Patents by Inventor Derek R. Sutherland
Derek R. Sutherland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5336789Abstract: Compounds of formula (I) ##STR1## and salts thereof wherein R.sup.1 is a methyl, ethyl or isopropyl group;R.sup.2 is a hydrogen atom or a group OR.sup.4 (where OR.sup.4 is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms) and R.sup.3 is a hydrogen atom, or (when R.sup.2 is a hydrogen atom) a bromine atom; or R.sup.2 and R.sup.3 together with the carbon atom to which they are attached represent >C.dbd.CH.sub.2, >C.dbd.O or >C.dbd.NOR.sup.5 (where R.sup.5 is a hydrogen atom, a C.sub.1-8 alkyl group or a C.sub.3-8 alkenyl group and the group >C.dbd.NOR.sup.5 is in the E configuration); andY represents an oxygen atom or a group NOR.sup.5 (where R.sup.5 is as defined above); with the proviso that when Y is an oxygen atom and R.sup.1 is an isopropyl group, then R.sup.2 is other than hydroxyl group.These compounds may be used for controlling insect, acarine, nematode or other pests.Type: GrantFiled: August 27, 1992Date of Patent: August 9, 1994Assignee: American Cyanamid CompanyInventors: Derek R. Sutherland, Michael V. J. Ramsay, Edward P. Tiley, John B. Ward, Neil Porter, Hazel M. Noble, Richard A. Fletton, David Noble, Brian M. Bain
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Patent number: 5192777Abstract: Compounds of formula (I) ##STR1## and salts thereof, wherein R.sup.1 represents a methyl, ethyl or ispropyl group; R.sup.2 represents a C.sub.2-7 alkyl group interrupted by an oxygen or sulphur atom or an aryl, aryl C.sub.1-7 alkyl or heteroaryl C.sub.1-7 alkyl group; OR.sup.3 is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms; and the group .dbd.NOR.sup.2 is in the E configuration.These compounds may be used for controlling insect, acarine, nematode or other pests.Type: GrantFiled: December 11, 1990Date of Patent: March 9, 1993Assignee: American Cyanamid CompanyInventors: Michael V. J. Ramsay, Edward P. Tiley, Derek R. Sutherland
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Patent number: 5185456Abstract: Compounds of formula (I) ##STR1## and salts thereof wherein R.sup.1 is a methyl, ethyl or isopropyl group;R.sup.2 is a hydrogen atom or a group OR.sup.4 (where OR.sup.4 is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms) and R.sup.3 is a hydrogen atom, or (when R.sup.2 is a hydrogen atom) a bromine atom; or R.sup.2 and R.sup.3 together with the carbon atom to which they are attached represent >C.dbd.CH.sub.2, >C.dbd.0 or >C.dbd.NOR.sup.5 (where R.sup.5 is a hydrogen atom, a C.sub.1-8 alkyl group or a C.sub.3-8 alkenyl group and the group >C.dbd.NOR.sup.5 is in the E configuration); andY represents an oxygen atom or a group NOR.sup.5 (where R.sup.5 is as defined above); with the proviso that when Y is an oxygen atom and R.sup.1 is an isopropyl group, then R.sup.2 is other than hydroxyl group.These compounds may be used for controlling insect, acarine, nematode or other pests.Type: GrantFiled: March 18, 1991Date of Patent: February 9, 1993Assignee: American Cyanamid CompanyInventors: Derek R. Sutherland, Michael V. J. Ramsay, Edward P. Tiley, John B. Ward, Neil Porter, Hazel M. Noble, Richard A. Fletton, David Noble, Brian M. Bain
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Patent number: 5116968Abstract: Compounds of formula (1) ##STR1## wherein R represents a sugar residue or an acylated derivative thereof;R.sup.1 represents a methyl, ethyl or isopropyl group;Y.sup.1 is --CH.sub.2, Y.sup.2 is --CH-- and X represents ##STR2## [wherein R.sup.2 represents a hydrogen atom or a group OR.sup.6 (where OR.sup.6 is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms) and R.sup.3 represents a hydrogen atom, or R.sup.2 and R.sup.3 together with the carbon atom to which they are attached represent >C.dbd.0, >C.dbd.CH.sub.2 or >C.dbd.NOR.sup.7 (where R.sup.7 represents a hydrogen atom, a C.sub.1-8 alkyl group or a C.sub.3-8 alkenyl group) and the group >C.dbd.NOR.sup.7 is in the E configuration] or --Y.sup.1 --X--Y.sup.2 -- represents --CH.dbd.CH--CH-- or --CH.sub.2 --CH.dbd.C--; andR.sup.4 represents a group OR.sup.6 as defined above and R.sup.5 represents a hydrogen atom, or R.sup.4 and R.sup.5 together with the carbon atom to which the are attached represent >C.dbd.0 or >C.Type: GrantFiled: December 20, 1990Date of Patent: May 26, 1992Assignee: American Cyanamid CompanyInventors: Gordon C. Lawrence, Michael J. Dawson, David Noble, Michael V. J. Ramsay, Richard Bell, Derek R. Sutherland, Edward P. Tiley
