Patents by Inventor Derek L. Greenfield

Derek L. Greenfield has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods And Compositions For Improved Production Of Fatty Acids And Derivatives Thereof
    Publication number: 20210371889
    Abstract: The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, and engineered host cells for producing fatty acids and derivates of fatty acids such as acyl-CoA, terminal olefins, fatty aldehydes, fatty alcohols, alkanes, alkenes, wax esters, ketones and internal olefins through altered expression of the transcription factor, fadR.
    Type: Application
    Filed: June 17, 2021
    Publication date: December 2, 2021
    Inventors: Derek L. GREENFIELD, Louis G. HOM, Fernando A. SANCHEZ-RIERA, Zhihao HU, Vikranth ARLAGADDA, Eli S. GROBAN, Scott A. FRYKMAN
  • Production Of Fatty Acid Derivatives
    Publication number: 20210348173
    Abstract: The disclosure relates to recombinant host cells including strain modifications effective to improve titer, yield and/or productivity of fatty acid derivatives. The disclosure further relates to cell cultures including the recombinant host cells for the fermentative production of fatty acid derivatives and compositions thereof.
    Type: Application
    Filed: June 1, 2021
    Publication date: November 11, 2021
    Inventors: Derek L. GREENFIELD, Andreas W. SCHIRMER, Elizabeth J. CLARKE, Eli S. GROBAN, Bernardo M. DA COSTA, Zhihao HU, Kevin HOLDEN, Noah HELMAN
  • Acetyl-CoA carboxylase variants
    Patent number: 11142756
    Abstract: The disclosure relates to acetyl-CoA carboxylase (ACC) variants and host cells expressing them for the production of malonyl-CoA derived compounds including fatty acid derivatives. Further contemplated are methods of producing increased amounts of malonyl-CoA derived compounds and related cell cultures.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: October 12, 2021
    Assignee: Genomatica, Inc.
    Inventors: Derek L. Greenfield, Donald E. Trimbur, Andreas W. Schirmer, Cindy Chang, Behnaz Behrouzian, Jessica Winger
  • Methods and compositions for improved production of fatty acids and derivatives thereof
    Patent number: 11066682
    Abstract: The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, and engineered host cells for producing fatty acids and derivates of fatty acids such as acyl-CoA, terminal olefins, fatty aldehydes, fatty alcohols, alkanes, alkenes, wax esters, ketones and internal olefins through altered expression of the transcription factor, fadR.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: July 20, 2021
    Assignee: Genomatica, Inc.
    Inventors: Derek L. Greenfield, Louis G. Hom, Fernando A. Sanchez-Riera, Zhihao Hu, Vikranth Arlagadda, Eli S. Groban, Scott A. Frykman
  • Production of fatty acid derivatives
    Patent number: 11060099
    Abstract: The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, recombinant host cells and recombinant host cell cultures engineered to produce fatty acid derivative compositions comprising fatty acids, fatty alcohols, fatty aldehydes, fatty esters, alkanes, terminal olefins, internal olefins or ketones. The fatty acid derivative composition is produced extracellularly with a higher titer, yield or productivity than the corresponding wild type or non-engineered host cell.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: July 13, 2021
    Assignee: Genomatica, Inc.
    Inventors: Derek L. Greenfield, Andreas W. Schirmer, Elizabeth J. Clarke, Eli S. Groban, Bernardo M. Da Costa, Zhihao Hu, Kevin Holden, Noah Helman
  • Car enzymes and improved production of fatty alcohols
    Patent number: 11034937
    Abstract: The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: June 15, 2021
    Assignee: Genomatica, Inc.
    Inventors: Derek L. Greenfield, Elizabeth J. Clarke, Eli S. Groban, Vikranth Arlagadda, Sungwon Lee, Xuezhi Li, Zhihao Hu, Baolong Zhu
  • ACETYL-COA CARBOXYLASE VARIANTS
    Publication number: 20210009983
    Abstract: The disclosure relates to acetyl-CoA carboxylase (ACC) variants and host cells expressing them for the production of malonyl-CoA derived compounds including fatty acid derivatives. Further contemplated are methods of producing increased amounts of malonyl-CoA derived compounds and related cell cultures.
