Abstract: The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.

Abstract: The present disclosure relates to non-naturally occurring monooxygenase polypeptides useful for preparing prazole compounds, polynucleotides encoding the polypeptides, and methods of using the polypeptides.

Abstract: The present disclosure provides engineered transaminase polypeptides having improved properties as compared to naturally occurring transaminases including the ability of converting the substrate, 3?-hydroxyacetophenone to (S)-3-(1-aminoethyl)-phenol in enantiomeric excess and high percentage conversion. Also provided are polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to synthesize (S)-3-(1-aminoethyl)-phenol and related compounds useful in the production of active pharmaceutical ingredients.

Abstract: The present invention provides endoglucanase 1b (EG1b) variants suitable for use in saccharification reactions. The present application further provides genetically modified fungal organisms that produce EG1b variants, as well as enzyme mixtures exhibiting enhanced hydrolysis of cellulosic material to fermentable sugars, enzyme mixtures produced by the genetically modified fungal organisms, and methods for producing fermentable sugars from cellulose using such enzyme mixtures.

Abstract: The present disclosure provides engineered transaminase polypeptides having improved properties as compared to naturally occurring transaminases including the ability of converting the substrate, 3?-hydroxyacetophenone to (S)-3-(1-aminoethyl)-phenol in enantiomeric excess and high percentage conversion. Also provided are polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to synthesize (S)-3-(1-aminoethyl)-phenol and related compounds useful in the production of active pharmaceutical ingredients.

Abstract: The present disclosure relates to engineered ketoreductase polypeptides for the preparation of hydroxyl substituted carbamate compounds, and polynucleotides, vectors, host cells, and methods of making and using the ketoreductase polypeptides.

Abstract: An adjustable roof platform includes a panel having a top surface and a bottom surface. A peripheral wall is attached to and extends downward from the bottom surface of the panel. A front elongated member, a rear elongated member, a first side elongated member and second side elongated member are coupled together to define a frame base. The rear elongated member is hingedly coupled to the peripheral wall such that a bottom edge of the peripheral wall may be selectively positioned abutted against or positioned away from the first side, second side and front elongated members. A pair of supports selectively supports the panel in an angular relationship with respect to the frame base. A plurality of foot members is attached to a lower surface of the frame base. Each of the foot members comprises a non-skid material.

Abstract: Memory chips with data memory (202), embedded logic (206) and broadcast memory (204) for two modes of operation are disclosed. A first mode of operation is the usual memory mode expected of a data RAM. The second mode of operation allows localized computation and/or processing of the data in data memory (202) by the embedded logic (206) with minimal handshaking with a remote CPU. In a functioning system, the memory chips are organized in a hierarchical manner and include address-associative memory systems.

Abstract: A vehicle cab with a roof hatch (12) which comprises front and rear hatch sections (14) and (16), the rear section (14) being over an escape hatchway (26) and the front section (16) being over an equipment access hatchway (28) of a roof compartment. The front hatch section (16) is mounted on a front roof section (10a) along its forward edge by hinges (18), and releasably latched to a middle roof section (10c) along its rearward edge by secondary latches (22). The rear hatch section (14) is mounted on the rearward edge of the front hatch section (16) by hinges (20), and releasably latched to the rear roof section (10b) by a primary latch (40). The primary catch (40) may be released and the rear hatch section (14) may be partially opened and retained with rear stays (64) to provide ventilation. The rear stays (64) may then be automatically released when the rear hatch section (14) is pushed past the retention point to fully open the escape hatchway (26).

Abstract: Preferred embodiments include systems with neural network processors (58) having input encoders (56) that encode integers as binary vectors so that close integers encode as close binary vectors by requiring adjacent integers have encoded binary vectors that differ in a fixed fraction of their bits.

Abstract: An hydraulic unloading valve for unloading hydraulic fluid from a circuit pressurized by a diesel engine powered pump under cold climate conditions to assist starting of the engine. The valve has an inlet through which fluid enters the valve, an outlet through which fluid may leave the valve, an outlet valve seat, a valve member movable towards and away from the valve seat and carrying a valve surface for closing off the seat valve, a first orifice sensitive to viscosity which in response to the flow of fluid through the inlet generates a first pressure drop arranged to tend to move the valve member away from the valve seat, and second orifice which is not sensitive to viscosity and which in response to said flow generates a second pressure drop arranged to tend to move the valve towards the valve seat to bring the valve seat and surface into contact to close-off through the valve outlet when the second pressure drop is greater than the first pressure drop.

Abstract: A lever mechanism (10) suitably, amongst other uses, for use in the control of tractor draft links (22) from a location remote from the tractor operators station.The lever mechanism includes an operating member (40), a support (43) relative to which said operating member is displaceable (Z), a lever (42) pivotally mounted on the support about a pivot axis (44) which is also translationally moveable (X), a first formation (56) on the lever, a second formation (57) on the operating member, and bias means (53) acting to translationally move the lever on its axis (44) away from the second formation (57) to hold the first and second formations (56,57) disengaged when the lever is released.

Abstract: A control lever arrangement (10) for longitudinally moving an actuating member such as a Bowden cable (11) between first and second positions. The arrangement includes first (13) and second (14) mutually inclined cam slots and a control lever (15) which has a handle at one end and which is pivotally mounted (20) at the other end on a follower (16) for engagement with the first cam slot. The lever (15) carries guidance means (17) for engagement with the second cam slot and is connected (21) with the actuations member (11), so that, as the control lever is rotated (X1,X2) about its mounting (20) on the follower (16) to move the actuating member between its first and second positions, the follower moves along the first (13) cam slot as the guidance means (17) moves along the second cam slot (14) and the point of contact of the follower (16) with the first slot (13) moves across the line of action (33) of the actuating member (11) so that the lever goes over-center.