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Patent number: 5112854Abstract: Compounds of formula (1) ##STR1## wherein R.sup.1 represents a methyl, ethyl or isopropyl group; Y.sup.1 is --CH.sub.2 --, Y.sup.2 is --CH-- and X represents ##STR2## [where R.sup.2 represents a hydrogen atom or a group OR.sup.6 (where OR.sup.6 is a hydroxy group or a substituted hydroxyl group having up to 25 carbon atoms) and R.sup.3 represents a hydrogen atom, or R.sup.2 and R.sup.3 together with the carbon atom to which they are attached represent >C.dbd.O, >C.dbd.CH.sub.2 or >C.dbd.NOR.sup.7 (where R.sup.7 represents a hydrogen atom, a C.sub.1-8 alkyl group or a C.sub.3-8 alkenyl group and the group >C.dbd.NOR.sup.7 is in the E configuration)] or --Y.sup.1 --X--Y.sup.2 represents --CH.dbd.CH--CH-- or --CH.sub.2 --CH.dbd.C--; R.sup.4 represents a group OR.sup.6 as defined above and R.sup.5 represents a hydrogen atom, or R.sup.4 and R.sup.5 together with the carbon atom to which they are attached represent >C.dbd.O or >C.dbd.NOR.sup.7a ( where R.sup.7a is as defined above for R.sup.Type: GrantFiled: April 30, 1991Date of Patent: May 12, 1992Assignee: American Cyanamid CompanyInventors: Michael V. J. Ramsay, Richard Bell, Peter D. Howes, Edward P. Tiley, Derek R. Sutherland
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Patent number: 5057536Abstract: Compounds of formula (1) ##STR1## and salts thereof, wherein R.sup.1 represents a methyl, ethyl or isopropyl group;Y.sup.1 is --CH.sub.2 --, Y.sup.2 is --CH-- and X represents ##STR2## where R.sup.2 represents a hydrogen atom or a group OR.sup.8 (where OR.sup.8 is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms) and R.sup.3 represents a hydrogen atom, or R.sup.2 and R.sup.3 together with the carbon atom to which they are attached represent >C.dbd.O, >C.dbd.CH.sub.2 or >C.dbd.NOR.sup.9 (where R.sup.9 represents a hydrogen atom, a C.sub.1-8 alkyl group or a C.sub.3-8 alkenyl group) and the group >C.dbd.NOR.sup.9 is in the E configuration] or --Y.sup.1 --X--Y.sup.2 -- represents --CH.dbd.CH--CH-- or --CH.sub.2 --CH.dbd.C--;R.sup.4 represents a group OR.sup.8 as defined above and R.sup.5 represents a hydrogen atom, or R.sup.4 and R.sup.5 together with the carbon atom to which they are attached represent >C.dbd.O or >C.dbd.NOR.sup.9a (where R.sup.Type: GrantFiled: May 9, 1989Date of Patent: October 15, 1991Assignee: American Cyanamid CompanyInventors: Michael J. Dawson, David Noble, Gordon C. Lawrence, Richard A. Fletton, Stephen J. Lane, Michael V. J. Ramsay, Oswy Z. Pereira, Derek R. Sutherland, Edward P. Tiley
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Patent number: 5034542Abstract: A process for the preparation of a compound of formula (I) ##STR1## (in which R.sup.1 is methyl, ethyl or isopropyl) by hydrogenation of a corresponding compound having a double bond at the 22,23-position, for example in the presence of a rhodium catalyst.Type: GrantFiled: June 9, 1989Date of Patent: July 23, 1991Assignee: American Cyanamid CompanyInventors: Michael V. J. Ramsay, Derek R. Sutherland, John B. Ward, Neil Porter, Hazel M. Noble, Richard A. Fletton, David Noble
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Patent number: 5001145Abstract: Compounds are described of formula (1) ##STR1## and salts thereof wherein R.sup.1 is a methyl, ethyl or isopropyl group;R.sup.2 represents a hydrogen atom or a group OR.sup.4 (where OR.sup.4 is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms) and R.sup.3 represents a hydrogen atom, or R.sup.2 and R.sup.3 together with the carbon atom to which they are attached represent >C.dbd.CH.sub.2, >C.dbd.O or >C.dbd.NOR.sup.5 (where R.sup.5 is a hydrogen atom or a C.sub.1-8 alkyl group and the group >C.dbd.NOR.sup.5 is in the E configuration).These compounds may be used for controlling insect, acarine, nematode or other pests.Type: GrantFiled: January 27, 1989Date of Patent: March 19, 1991Assignee: American Cyanamid CompanyInventors: Michael V. J. Ramsay, Derek N. Evans, Derek R. Sutherland, Edward P. Tiley, John B. Ward, Neil Porter, Hazel M. Noble, Richard A. Fletton, David Noble
