Patents by Inventor Derek Law

Derek Law has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11819503
    Abstract: The invention relates to the therapeutic use of olorofim, 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide in the prevention and treatment of a fungal infection caused by a Coccidioides species.
    Type: Grant
    Filed: April 22, 2020
    Date of Patent: November 21, 2023
    Assignees: F2G Ltd
    Inventors: Derek Law, John H. Rex, Michael Birch, Nathan P. Wiederhold, Thomas F. Patterson
  • Patent number: 11065228
    Abstract: The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide or a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: July 20, 2021
    Assignee: F2G Limited
    Inventors: Graham Edward Morris Sibley, Derek Law, Jason David Oliver, Michael Birch
  • Publication number: 20210186967
    Abstract: A pharmaceutical composition suitable for oral administration comprising particles of 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide is provided. Also provided is a pharmaceutical composition suitable for parenteral administration wherein the composition comprises 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide. The compositions are useful in the treatment of fungal infection in a subject in need thereof.
    Type: Application
    Filed: March 1, 2021
    Publication date: June 24, 2021
    Inventors: Derek LAW, Graham Edward Morris SIBLEY
  • Patent number: 10973821
    Abstract: A pharmaceutical composition suitable for oral administration comprising particles of 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2- oxoacetamideis provided. Also provided is a pharmaceutical composition suitable for parenteral administration wherein the composition comprises 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide. The compositions are useful in the treatment of fungal infection in a subject in need thereof.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: April 13, 2021
    Assignee: F2G LIMITED
    Inventors: Derek Law, Graham Edward Morris Sibley
  • Publication number: 20200338072
    Abstract: The invention relates to the therapeutic use of olorofim, 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide in the prevention and treatment of a fungal infection caused by a Coccidioides species.
    Type: Application
    Filed: April 22, 2020
    Publication date: October 29, 2020
    Inventors: Derek LAW, John H. REX, Michael BIRCH
  • Publication number: 20200179340
    Abstract: The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide or a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases.
    Type: Application
    Filed: February 10, 2020
    Publication date: June 11, 2020
    Inventors: Graham Edward Morris SIBLEY, Derek LAW, Jason David OLIVER, Michael BIRCH
  • Patent number: 10596150
    Abstract: The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide or a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: March 24, 2020
    Assignee: F2G LIMITED
    Inventors: Graham Edward Morris Sibley, Derek Law, Jason David Oliver, Michael Birch
  • Publication number: 20190353344
    Abstract: A once-through steam generator for use at an oilfield operation site includes: a control module having an enclosure including controls for operating the steam generator, a radiant module including a radiant chamber, and a convective module including an economizer heat exchanger. The enclosure is erected prior to transportation to the operation site.
    Type: Application
    Filed: May 15, 2018
    Publication date: November 21, 2019
    Inventors: Derek Law, Mitchell Galvin, Jonathan J. Wiersma
  • Publication number: 20190328737
    Abstract: A pharmaceutical composition suitable for oral administration comprising particles of 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide is provided. Also provided is a pharmaceutical composition suitable for parenteral administration wherein the composition comprises 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide. The compositions are useful in the treatment of fungal infection in a subject in need thereof.
    Type: Application
    Filed: May 25, 2017
    Publication date: October 31, 2019
    Applicants: F2G LIMITED, F2G LIMITED
    Inventors: Derek LAW, Graham Edward Morris SIBLEY
  • Patent number: 10448753
    Abstract: An insulated glass unit (20) is described and includes at least first and second glass pane (22, 32) and an optional third glass pane (42). Any one or more of the glass panes (22, 32, 42) may have a thickness of less than or equal to about 0.7 mm. In some instances, any one or more of the glass panes may form part of an electronic display. The insulated glass unit (20) has a lower mass and an improved thermal performance compared to a conventional triple pane insulated glass unit, and is particularly suited for use in a display cooler door.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: October 22, 2019
    Assignee: CORNING INCORPORATED
    Inventors: Kirk Wegner Christiansen, Dan Owewn Harris, Tak Lap Derek Law, Daniel Louis Gabriel Ricoult, Mark J Soulliere
  • Publication number: 20190314333
    Abstract: The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide or a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases.
