Abstract: A stationary exercise bicycle including a base frame, a seat supporting assembly, a seat assembly being movably mounted on the seat supporting assembly to be guided along a path inclined at a selected angle related to the ground surface. The stationary exercise bicycle further comprises an assistance member attached to the seat assembly for providing an elevation force for a seat position adjustment. The present invention provides a stationary exercise bicycle with a benefit of quick, easy and convenient seat position adjustment, a benefit of grabbing a heart rate grip or touching a control console comfortably, a benefit of reducing abdomen compression of a user, and a benefit of an elevation force for assisting a seat position adjustment.

Abstract: A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.

Abstract: The present invention discloses a compound of formula (I) or a pharmaceutically acceptable salt or prodrug thereof, wherein D, A, m, n, Rx and Ry are defined in the description. The present invention also relates to pharmaceutical compositions of compounds of formula (I), which are useful for treating a disorder selected from the group consisting of chronic inflammatory pain, neuropathic pain, inflammation, neurodegeneration, depression and promoting neuroregeneration. The present invention also relates to a method for treating pain, neuropathic pain, inflammation, chronic inflammatory pain, neurodegeneration, depression and promoting neuroregeneration in a mammal using compounds of formula (II), a pharmaceutically acceptable salt, ester, amide or prodrug thereof, wherein R3 and R4 are defined in the description.

Abstract: The present invention relates to the use of selective P2X7 receptor antagonists of formula I, or a pharmaceutically acceptable salt or prodrug thereof wherein D, R1 and R2 are as defined in claim 1, for the treatment of neuropathic pain, chronic inflammatory pain, inflammation, neurodegeneration and for promoting neuroregeneration,

Abstract: A dual-function exercise device includes lower body exercise device, a frame, and a movable handle assembly. The movable handle assembly includes two independent pulling devices and a rotary shaft journalled on the frame. Each pulling device includes a pulley disposed rotatably on the frame, a pull cord wound on the pulley, a handgrip fastened to an end of the cord and movable to unwind the cord from the pulley, and a biasing unit for biasing the cord to wind around the pulley when the cord is pulled and is subsequently released.

Abstract: A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.

Abstract: Disclosed is an exercise apparatus for use in accurately and automatically tracking number of steps taken by a user both on and off of an exercise machine. The apparatus comprises a step counter such as a pedometer for counting number of steps taken by a user, the step counter continually counting cumulative number of steps taken in a given time period both while the user is on and off of the exercise machine, the step counter having a first communication means for periodically communicating the current cumulative step count to a console of an exercise machine while the user uses the exercise machine; and, the console comprising, a second communication means for receiving the current cumulative number of steps from the step counter while the user uses the exercise machine. The apparatus may further comprise a data processor, a display and a memory means.

Abstract: A dual-function exercise device includes lower body exercise device, a frame, and a movable handle assembly. The movable handle assembly includes two independent pulling devices and a rotary shaft journalled on the frame. Each pulling device includes a pulley disposed rotatably on the frame, a pull cord wound on the pulley, a handgrip fastened to an end of the cord and movable to unwind the cord from the pulley, and a biasing unit for biasing the cord to wind around the pulley when the cord is pulled and is subsequently released.

Abstract: A dual-function treading exerciser includes a treading platform, an upright frame, and a movable handle assembly. The frame includes an upright frame body and two fixed handles connected fixedly to an upper portion of the frame body. The movable handle assembly includes two pulling devices and a rotary shaft journalled on the frame. Each pulling device includes a housing with a receiving chamber, a pulley disposed rotatably in the chamber, a pull cord wound on the pulley, a handgrip fastened to an end of the cord and movable rearwardly to unwind the cord from the pulley, and a biasing unit for biasing the cord to wind around the pulley when the cord is pulled rearwardly and is subsequently released.

Abstract: Method and apparatus for providing generational copy control of a video signal. A digital video signal contains content information, first supplemental information and second supplemental information. The first supplemental information is represented by a watermark pattern, the second by a control pattern. Copying of the content information is only permitted if a predetermined combination of the first and second supplemental information is present. Pseudo-sync pulses are added to a blanking interval of an analog video signal converted from a digital video signal, the pulses representing the second supplemental information.