    Type: Application
    Filed: February 26, 2020
    Publication date: January 14, 2021
    Applicant: Genomatica, Inc.
    Inventors: Derek L. GREENFIELD, Donald E. TRIMBUR, Andreas W. SCHIRMER, Cindy CHANG, Behnaz BEHROUZIAN, Jessica WINGER
  • NOVEL CAR ENZYMES AND IMPROVED PRODUCTION OF FATTY ALCOHOLS
    Publication number: 20200109374
    Abstract: The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.
    Type: Application
    Filed: May 16, 2019
    Publication date: April 9, 2020
    Inventors: Derek L. Greenfield, Elizabeth J. Clarke, Eli S. Groban, Vikranth Arlagadda, Sungwon Lee, Xuezhi Li, Zhihao Hu, Baolong Zhu
  • Acetyl-CoA carboxylase variants
    Patent number: 10604750
    Abstract: The disclosure relates to acetyl-CoA carboxylase (ACC) variants and host cells expressing them for the production of malonyl-CoA derived compounds including fatty acid derivatives. Further contemplated are methods of producing increased amounts of malonyl-CoA derived compounds and related cell cultures.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: March 31, 2020
    Assignee: GENOMATICA, INC.
    Inventors: Derek L. Greenfield, Donald E. Trimbur, Andreas W. Schirmer, Cindy Chang, Behnaz Behrouzian, Jessica Winger
  • Car enzymes and improved production of fatty alcohols
    Patent number: 10301603
    Abstract: The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: May 28, 2019
    Assignee: Reg Life Sciences, LLC
    Inventors: Derek L. Greenfield, Elizabeth J. Clarke, Eli S. Groban, Vikranth Arlagadda, Sungwon Lee, Xuezhi Li, Zhihao Hu, Baolong Zhu
  • NOVEL CAR ENZYMES AND IMPROVED PRODUCTION OF FATTY ALCOHOLS
    Publication number: 20180135028
    Abstract: The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.
    Type: Application
    Filed: September 5, 2017
    Publication date: May 17, 2018
    Inventors: Derek L. GREENFIELD, Elizabeth J. CLARKE, Eli S. GROBAN, Vikranth Arlagadda, Sungwon LEE, Xuezhi LI, Zhihao Hu, Baolong ZHU
  • PRODUCTION OF FATTY ACID DERIVATIVES
    Publication number: 20180010137
    Abstract: The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, recombinant host cells and recombinant host cell cultures engineered to produce fatty acid derivative compositions comprising fatty acids, fatty alcohols, fatty aldehydes, fatty esters, alkanes, terminal olefins, internal olefins or ketones. The fatty acid derivative composition is produced extracellularly with a higher titer, yield or productivity than the corresponding wild type or non-engineered host cell.
    Type: Application
    Filed: July 14, 2017
    Publication date: January 11, 2018
    Inventors: Derek L. GREENFIELD, Andreas W. Schirmer, Elizabeth J. CLARKE, Eli S. GROBAN, Bernardo M. Da Costa, Zhihao Hu, Kevin Holden, Noah Helman
  • Car enzymes and improved production of fatty alcohols
    Patent number: 9758769
    Abstract: The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: September 12, 2017
    Assignee: REG LIFE SCIENCES, LLC
    Inventors: Derek L. Greenfield, Elizabeth Clarke, Eli Groban, Vikranth Arlagadda, Sungwon Lee, Xuezhi Li, Zhihao Hu, Baolong Zhu
  • METHODS AND COMPOSITIONS FOR ENHANCED PRODUCTION OF FATTY ALDEHYDES AND FATTY ALCOHOLS
    Publication number: 20170096688
    Abstract: The invention relates to the use of EntD polypeptides, polynucleotides encoding the same, and homologues thereof to enhance the production of fatty aldehydes and fatty alcohols in a host cell.