    Type: Application
    Filed: December 17, 2018
    Publication date: October 17, 2019
    Inventors: Graham Edward Morris SIBLEY, Derek LAW, Jason David OLIVER, Michael BIRCH
  • Patent number: 10201524
    Abstract: The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide or a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: February 12, 2019
    Assignee: F2G LIMITED
    Inventors: Graham Edward Morris Sibley, Derek Law, Jason David Oliver, Michael Birch
  • Publication number: 20190034506
    Abstract: Geolocation data is analyzed for geolocation patterns relevant to personal information of a user that operates a device for which the geolocation data is associated with. The geolocation-determined personal information and other personal information are automatically synchronized and shared between the device and services of the user.
    Type: Application
    Filed: July 31, 2017
    Publication date: January 31, 2019
    Inventors: Daniel Maxey Williford, Andrew Derek Law, Gary Stuart Mason
  • Publication number: 20170340607
    Abstract: The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamideor a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases.
    Type: Application
    Filed: November 20, 2015
    Publication date: November 30, 2017
    Inventors: Graham Edward Morris SIBLEY, Derek LAW, Jason David OLIVER, Michael BIRCH
  • Publication number: 20170119176
    Abstract: An insulated glass unit (20) is described and includes at least first and second glass pane (22, 32) and an optional third glass pane (42). Any one or more of the glass panes (22, 32, 42) may have a thickness of less than or equal to about 0.7 mm. In some instances, any one or more of the glass panes may form part of an electronic display. The insulated glass unit (20) has a lower mass and an improved thermal performance compared to a conventional triple pane insulated glass unit, and is particularly suited for use in a display cooler door.
    Type: Application
    Filed: June 26, 2015
    Publication date: May 4, 2017
    Inventors: Kirk Wegner Christiansen, Dan Owewn Harris, Tak Lap Derek Law, Daniel Louis Gabriel Ricoult, Mark J Soulliere
  • Patent number: 9452168
    Abstract: The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof; wherein: R1, R2, R3, R4, R5, R6, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: September 27, 2016
    Assignee: F2G LTD
    Inventors: Graham Edward Morris Sibley, Robert Downham, Lloyd James Payne, Derek Law, Jason David Oliver, Michael Birch, Gareth Morse Davies
  • Publication number: 20150238500
    Abstract: The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof; wherein: R1, R2, R3, R4, R5, R6, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.
    Type: Application
    Filed: February 18, 2015
    Publication date: August 27, 2015
    Inventors: Graham Edward Morris SIBLEY, Robert DOWNHAM, Lloyd James PAYNE, Derek LAW, Jason David OLIVER, Michael BIRCH, Gareth Morse DAVIES
  • Patent number: 8993574
    Abstract: The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof; wherein: R1, R2, R3, R4, R5, R6, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.
    Type: Grant
    Filed: April 23, 2009
    Date of Patent: March 31, 2015
    Assignee: F2G Ltd
    Inventors: Graham Edward Morris Sibley, Robert Downham, Lloyd James Payne, Derek Law, Jason David Oliver, Mike Birch, Gareth Morse Davies, Patricia Suling Davies
  • Publication number: 20110183969
    Abstract: The invention provides pharmaceutical combinations comprising a combination of an antifungal indolizine compound of formula (I) or a pharmaceutically acceptable salt thereof and a second antifungal agent: wherein: R1, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. The invention also provides pharmaceutical compositions comprising an antifungal indolizine compound of formula (I) or a pharmaceutically acceptable salt thereof, a second antifungal agent and a pharmaceutically acceptable diluent or carrier. The combinations and compositions are useful in the prevention or treatment of a fungal disease. A combination of an indolizine compound of formula (I) or agriculturally acceptable salts thereof and a second antifungal agent may also be used as an agricultural fungicide.
    Type: Application
    Filed: May 29, 2009
    Publication date: July 28, 2011
    Inventors: Michael Birch, Graham Edward Morris Sibley, Derek Law, Jason David Oliver
  • Publication number: 20110152285
    Abstract: The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof; wherein: R1, R2, R3, R4, R5, R6, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.
    Type: Application
    Filed: April 23, 2009
    Publication date: June 23, 2011
    Inventors: Graham Edward Morris Sibley, Robert Downham, Lloyd James Payne, Derek Law, Jason David Oliver, Mike Birch, Gareth Morse Davies, Patricia Suling Davies