Patents by Inventor Derek Mark Erion

Derek Mark Erion has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR DISRUPTING NRF2-KEAP1 PROTEIN INTERACTION BY ADAR MEDIATED RNA EDITING
    Publication number: 20250352667
    Abstract: The present invention relates to methods and compositions for disrupting interaction of an NRF2 protein and a KEAP1 protein. The methods include contacting at least one polynucleotide selected from the group consisting of a polynucleotide encoding the NRF2 protein and a polynucleotide encoding the KEAP1 protein with a guide oligonucleotide that effects one or more (e.g., at least two) adenosine deaminase acting on RNA (ADAR)-mediated adenosine to inosine alterations in said at least one polynucleotide, wherein the adenosine to inosine alterations generate a mutant amino acid, thereby disrupting interaction of the NRF2 protein and the KEAP1 protein.
    Type: Application
    Filed: October 20, 2022
    Publication date: November 20, 2025
    Inventors: Stephen V. Su, Mallikarjuna Reddy Putta, Todd William Chappell, Matthew Blair Jarpe, Madhav Narashimha Devalaraja, Kevin Lai, Kurt Patterson Herzog, Derek Mark Erion, Jesse Lee Dabney, Camille M. Konopnicki