Abstract: Provided are modified arginine deiminase (ADI) proteins, including ADI proteins that comprise one or more substitutions which increase expression in bacteria as insoluble and refoldable inclusion bodies. Also provided are methods of producing the modified ADI proteins, compositions comprising the ADI proteins, and related methods of treating arginine-dependent and related diseases such as cancer.

Abstract: Systems, methods, and devices for analyzing small volumes of fluidic samples, as a non-limiting example, less than twenty microliters are provided. The devices are configured to make a first sample reading, for example, measure an energy property of the fluid sample, for example, osmolality, make a second sample reading, for example, detecting the presence or concentration of one or more analytes in the fluid sample, or make both the first sample reading and the second sample reading, for example, measuring the energy property of the fluid sample as well as detecting the presence or concentration of one or more analytes in the fluid sample.

Abstract: Aspects of the present disclosure relate to methods and compositions related to the preparation of immune cells, including engineered T cells comprising at least one exogenous ?? T cell receptor, for example one that is selected to target a specific disease or pathogen (e.g., cancer or COVID-19). The T cells may be produced from human hematopoietic stem/progenitor cells and are suitable for allogeneic cellular therapy because they do not induce graft-versus-host disease (GvHD) and resist host immune allorejection. Consequently, such cells are suitable for off-the-shelf use in clinical therapy.

Abstract: Systems, methods, and devices for analyzing small volumes of fluidic samples, as a non-limiting example, less than twenty microliters are provided. The devices are configured to make a first sample reading, for example, measure an energy property of the fluid sample, for example, osmolality, make a second sample reading, for example, detecting the presence or concentration of one or more analytes in the fluid sample, or make both the first sample reading and the second sample reading, for example, measuring the energy property of the fluid sample as well as detecting the presence or concentration of one or more analytes in the fluid sample.

Abstract: A serial system and method for blowing antifuses are disclosed. One embodiment of antifuse system includes a plurality of latch devices connected in series from input to output. The system also includes a plurality of antifuses. The antifuses are configured to receive an output signal from a corresponding one of the latch devices. The plurality of latch devices includes a plurality of D flip-flops connected in series. Each of the D flip-flops is configured to receive an output signal from an immediately previous D flip-flop in the serial data flow and to provide an output signal to an immediately subsequent D flip-flop in the flow. In addition, the serial system provides self-detective antifuses, thus creating reliable electrical paths while saving antifuse blowing current resources and time.

Abstract: A decision feedback-based communication system comprising a unit for computing an estimated Error Propagation Probability (EPP) for a plurality of received signals, and a unit for receiving the EPP estimation and improving detected signal quality based thereon. The system can be a coded system or an uncoded system.

Abstract: A serial system and method for blowing antifuses are disclosed. One embodiment of antifuse system includes a plurality of latch devices connected in series from input to output. The system also includes a plurality of antifuses. The antifuses are configured to receive an output signal from a corresponding one of the latch devices. The plurality of latch devices includes a plurality of D flip-flops connected in series. Each of the D flip-flops is configured to receive an output signal from an immediately previous D flip-flop in the serial data flow and to provide an output signal to an immediately subsequent D flip-flop in the flow. In addition, the serial system provides self-detective antifuses, thus creating reliable electrical paths while saving antifuse blowing current resources and time.