Patents by Inventor Derek PHAN

Derek PHAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Differentiation of hepatocyte-like cells from stem cells
    Patent number: 10323228
    Abstract: Disclosed are methods of differentiating stem cells in order to obtain hepatocyte-like cells, the method comprising the steps of a) subjecting definitive endoderm to at least one epigenetic modulator to obtain hepatoblasts and b) subjecting the hepatoblasts to at least one stem cell differentiation pathway inhibitor to obtain hepatocyte-like cells; wherein steps a) and b) do not comprise the use of a growth factor. In one preferred embodiment, the epigenetic modulator may be sodium butyrate and/or DMSO and the stem cell differentiation pathway inhibitor may be SB431542 and/or DMSO. Also disclosed are hepatocyte-like cells obtained from the method and uses of these cells such as drug screening.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: June 18, 2019
    Assignee: Agency for Science, Technology and Research
    Inventors: Hanry Yu, Derek Phan, Yi-chin Toh, Farah Tasnim
  • DIFFERENTIATION OF HEPATOCYTE-LIKE CELLS FROM STEM CELLS
    Publication number: 20170260503
    Abstract: Disclosed are methods of differentiating stem cells in order to obtain hepatocyte-like cells, the method comprising the steps of a) subjecting definitive endoderm to at least one epigenetic modulator to obtain hepatoblasts and b) subjecting the hepatoblasts to at least one stem cell differentiation pathway inhibitor to obtain hepatocyte-like cells; wherein steps a) and b) do not comprise the use of a growth factor. In one preferred embodiment, the epigenetic modulator may be sodium butyrate and/or DMSO and the stem cell differentiation pathway inhibitor may be SB431542 and/or DMSO. Also disclosed are hepatocyte-like cells obtained from the method and uses of these cells such as drug screening.
    Type: Application
    Filed: September 17, 2015
    Publication date: September 14, 2017
    Inventors: Hanry YU, Derek PHAN, Yi-chin TOH, Farah TASNIM