Abstract: The invention relates to an oncofetal glycoprotein, referred to as MQ-1, nucleic acid sequences coding for the protein, and antibodies which bind specifically to the protein. Also described is a hybridoma capable of producing monoclonal antibodies which bind specifically to the protein of the invention. Methods, and kits, for diagnosing and treating cancer using the antibodies of the invention are also described. Anti-sense polynucleotides are also described, as are methods for inducing apoptosis in cells which express MQ-1.

Abstract: A sprinkler system control valve has a "wet" valve which is maintained seated against a mains water inlet by water pressure applied to a piston of larger effective area than the wet valve. The sprinkler system downstream of the wet valve is charged with air at a relatively low pressure, this air pressure also being supplied to an actuator chamber so as to maintain a deadweight in a lifted position. Upon operation of a sprinkler head the air pressure in the system drops rapidly, causing the deadweight to descend, operating a trip valve through a self-locking cam. Once operated, the trip valve vents the pressure on the piston to an exhaust port allowing the wet valve to open, and at the same time cutting off the actuator chamber from the sprinkler system by the entry of a sealing O-ring into an internal bore in the wet valve housing.