Abstract: Disclosed are chimeric antigen receptor (CAR) polypeptides comprising a T cell receptor (TCR) antigen binding domain, a transmembrane domain, and an intracellular signaling domain.

Abstract: Disclosed are methods of treating venous thromboembolism (VTE) in a subject, the method comprising administering a venous thrombus size lowering therapy to the subject, wherein the venous thrombus size lowering therapy is a plasminogen activator inhibitor 1 (PAI-1) inhibitor. Disclosed are methods of diagnosing and VTE, the method comprising diagnosing the subject as being at greater risk of developing VTE; and administering a venous thrombus size lowering therapy to the subject, wherein the venous thrombus size lowering therapy is a PAI-1 inhibitor. Disclosed are methods of determining a PRS for developing VTE in a subject comprising identifying the presence of one or more of the 297 SNPs identified in FIG. 19 are present in a biological sample from the subject; and calculating the PRS by summing the weighted risk score associated with each SNP identified.

Abstract: The present disclosure relates to a method of determining a risk of developing breast cancer in a subject, the method comprising identifying whether at least 95 single nucleotide polymorphisms (SNPs) from Table A is present in a biological sample from the subject, wherein the presence of a risk allele of a SNP from Table A indicates that the subject has an increased risk of breast cancer, and wherein the presence of an alternative allele indicates that the subject has a decreased risk of breast cancer.

Abstract: The present disclosure relates to a method of determining a risk of developing atrial fibrillation in a subject, the method comprising identifying whether at least 95 single nucleotide polymorphisms (SNPs) from Table A is present in a biological sample from the subject, wherein the presence of a risk allele of a SNP from Table A indicates that the subject has an increased risk of atrial fibrillation, and wherein the presence of an alternative allele indicates that the subject has a decreased risk of atrial fibrillation.

Abstract: The present disclosure relates to a method of determining a risk of developing inflammatory bowel disease in a subject, the method comprising identifying whether at least 50 single nucleotide polymorphisms (SNPs) from Table A is present in a biological sample from the subject, wherein the presence of a risk allele of a SNP from Table A indicates that the subject has an increased risk of inflammatory bowel disease, and wherein the presence of an alternative allele indicates that the subject has a decreased risk of inflammatory bowel disease.

Abstract: The present disclosure relates to a method of determining a risk of developing diabetes in a subject, the method comprising identifying whether at least 50 single nucleotide polymorphisms (SNPs) from Table A is present in a biological sample from the subject, wherein the presence of a risk allele of a SNP from Table A indicates that the subject has an increased risk of diabetes, and wherein the presence of an alternative allele indicates that the subject has a decreased risk of diabetes.

Abstract: The present disclosure relates to a method of determining a risk of developing coronary artery disease in a subject, the method comprising identifying whether at least 95 single nucleotide polymorphisms (SNPs) from Table D is present in a biological sample from the subject, wherein the presence of a risk allele of a SNP from Table D indicates that the subject has an increased risk of coronary artery disease, and wherein the presence of an alternative allele indicates that the subject has a decreased risk of coronary artery disease.