Patents by Inventor Derek J. Hoelz

Derek J. Hoelz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR ENHANCING EFFICACY AND SELECTIVITY OF CANCER CELL KILLING BY DNA DAMAGING AGENTS
    Publication number: 20150065444
    Abstract: The invention relates to the treatment of cancer using DNA damaging agents. The invention provides methods for treating a mammal with cancer, the method comprising inhibiting in the mammal acidic residue methyltransferase (Arm1) in combination with administering to the mammal a DNA damaging agent. The invention further provides pharmaceutical formulations comprising an inhibitor of acidic residue methyltransferase (Arm1) and a DNA damaging agent.
    Type: Application
    Filed: August 7, 2014
    Publication date: March 5, 2015
    Inventor: Derek J. HOELZ
  • METHOD FOR ENHANCING EFFICACY AND SELECTIVITY OF CANCER CELL KILLING BY DNA DAMAGING AGENTS
    Publication number: 20130177546
    Abstract: The invention relates to the treatment of cancer using DNA damaging agents. The invention provides methods for treating a mammal with cancer, the method comprising inhibiting in the mammal acidic residue methyltransferase (Arm1) in combination with administering to the mammal a DNA damaging agent. The invention further provides pharmaceutical formulations comprising an inhibitor of acidic residue methyltransferase (Arm1) and a DNA damaging agent.
    Type: Application
    Filed: February 28, 2012
    Publication date: July 11, 2013
    Applicant: MAINE INSTITUTE FOR HUMAN GENETICS AND HEALTH
    Inventor: Derek J. Hoelz
  • PCNA METHYLTRANSFERASE
    Publication number: 20120258482
    Abstract: Proliferating cell nuclear antigen (PCNA)-dependent glutamate methyltransferases are disclosed that can methylesterify one or more glutamic acid or aspartic acid residues of PCNA.
    Type: Application
    Filed: October 7, 2010
    Publication date: October 11, 2012
    Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
    Inventors: Derek J. Hoelz, Robert J. Hickey, Linda H. Malkas
  • csPCNA Isoform Modifications And Uses Thereof
    Publication number: 20110195510
    Abstract: Methods and compositions to detect the presence of csPCNA isoform by identifying one or more posttranslational modifications are disclosed. Methods to identify csPCNA isoform through posttranslational modifications including methylesterification levels are disclosed.
    Type: Application
    Filed: March 11, 2011
    Publication date: August 11, 2011
    Applicant: Indiana University Research and Technology Corporation
    Inventors: Derek J. HOELZ, Robert J. HICKEY, Linda H. MALKAS
  • csPCNA isoform modifications and uses thereof
    Patent number: 7932023
    Abstract: Methods and compositions to detect the presence of csPCNA isoform by identifying one or more posttranslational modifications are disclosed. Methods to identify csPCNA isoform through posttranslational modifications including methylesterification levels are disclosed.
    Type: Grant
    Filed: June 26, 2006
    Date of Patent: April 26, 2011
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Derek J. Hoelz, Robert J. Hickey, Linda H. Malkas
  • METHOD FOR PURIFYING CANCER-SPECIFIC PROLIFERATING CELL NUCLEAR ANTIGEN
    Publication number: 20100240874
    Abstract: An isolated antibody that binds a cancer specific Proliferating Cell Nuclear Antigen (csPCNA) that binds to the amino acid sequence LeuLysGlnLeuAspAlaGlnGlnThrGlnLeuArgIle AspSerPhePheArgLeuAlaGlnGlnGluLysGluAspAlaLysArg (SEQ ID No. 1). An immunoassay that utilizes an isolated antibody that binds a form of csPCNA that binds to the SEQ ID No. 1 to identify the presence of csPCNA in a sample.
    Type: Application
    Filed: May 25, 2010
    Publication date: September 23, 2010
    Inventors: LINDA H. MALKAS, ROBERT J. HICKEY, PAMELA E. BECHTEL, MIN PARK, DEREK J. HOELZ, DRAGANA TOMIC, LAUREN SCHNAPER
  • Method for purifying cancer-specific proliferating cell nuclear antigen
    Patent number: 7723487
    Abstract: The method for developing an antibody that exclusively binds to csPCNA.
    Type: Grant
    Filed: November 13, 2007
    Date of Patent: May 25, 2010
    Assignee: CS-KEYS, Inc.
    Inventors: Linda H. Malkas, Robert J. Hickey, Pamela E. Bechtel, Min Park, Derek J. Hoelz, Dragana Tomic, Lauren Schnaper
  • CSPCNA ISOFORM MODIFICATIONS AND USES THEREOF
    Publication number: 20090061432
    Abstract: Methods and compositions to detect the presence of csPCNA isoform by identifying one or more posttranslational modifications are disclosed. Methods to identify csPCNA isoform through posttranslational modifications including methylesterification levels are disclosed.
    Type: Application
    Filed: June 26, 2006
    Publication date: March 5, 2009
    Inventors: Derek J. Hoelz, Robert J. Hickey, Linda H. Malkas
  • Method for purifying cancer-specific proliferating cell nuclear antigen
    Publication number: 20080220540
    Abstract: The method for developing an antibody that exclusively binds to csPCNA.
    Type: Application
    Filed: November 13, 2007
    Publication date: September 11, 2008
    Inventors: Linda H. Malkas, Robert J. Hickey, Pamela E. Bechtel, Min Park, Derek J. Hoelz, Dragana Tomic, Lauren Schnaper
  • Method for purifying cancer-specific proliferating cell nuclear antigen
    Patent number: 7294471
    Abstract: A method for purifying cancer-specific Proliferating Cell Nuclear Antigen (csPCNA) is described, as well as an immunoassay based thereon.
    Type: Grant
    Filed: February 27, 2002
    Date of Patent: November 13, 2007
    Assignee: csKeys, LLC
    Inventors: Linda H. Malkas, Robert J. Hickey, Pamela E. Bechtel, Min Park, Derek J. Hoelz, Dragana Tomic, Lauren Schnaper
  • Method for purifying cancer-specific proliferating cell nuclear antigen
    Publication number: 20030162233
    Abstract: A method for purifying cancer-specific Proliferating Cell Nuclear Antigen (csPCNA) is described, as well as an immunoassay based thereon.
    Type: Application
    Filed: February 27, 2002
    Publication date: August 28, 2003
    Inventors: Linda H. Malkas, Robert J. Hickey, Pamela E. Bechtel, Lauren Schnaper, Min Park, Derek J. Hoelz, Dragana Tomic