Patents by Inventor Derek Law
Derek Law has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11819503Abstract: The invention relates to the therapeutic use of olorofim, 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide in the prevention and treatment of a fungal infection caused by a Coccidioides species.Type: GrantFiled: April 22, 2020Date of Patent: November 21, 2023Assignees: F2G LtdInventors: Derek Law, John H. Rex, Michael Birch, Nathan P. Wiederhold, Thomas F. Patterson
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Patent number: 11065228Abstract: The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide or a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases.Type: GrantFiled: February 10, 2020Date of Patent: July 20, 2021Assignee: F2G LimitedInventors: Graham Edward Morris Sibley, Derek Law, Jason David Oliver, Michael Birch
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Publication number: 20210186967Abstract: A pharmaceutical composition suitable for oral administration comprising particles of 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide is provided. Also provided is a pharmaceutical composition suitable for parenteral administration wherein the composition comprises 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide. The compositions are useful in the treatment of fungal infection in a subject in need thereof.Type: ApplicationFiled: March 1, 2021Publication date: June 24, 2021Inventors: Derek LAW, Graham Edward Morris SIBLEY
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Patent number: 10973821Abstract: A pharmaceutical composition suitable for oral administration comprising particles of 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2- oxoacetamideis provided. Also provided is a pharmaceutical composition suitable for parenteral administration wherein the composition comprises 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide. The compositions are useful in the treatment of fungal infection in a subject in need thereof.Type: GrantFiled: May 25, 2017Date of Patent: April 13, 2021Assignee: F2G LIMITEDInventors: Derek Law, Graham Edward Morris Sibley
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Publication number: 20200338072Abstract: The invention relates to the therapeutic use of olorofim, 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide in the prevention and treatment of a fungal infection caused by a Coccidioides species.Type: ApplicationFiled: April 22, 2020Publication date: October 29, 2020Inventors: Derek LAW, John H. REX, Michael BIRCH
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Publication number: 20200179340Abstract: The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide or a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases.Type: ApplicationFiled: February 10, 2020Publication date: June 11, 2020Inventors: Graham Edward Morris SIBLEY, Derek LAW, Jason David OLIVER, Michael BIRCH
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Patent number: 10596150Abstract: The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide or a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases.Type: GrantFiled: December 17, 2018Date of Patent: March 24, 2020Assignee: F2G LIMITEDInventors: Graham Edward Morris Sibley, Derek Law, Jason David Oliver, Michael Birch
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Publication number: 20190353344Abstract: A once-through steam generator for use at an oilfield operation site includes: a control module having an enclosure including controls for operating the steam generator, a radiant module including a radiant chamber, and a convective module including an economizer heat exchanger. The enclosure is erected prior to transportation to the operation site.Type: ApplicationFiled: May 15, 2018Publication date: November 21, 2019Inventors: Derek Law, Mitchell Galvin, Jonathan J. Wiersma
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Publication number: 20190328737Abstract: A pharmaceutical composition suitable for oral administration comprising particles of 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide is provided. Also provided is a pharmaceutical composition suitable for parenteral administration wherein the composition comprises 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide. The compositions are useful in the treatment of fungal infection in a subject in need thereof.Type: ApplicationFiled: May 25, 2017Publication date: October 31, 2019Applicants: F2G LIMITED, F2G LIMITEDInventors: Derek LAW, Graham Edward Morris SIBLEY
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Patent number: 10448753Abstract: An insulated glass unit (20) is described and includes at least first and second glass pane (22, 32) and an optional third glass pane (42). Any one or more of the glass panes (22, 32, 42) may have a thickness of less than or equal to about 0.7 mm. In some instances, any one or more of the glass panes may form part of an electronic display. The insulated glass unit (20) has a lower mass and an improved thermal performance compared to a conventional triple pane insulated glass unit, and is particularly suited for use in a display cooler door.Type: GrantFiled: June 26, 2015Date of Patent: October 22, 2019Assignee: CORNING INCORPORATEDInventors: Kirk Wegner Christiansen, Dan Owewn Harris, Tak Lap Derek Law, Daniel Louis Gabriel Ricoult, Mark J Soulliere
