Abstract: The present invention relates to an isolated antibody, or antigen binding fragment thereof, which specifically binds to an extracellular domain of CD300f, wherein the antibody, or antigen binding fragment thereof, comprises a heavy chain variable region which comprises: (a) an amino acid sequence that is at least 70% identical to the amino acid sequence represented by SEQ ID NO: 1; and/or (b) a complementarity determining region 1 (CDR1) that comprises the amino acid sequence represented by SEQ ID NO: 2, a complementarity determining region 2 (CDR2) that comprises an amino acid sequence that is represented by SEQ ID NO: 3, and/or a complementarity determining region 3 (CDR3) that comprises an amino acid sequence that is represented by SEQ ID NO: 4, compositions comprising the antibody, antigen binding fragment thereof, and uses for therapy.

Abstract: The present disclosure relates to an isolated antibody, or antigen binding fragment thereof, which specifically binds to an extracellular domain of cd300f, wherein the antibody, or antigen binding fragment thereof, comprises a heavy chain variable region which comprises: (a) an amino acid sequence that is at least 70% identical to the amino acid sequence represented by seq id no: 1; and/or (b) a complementarity determining region 1 (cdr1) that comprises the amino acid sequence represented by seq id no: 2, a complementarity determining region 2 (cdr2) that comprises an amino acid sequence that is represented by seq id no: 3, and/or a complementarity determining region 3 (cdr3) that comprises an amino acid sequence that is represented by seq id no: 4, compositions comprising the antibody, antigen binding fragment thereof, and uses for therapy.

Abstract: The present disclosure relates to proteins that bind to CD83 and uses thereof, for example, in therapy, prophylaxis, diagnosis, or prognosis.

Abstract: The present disclosure relates to an isolated antibody, or antigen binding fragment thereof, which specifically binds to an extracellular domain of cd300f, wherein the antibody, or antigen binding fragment thereof, comprises a heavy chain variable region which comprises: (a) an amino acid sequence that is at least 70% identical to the amino acid sequence represented by seq id no: 1; and/or (b) a complementarity determining region 1 (cdr1) that comprises the amino acid sequence represented by seq id no: 2, a complementarity determining region 2 (cdr2) that comprises an amino acid sequence that is represented by seq id no: 3, and/or a complementarity determining region 3 (cdr3) that comprises an amino acid sequence that is represented by seq id no: 4, compositions comprising the antibody, antigen binding fragment thereof, and uses for therapy.

Abstract: The present disclosure relates to proteins that bind to CD83 and uses thereof, for example, in therapy, prophylaxis, diagnosis, or prognosis.

Abstract: The present disclosure relates to proteins that bind to CD83 and uses thereof, for example, in therapy, prophylaxis, diagnosis or prognosis.

Abstract: The present invention relates to a method of treating lymphoma in a subject, and more particularly, for treating Hodgkin lymphoma (HL), and non-Hodgkin lymphoma (NHL). The method comprises administering to the subject an effective amount of a CD83 binding protein. The invention also relates to methods for diagnosing and assessing lymphoma in a subject.

Abstract: The present disclosure relates to proteins that bind to CD83 and uses thereof, for example, in therapy, prophylaxis, diagnosis or prognosis.

Abstract: The present disclosure relates to proteins that bind to CD83 and uses thereof, for example, in therapy, prophylaxis, diagnosis, or prognosis.

Abstract: The present disclosure relates to proteins that bind to CD83 and uses thereof, for example, in therapy, prophylaxis, diagnosis, or prognosis.

Abstract: The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides molecules having structural features characteristic of immunoregulatory signalling (IRS) molecules and which are expressed by cells of haematopoietic lineages such as, in particular, leukocytes. The molecules of the present invention find broad application inter alia as diagnostic markers for cells, targets for cell therapy and as validated drug targets in order to modulate the immune response and to treat, prevent and diagnose a range of diseases conditions including cancer, genetic disease, inflammatory conditions and conditions associated with aberrant haematopoietic cell function or activity. The present invention extends to binding partners of the instant molecules such as, for example, antibodies, ligands, adaptor and other signalling associated molecules, agonists and antagonists and to methods of screening for same.

Abstract: The present invention relates generally to a novel lectin and to derivatives, homologues, analogues, chemical equivalents and mimetics thereof and, more particularly, to a novel type I C-type lectin, herein referred to as “DCL-1”. In particular, the present invention relates to the use of DCL-1 in therapeutic, prophylactic and diagnostic applications.

Abstract: The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides molecules having structural features characteristic of immunoregulatory signalling (IRS) molecules and which are expressed by cells of haematopoietic lineages such as, in particular, leukocytes. The molecules of the present invention find broad application inter alia as diagnostic markers for cells, targets for cell therapy and as validated drug targets in order to modulate the immune response and to treat, prevent and diagnose a range of diseases conditions including cancer, genetic disease, inflammatory conditions and conditions associated with aberrant haematopoietic cell function or activity. The present invention extends to binding partners of the instant molecules such as, for example, antibodies, ligands, adaptor and other signalling associated molecules, agonists and antagonists and to methods of screening for same.

Abstract: The present invention relates generally to a novel lectin and to derivatives, homologues, analogues, chemical equivalents and mimetics thereof and, more particularly, to a novel type I C-type lectin, herein referred to as “DCL-1”. In particular, the present invention relates to the use of DCL-1 in therapeutic, prophylactic and diagnostic applications.

Abstract: The present invention relates generally to a method of generating lymphocytes specific for particular antigens. More particularly, the present invention provides a method for generating antigen-reactive T- cells and even more particularly cytotoxic (CD8+) T-cells in 10 vitro specific for antigens such as peptide antigens. The method of the present invention enables in vitro T-cell priming for particular antigens such as antigens on cancer cells, pathogenic cells, viruses or cells infected with viruses. The present invention is useful in identifying particularly immunogenic antigens for immunotherapy. Furthermore, as a consequence, the present invention is useful in avoiding the need for expensive and time 15 consuming clinical trials.

Abstract: The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides molecules having structural features characteristic of immunoregulatory signalling (IRS) molecules and which are expressed by cells of haematopoietic lineages such as, in particular, leukocytes. The molecules of the present invention find broad application inter alia as diagnostic markers for cells, targets for cell therapy and as validated drug targets in order to modulate the immune response and to treat, prevent and diagnose a range of diseases conditions including cancer, genetic disease, inflammatory conditions and conditions associated with aberrant haematopoietic cell function or activity. The present invention extends to binding partners of the instant molecules such as, for example, antibodies, ligands, adaptor and other signalling associated molecules, agonists and antagonists and to methods of screening for same.

Abstract: The present invention relates generally to immuno-interactive agents which are capable of interacting with an epitope on a molecule in or on dendritic cells (DC). More particularly, the present invention provides immunological reagents such as but not limited to immunoglobulin agents which are capable of interacting with an epitope on a molecule present on or within a subset of DC. Generally, the DC are a subset of DC which have been subjected to differentiation stimulus. The resulting differentiated, activated subset of DC produce a molecule comprising an immunologically detectable epitope which is not detectable in non-differentiated DC. The present invention further relates to cell lines which produce the instant immuno-interactive molecules and to a method for identifying and purifying the above-mentioned subset of DC from a biological sample such as blood using the instant immuno-interactive molecules.