink of porous polyolefin removably received in holes in the plate. A unique multi-slot block assembly is used to prepare the ASPCLs.
    Type: Grant
    Filed: June 18, 1993
    Date of Patent: December 17, 1996
    Assignee: Arris Pharmaceutical Corporation
    Inventors: Derek Hudson, Charles R. Johnson, Lutz Giebel
  • Patent number: 5576220
    Abstract: The invention relates to methods and systems of unhindered construction and display of tethered organic ligand molecules, and more particularly to preparation and use of thin film, substantially non-crosslinked hydrophilic polar multi-functionalized polymers (HPMPs) anchored to a variety of functionalized substrates so that the HPMP forms a thin film matrix layer providing a unique highly hydrated, high dielectric environment equivalent to an aqueous solution, for affinity binding of Ligands (L) to Tagged Target Molecules (TTMs). Ligands, and especially MER.sub.n ligand libraries such as peptide libraries, are singly tethered to the HPMP by a "permanent" strong covalent bond so that subsequent displacement of the TTM does not also displace the ligand from the HPMP, thereby making the HPMP tethered Ligand library reusable. The HPMP thin film is on the order of 200-2000 .ANG.
    Type: Grant
    Filed: February 19, 1993
    Date of Patent: November 19, 1996
    Assignee: Arris Pharmaceutical Corporation
    Inventors: Derek Hudson, Charles R. Johnson, Michael J. Ross, Kevin R. Shoemaker, Robert T. Cass, Lutz B. Giebel
  • Patent number: 5233044
    Abstract: Derivatives of 1-phenyl pyrazolin-5-one have many applications for biomolecule synthesis. Enol esters of protected amino acids made by the present process provide efficient coupling in solid-phase peptide synthesis. The 1-phenyl-pyrazolin-5-one derivatives are highly crystalline, stable, non-toxic and easy to prepare. Many possess self-indicating properties, facilitating spectrophotometric monitoring and automation of peptide synthesis.
    Type: Grant
    Filed: September 26, 1991
    Date of Patent: August 3, 1993
    Assignee: Millipore Corporation
    Inventor: Derek Hudson
  • Patent number: 5147608
    Abstract: A chemical processing system is disclosed for the automated dissolution, dispersing and reaction of chemicals, especially for synthesizing proteins. The system includes a plurality of storage cartridges containing a first chemical in fluid communication with a reservoir containing a second chemical to be reacted with the first chemical. Each cartridge includes a pump (e.g., a plunger) which operates by changing the internal volume of the cartridge. The pump permits bi-directional flow of the first chemical into and out of the reservoir and cartridge to promote mixing and reacting with the second chemical in the reservoir to produce a third chemical.
    Type: Grant
    Filed: April 29, 1988
    Date of Patent: September 15, 1992
    Assignee: Millipore Corporation
    Inventors: Derek Hudson, Jordan Honig, Ronald M. Cook, Douglas J. Ng
  • Patent number: 4935536
    Abstract: Trialkoxybenzyl (Taob) protected asparagine and glutamine, a method of synthesis and a method of use are provided. The Taob protected Asn and Gln have the following formulae: ##STR1## wherein Z is an alkyl group having from 1 to 10 carbon atoms; X and W are any .alpha.-protecting group which can be selectively removed while maintaining Taob intact; Y is H or any group sufficiently active or activatable to react with NH.sub.2 -- or NH.dbd. to generate an amide bond; n is 1 for asparagine or 2 for glutamine. These derivatives are stable in solution, have good solubility in organic solvents and couple directly without side reactions.
    Type: Grant
    Filed: February 27, 1989
    Date of Patent: June 19, 1990
    Assignee: Millipore Corporation
    Inventor: Derek Hudson
  • Patent number: 4888385
    Abstract: A novel method of activation of a protected amino acid using Benzotriazolyloxytris(dimethylamino)phosphonium Hexafluorophosphate (BOP) as an activator for solid phase peptide synthesis is provided. Hydroxybenzotriazole is included in preferred embodiments. An intermediate acyloxyphosphonium salt is formed from the protected amino acid and the BOP which immediately reacts with HOBt to form an ester without formation of the less reactive symmetrical anhydride. A tertiary or quaternary substituted nitrogen compound must be used to produce a carboxylate of the protected amino acids as it also functions to increase their solubility.
    Type: Grant
    Filed: April 30, 1987
    Date of Patent: December 19, 1989
    Assignee: Millipore Corporation
    Inventor: Derek Hudson
  • Patent number: 4474947
    Abstract: Benzazoles, including benzatriazoles and benzimidazoles are employed in phospate triester oligonucleotide synthesis. The benzazoles form arylbenzazolide coupling agents, and phosphorodibenzazolides. Processes employing these reagents are also disclosed.
    Type: Grant
    Filed: April 8, 1982
    Date of Patent: October 2, 1984
    Assignee: Biosearch
    Inventors: Derek Hudson, Ronald M. Cook
  • Patent number: 4474948
    Abstract: Benzotriazoles are employed in phosphite triester oligonucleotide synthesis. The benzotriazoles also form phosphinedibenzazolides. Processes employing these reagents are also disclosed.
    Type: Grant
    Filed: April 8, 1982
    Date of Patent: October 2, 1984
    Assignee: Biosearch
    Inventors: Derek Hudson, Ronald M. Cook
  • Patent number: 4304715
    Abstract: Compounds corresponding in structure to enkephalin or polypeptide analogues thereof, wherein one or more peptide links of the enkephalin or analogue is represented by a group or groups the same or different selected from dimethylene, hydroxydimethylene, methylene-imino and ketomethylene groups and/or wherein adjacent peptide bond nitrogen atoms are linked by a carbonyl or thiocarbonyl group.
    Type: Grant
    Filed: January 14, 1980
    Date of Patent: December 8, 1981
    Inventors: Derek Hudson, Robert Sharpe, Michael Szelke
  • Patent number: 4198398
    Abstract: Compounds corresponding in structure to enkephalin or polypeptide analogues thereof, wherein one or more peptide links of the enkephalin or analogue is represented by a group or groups the same or different selected from dimethylene, methylene-imino and keto-methylene groups.
    Type: Grant
    Filed: July 10, 1978
    Date of Patent: April 15, 1980
    Inventors: Derek Hudson, Robert Sharpe, Michael Szelke
  • Patent number: RE30731
    Abstract: Compounds corresponding in structure to enkephalin or polypeptide analogues thereof, wherein one or more peptide links of the enkephalin or analogue is represented by a group or groups the same or different selected from dimethylene, methylene-imino and keto-methylene groups.
    Type: Grant
    Filed: August 14, 1980
    Date of Patent: September 1, 1981
    Inventors: Derek Hudson, Robert Sharpe, Michael Szelke