Abstract: Irritable Bowel Syndrome (IBS) is a multifactorial disorder characterized by pain, bloat, and changes in bowel movements, where different bacteria in the gut microbiome potentially influence some or all of the related symptoms. However, IBS is extremely heterogenous, suggesting a need to identify relationships between groups of bacteria in the gut microbiome and specific IBS-related symptoms. RS consumption significantly altered the microbiome while improving several measures of IBS. The use of RS by those needing to reduce the IBS-related symptoms, including those diagnosed with IBS, can be guided by simultaneously measuring changes in select genera in the microbiome.

Abstract: Elucidating the relationship between specific intestinal bacteria, dietary intake, and the health of the host remains a primary goal for gut microbiome research. Prebiotics, substrates that are selectively used by microorganisms to promote the health of the host, present an appealing therapeutic option. We performed correlation analysis to identify relationships between health parameters and populations of gut bacteria in participants from a randomized, placebo-controlled clinical trial testing the effects of a prebiotic digestion resistant potato starch (DRS; MSPrebiotic®). This study focused on the abundance of Parasutterella (phylum Proteobacteria), which tended to increase in the gut microbiome of individuals consuming DRS. Increases in Parasutterella were correlated with reductions in low-density lipoprotein (LDL) levels in participants consuming DRS but not placebo.

Abstract: Individuals consuming a prebiotic and who displayed improvements in blood glucose and/or insulin levels also displayed a decrease in the levels of the non-butyrate-producing Firmicutes genus of bacteria Sporacetigenium. Increasing levels of butyrate-producing Firmicutes genera were not consistently correlated with improvements in metabolism in response to prebiotic consumption. In the general population, Sporacetigenium levels are positively correlated with insulin levels.

Abstract: Consumption of resistant potato starch results in changes to the gut microbiome in elderly adults, resulting in a healthier gut microbiome profile. Furthermore, consumption of resistant potato starch stimulates an increase in Bifidobacterium abundance in all individuals and also reduces levels of E. coli and Shigella. Furthermore, consumption of MSPrebiotic® increased the relative ratio of butyrate in the elderly and significantly reduced the use of stool softeners in the elderly.

Abstract: Resistant potato starch is demonstrated to have therapeutic effects on ulcerative colitis through attenuation of diarrhea, repair or reduction of intestinal damage, modulation of local gene expression and treatment of intestinal dysbiosis. Administering resistant potato starch in pigs pre-exposed to colitis improved fecal score although use of resistant potato starch as a preventive measure did not prevent diarrhea associated with induction of colitis and in fact impaired the ability of the resistant potato starch to treat ulcerative colitis.

Abstract: Resistant potato starch is demonstrated to have therapeutic effects on ulcerative colitis through attenuation of diarrhea, repair or reduction of intestinal damage, modulation of local gene expression and treatment of intestinal dysbiosis. Administering resistant potato starch in pigs pre-exposed to colitis improved fecal score although use of resistant potato starch as a preventive measure did not prevent diarrhea associated with induction of colitis and in fact impaired the ability of the resistant potato starch to treat ulcerative colitis.

Abstract: Described herein is the use of resistant potato starch as an effective dietary supplement offering protection against multiple metabolic risk factors that are associated with cardiovascular disease and diabetes, including High Density Lipoprotein levels, blood glucose levels and insulin resistance.

Abstract: Consumption of resistant potato starch results in changes to the gut microbiome in elderly adults, resulting in a healthier gut microbiome profile. Furthermore, consumption of resistant potato starch stimulates an increase in Bifidobacterium abundance in all individuals and also reduces levels of E. coli and Shigella. Furthermore, consumption of MSPrebiotic® increased the relative ratio of butyrate in the elderly and significantly reduced the use of stool softeners in the elderly.

Abstract: Low levels of resistant potato starch, for example, 0.5-1.0% of total diet, have a beneficial effect on post-weaning diarrhea, infectious diarrhea and gastrointestinal stresses associated with weaning. Also described are capsules and tablets of resistant potato starch, and methods for making said capsules and tablets.

Abstract: Described herein is the use of resistant potato starch as an effective dietary supplement offering protection against multiple metabolic risk factors that are associated with cardiovascular disease and diabetes, including High Density Lipoprotein levels, blood glucose levels and insulin resistance.

Abstract: Low levels of resistant potato starch, for example, 0.5-1.0% of total diet, have a beneficial effect on post-weaning diarrhea, infectious diarrhea and gastrointestinal stresses associated with weaning. Also described are capsules and tablets of resistant potato starch, and methods for making said capsules and tablets.