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Publication number: 20190314333Abstract: The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide or a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases.Type: ApplicationFiled: December 17, 2018Publication date: October 17, 2019Inventors: Graham Edward Morris SIBLEY, Derek LAW, Jason David OLIVER, Michael BIRCH
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Patent number: 10201524Abstract: The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide or a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases.Type: GrantFiled: November 20, 2015Date of Patent: February 12, 2019Assignee: F2G LIMITEDInventors: Graham Edward Morris Sibley, Derek Law, Jason David Oliver, Michael Birch
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Publication number: 20190034506Abstract: Geolocation data is analyzed for geolocation patterns relevant to personal information of a user that operates a device for which the geolocation data is associated with. The geolocation-determined personal information and other personal information are automatically synchronized and shared between the device and services of the user.Type: ApplicationFiled: July 31, 2017Publication date: January 31, 2019Inventors: Daniel Maxey Williford, Andrew Derek Law, Gary Stuart Mason
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Publication number: 20170340607Abstract: The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamideor a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases.Type: ApplicationFiled: November 20, 2015Publication date: November 30, 2017Inventors: Graham Edward Morris SIBLEY, Derek LAW, Jason David OLIVER, Michael BIRCH
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Publication number: 20170119176Abstract: An insulated glass unit (20) is described and includes at least first and second glass pane (22, 32) and an optional third glass pane (42). Any one or more of the glass panes (22, 32, 42) may have a thickness of less than or equal to about 0.7 mm. In some instances, any one or more of the glass panes may form part of an electronic display. The insulated glass unit (20) has a lower mass and an improved thermal performance compared to a conventional triple pane insulated glass unit, and is particularly suited for use in a display cooler door.Type: ApplicationFiled: June 26, 2015Publication date: May 4, 2017Inventors: Kirk Wegner Christiansen, Dan Owewn Harris, Tak Lap Derek Law, Daniel Louis Gabriel Ricoult, Mark J Soulliere
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Patent number: 9452168Abstract: The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof; wherein: R1, R2, R3, R4, R5, R6, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.Type: GrantFiled: February 18, 2015Date of Patent: September 27, 2016Assignee: F2G LTDInventors: Graham Edward Morris Sibley, Robert Downham, Lloyd James Payne, Derek Law, Jason David Oliver, Michael Birch, Gareth Morse Davies
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Publication number: 20150238500Abstract: The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof; wherein: R1, R2, R3, R4, R5, R6, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.Type: ApplicationFiled: February 18, 2015Publication date: August 27, 2015Inventors: Graham Edward Morris SIBLEY, Robert DOWNHAM, Lloyd James PAYNE, Derek LAW, Jason David OLIVER, Michael BIRCH, Gareth Morse DAVIES
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Patent number: 8993574Abstract: The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof; wherein: R1, R2, R3, R4, R5, R6, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.Type: GrantFiled: April 23, 2009Date of Patent: March 31, 2015Assignee: F2G LtdInventors: Graham Edward Morris Sibley, Robert Downham, Lloyd James Payne, Derek Law, Jason David Oliver, Mike Birch, Gareth Morse Davies, Patricia Suling Davies
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Publication number: 20110183969Abstract: The invention provides pharmaceutical combinations comprising a combination of an antifungal indolizine compound of formula (I) or a pharmaceutically acceptable salt thereof and a second antifungal agent: wherein: R1, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. The invention also provides pharmaceutical compositions comprising an antifungal indolizine compound of formula (I) or a pharmaceutically acceptable salt thereof, a second antifungal agent and a pharmaceutically acceptable diluent or carrier. The combinations and compositions are useful in the prevention or treatment of a fungal disease. A combination of an indolizine compound of formula (I) or agriculturally acceptable salts thereof and a second antifungal agent may also be used as an agricultural fungicide.Type: ApplicationFiled: May 29, 2009Publication date: July 28, 2011Inventors: Michael Birch, Graham Edward Morris Sibley, Derek Law, Jason David Oliver
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Publication number: 20110152285Abstract: The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof; wherein: R1, R2, R3, R4, R5, R6, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.Type: ApplicationFiled: April 23, 2009Publication date: June 23, 2011Inventors: Graham Edward Morris Sibley, Robert Downham, Lloyd James Payne, Derek Law, Jason David Oliver, Mike Birch, Gareth Morse Davies, Patricia Suling Davies