    Type: Application
    Filed: May 16, 2016
    Publication date: April 6, 2017
    Inventors: Zhihao HU, Derek L. GREENFIELD, Vikranth Arlagadda
  • NOVEL CAR ENZYMES AND IMPROVED PRODUCTION OF FATTY ALCOHOLS
    Publication number: 20160326499
    Abstract: The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.
    Type: Application
    Filed: May 13, 2016
    Publication date: November 10, 2016
    Applicant: Reg Life Sciences, LLC
    Inventors: Derek L. GREENFIELD, Elizabeth CLARKE, Eli GROBAN, Vikranth Arlagadda, Sungwon LEE, Xuezhi LI, Zhihao Hu, Baolong ZHU
  • IMPROVED ACETYL-COA CARBOXYLASE VARIANTS
    Publication number: 20160230164
    Abstract: The disclosure relates to acetyl-CoA carboxylase (ACC) variants and host cells expressing them for the production of malonyl-CoA derived compounds including fatty acid derivatives. Further contemplated are methods of producing increased amounts of malonyl-CoA derived compounds and related cell cultures.
    Type: Application
    Filed: September 12, 2014
    Publication date: August 11, 2016
    Applicant: REG Life Sciences, LLC
    Inventors: Derek L. GREENFIELD, Donald E. TRIMBUR, Andreas W. SCHIRMER, Cindy CHANG, Behnaz BEHROUZIAN, Jessica WINGER
  • Car enzymes and improved production of fatty alcohols
    Patent number: 9340801
    Abstract: The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.
    Type: Grant
    Filed: April 2, 2013
    Date of Patent: May 17, 2016
    Assignee: REG LIFE SCIENCES, LLC
    Inventors: Derek L. Greenfield, Elizabeth J. Clarke, Eli S. Groban, Vikranth Arlagadda, Sungwon Lee, Xuezhi Li, Zhihao Hu, Baolong Zhu
  • METHODS AND COMPOSITIONS FOR ENHANCED PRODUCTION OF FATTY ALDEHYDES AND FATTY ALCOHOLS
    Publication number: 20160032328
    Abstract: The invention relates to the use of EntD polypeptides, polynucleotides encoding the same, and homologues thereof to enhance the production of fatty aldehydes and fatty alcohols in a host cell.
    Type: Application
    Filed: February 13, 2014
    Publication date: February 4, 2016
    Applicant: REG Life Sciences, LLC
    Inventors: Zhihao HU, Derek L. GREENFIELD, Vikranth ARLAGADDA
  • PRODUCTION OF FATTY ACIDS AND DERIVATIVES THEREOF HAVING IMPROVED ALIPHATIC CHAIN LENGTH AND SATURATION CHARACTERISTICS
    Publication number: 20150125933
    Abstract: The invention relates to compositions, including polynucleotide sequences, amino acid sequences, recombinant microorganisms, and recombinant microorganism cultures that produce compositions of fatty acids and derivatives having target aliphatic chain lengths and/or preferred percent saturation. Further, the invention relates to methods of making and using the compositions. The compositions and methods provide for high titers, high yields, and high productivities of fatty acids and derivatives thereof.
    Type: Application
    Filed: August 17, 2012
    Publication date: May 7, 2015
    Applicant: LS9, INC.
    Inventors: Eli S. Groban, Vikranth Arlagadda, Scott A. Frykman, Derek L. Greenfield, Zhihao Hu
  • NOVEL CAR ENZYMES AND IMPROVED PRODUCTION OF FATTY ALCOHOLS
    Publication number: 20150064757
    Abstract: The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.
    Type: Application
    Filed: April 2, 2013
    Publication date: March 5, 2015
    Applicant: REG Life Sciences, LLC
    Inventors: Derek L. Greenfield, Elizabeth J. Clarke, Eli S. Groban, Vikranth Arlagadda, Sungwon Lee, Xuezhi Li, Zhihao Hu