Patents by Inventor Derek Pflum

Derek Pflum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of Preparing Sulfinamides and Sulfoxides
    Publication number: 20070293682
    Abstract: This invention encompasses novel methods of preparing sulfinamides and sulfoxides, particularly stereomerically pure sulfinamides and sulfoxides. The invention further encompasses novel compounds from which sulfinamides and sulfoxides can be prepared.
    Type: Application
    Filed: July 30, 2007
    Publication date: December 20, 2007
    Inventors: Chris Senanayake, Zhengxu Han, Dhileepkumar Krishnamurthy, Derek Pflum, Harold Wilkinson
  • Methods of preparing sulfinamides and sulfoxides
    Patent number: 7256297
    Abstract: This invention encompasses novel methods of preparing sulfinamides and sulfoxides, particularly stereomerically pure sulfinamides and sulfoxides. The invention further encompasses novel compounds from which sulfinamides and sulfoxides can be prepared.
    Type: Grant
    Filed: January 27, 2006
    Date of Patent: August 14, 2007
    Assignee: Apsinterm, LLC.
    Inventors: Chris Hugh Senanayake, Zhengxu Han, Dhileepkumar Krishnamurthy, Derek Pflum, Harold Scott Wilkinson
  • Methods of preparing sulfinamides and sulfoxides
    Patent number: 7064214
    Abstract: This invention encompasses novel methods of preparing sulfinamides and sulfoxides, particularly stereomerically pure sulfinamides and sulfoxides. The invention further encompasses novel compounds from which sulfinamides and sulfoxides can be prepared.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: June 20, 2006
    Assignee: Apsinterm LLC
    Inventors: Chris Hugh Senanayake, Zhengxu Han, Dhileepkumar Krishnamurthy, Derek Pflum, Harold Scott Wilkinson
  • Methods of preparing sulfinamides and sulfoxides
    Publication number: 20060128767
    Abstract: This invention encompasses novel methods of preparing sulfinamides and sulfoxides, particularly stereomerically pure sulfinamides and sulfoxides. The invention further encompasses novel compounds from which sulfinamides and sulfoxides can be prepared.
    Type: Application
    Filed: January 27, 2006
    Publication date: June 15, 2006
    Inventors: Chris Senanayake, Zhengxu Han, Dhileepkumar Krishnamurthy, Derek Pflum, Harold Wilkinson
  • Glycosylated indolocarbazole synthesis
    Patent number: 7038043
    Abstract: Indolocarbazoles are furanosylated (e.g., 7) with acetals (e.g., 8) or their open chain congeners (e.g., 9) under conditions known to promote acetal exchange or formation, such as protic or Lewis acids. Furanosylated indolocarbazoles (e.g., 10) are also prepared via ring contraction of pyranosylated indolocarbazoles (e.g., 11) under conditions know to effect oxidation and benzylic acid type rearrangements, and pyranosylated indolocarbazoles (e.g., 11) are prepared via ring expansion of the furanosylated congeners (e.g.
    Type: Grant
    Filed: January 13, 2000
    Date of Patent: May 2, 2006
    Assignee: Yale University
    Inventors: John L. Wood, Brian M. Stoltz, Hans-Jurgen Dietrich, Derek A. Pflum
  • C1-symmetric bisphosphine ligands and their use in the asymmetric synthesis of pregabalin
    Publication number: 20050228190
    Abstract: Materials and methods for preparing (S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid and structurally related compounds via enantioselective hydrogenation of prochiral olefins are disclosed. The methods employ novel chiral catalysts, which include C1-symmetric bisphosphine ligands bound to transition metals.
    Type: Application
    Filed: March 11, 2005
    Publication date: October 13, 2005
    Inventors: Jian Bao, Vladimir Beylin, Derek Greene, Garrett Hoge, William Kissel, Mark Marlatt, Derek Pflum, He-Ping Wu
  • Methods of preparing didesmethylsibutramine and other sibutramine derivatives
    Patent number: 6894189
    Abstract: This invention encompasses novel methods of preparing sibutramine and sibutramine derivatives, and stereomerically pure sibutramine derivatives in particular. Examples of sibutramine derivatives include, but are not limited to, sibutramine metabolites such as desmethylsibutramine and didesmethylsibutramine. The invention further encompasses novel compounds useful in the synthesis of sibutramine derivatives.
    Type: Grant
    Filed: August 20, 2003
    Date of Patent: May 17, 2005
    Assignee: Sepracor Inc.
    Inventors: Chris Hugh Senanayake, Zhengxu Han, Dhileepkumar Krishnamurthy, Derek Pflum
  • Methods of preparing didesmethylsibutramine and other sibutramine derivatives
    Publication number: 20040087660
    Abstract: This invention encompasses novel methods of preparing sibutramine and sibutramine derivatives, and stereomerically pure sibutramine derivatives in particular. Examples of sibutramine derivatives include, but are not limited to, sibutramine metabolites such as desmethylsibutramine and didesmethylsibutramine. The invention further encompasses novel compounds useful in the synthesis of sibutramine derivatives.
    Type: Application
    Filed: August 20, 2003
    Publication date: May 6, 2004
    Applicant: Sepracor Inc.
    Inventors: Chris Hugh Senanayake, Zhengxu Han, Dhileepkumar Krishnamurthy, Derek Pflum
  • Methods of preparing didesmethylsibutramine and other sibutramine derivatives
    Patent number: 6610887
    Abstract: This invention encompasses novel methods of preparing sibutramine and sibutramine derivatives, and stereomerically pure sibutramine derivatives in particular. Examples of sibutramine derivatives include, but are not limited to, sibutramine metabolites such as desmethylsibutramine and didesmethylsibutramine. The invention further encompasses novel compounds useful in the synthesis of sibutramine derivatives.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: August 26, 2003
    Assignee: Sepracor Inc.
    Inventors: Chris Hugh Senanayake, Zhengxu Han, Dhileepkumar Krishnamurthy, Derek Pflum
  • Methods of preparing sulfinamides and sulfoxides
    Publication number: 20030083517
    Abstract: This invention encompasses novel methods of preparing sulfinamides and sulfoxides, particularly stereomerically pure sulfinamides and sulfoxides. The invention further encompasses novel compounds from which sulfinamides and sulfoxides can be prepared.
    Type: Application
    Filed: April 12, 2002
    Publication date: May 1, 2003
    Inventors: Chris Hugh Senanayake, Zhengxu Han, Dhileepkumar Krishnamurthy, Derek Pflum, Harold Scott Wilkinson
  • Methods of preparing didesmethylsibutramine and other sibutramine derivatives
    Publication number: 20020183554
    Abstract: This invention encompasses novel methods of preparing sibutramine and sibutramine derivatives, and stereomerically pure sibutramine derivatives in particular. Examples of sibutramine derivatives include, but are not limited to, sibutramine metabolites such as desmethylsibutramine and didesmethylsibutramine. The invention further encompasses novel compounds useful in the synthesis of sibutramine derivatives.
    Type: Application
    Filed: April 12, 2002
    Publication date: December 5, 2002
    Inventors: Chris Hugh Senanayake, Zhengxu Han, Dhileepkumar Krishnamurthy, Derek Pflum