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Patent number: 4996228Abstract: Compounds are described of formula (I) ##STR1## and salts therof, wherein R.sup.1 represents a methyl, ethyl or isopropyl group;R.sup.2 is alkyl; alkyl substituted by a carboxy or alkoxycarbonyl; alkenyl; phenyl or phenalkyl;R.sup.3 is --OH;OR.sup.4 is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms.These compounds may be used for controlling insect, acarine, nematode or other pests.Type: GrantFiled: March 11, 1987Date of Patent: February 26, 1991Assignee: American Cyanamid CompanyInventors: Derek R. Sutherland, Michael V. J. Ramsay, John B. Ward, Neil Porter, Hazel M. Noble, Richard A. Fletton, David Noble
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Patent number: 4978675Abstract: Compounds are described of formula (II) ##STR1## and salts thereof, wherein R.sup.1 reprsents a methyl, ethyl or isopropyl group;R.sup.2 represents a hydrogen atom or a group OR.sup.5 (where OR.sup.5 is a hydroxy group or a substituted hydroxyl group having up to 25 carbon atoms) and R.sup.3 represents a hydrogen atom, or R.sup.2 and R.sup.3 together with the carbon atom to which they are attached represent a >C.dbd.0 group; andOR.sup.4 represnts a group OR.sup.5 as defined above;with the proviso that when R.sup.2 represents a hydroxy group OR.sup.4 represents a substituted hydroxy group other than a methoxy group.These compounds may be used for controlling insect, acarine, nematide or other pests.Type: GrantFiled: November 10, 1987Date of Patent: December 18, 1990Assignee: American Cyanamid CompanyInventors: John B. Ward, Hazel M. Noble, Neil Porter, Richard A. Fletton, David Noble, Derek R. Sutherland, Michael V. J. Ramsay
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Patent number: 4950683Abstract: Compounds are described of formula (I) ##STR1## and salts thereof, wherein OR is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms, R.sup.1 represents a methyl, ethyl or isopropyl group and the broken line represents a double bond at the 22,23-position or at the 23,24-position.These compounds may be used for controlling insect, acarine, nematode or other pests.Type: GrantFiled: November 10, 1987Date of Patent: August 21, 1990Assignee: American Cyanamid CompanyInventors: John B. Ward, Hazel M. Noble, Neil Porter, Richard A. Fletton, David Noble, Derek R. Sutherland, Michael V. J. Ramsay
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Patent number: 4918096Abstract: Compounds are described of formula (I) ##STR1## and salts thereof, wherein R.sup.1 represents a methyl, ethyl or isopropyl group; andOR.sup.2 is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms.These compounds may be used for controlling insect, acarine, nematode or other pests.Type: GrantFiled: February 19, 1988Date of Patent: April 17, 1990Assignee: American Cyanamid CompanyInventors: Michael V. J. Ramsey, Brian M. Bain, John B. Ward, Hazel M. Noble, Neil Porter, Richard A. Fletton, David Noble, Derek R. Sutherland, Peter D. Howes
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Patent number: 4918098Abstract: Compounds are described of formula (I) ##STR1## and salts thereof, wherein R.sup.1 a methyl, ethyl or isopropyl group;R.sup.2 is --H, --OH, substituted --OH or a phosphate ester group and R.sup.3 is --H, or R.sup.2 and R.sup.3 together with the carbon atom to which they are attached represent a >C=0 groupand OR.sup.4 is a group OR.sup.5 as defined above;with the proviso that either R.sup.2 represents a group OR.sup.5 (where OR.sup.5 is an alkoxy group OR.sup.7 in which R.sup.7 represents a C.sub.1-6 alkyl substituted by a halogen atom or C.sub.2-6 alkyl interrupted by --O-- or --S--) or at least one of R.sup.2 and OR.sup.4 is a phosphate ester group or a group OCONR.sup.10 R.sup.11 (where R.sup.10 and R.sup.11 are --H or C.sub.1-4 alkyl).These compounds may be used for controlling insect, acarine, nematode or other pests.Type: GrantFiled: March 11, 1987Date of Patent: April 17, 1990Assignee: American Cyanamid CompanyInventors: Michael V. J. Ramsay, Edward P. Tiley, Oswy Z. Pereira, John B. Ward, Neil Porter, Hazel M. Noble, Richard A. Fletton, David Noble, Derek R. Sutherland
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Patent number: 4916153Abstract: Compounds of formula (I): ##STR1## and salts thereof; wherein R.sup.1 is --H, --OH or substituted --OH and R.sup.2 is --H, or R.sup.1 and R.sup.2 together with the carbon atom to which they are attached represent C.dbd.O, C.dbd.CH.sub.2 or C.dbd.NOR.sup.6 in the E configuration (where R.sup.6 is --H, alkyl or alkenyl);R.sup.3 is --OH or substituted --OH and R.sup.4 is --H, or R.sup.3 and R.sup.4 together with the carbon atom to which they are attached represent C.dbd.O;--A--B-- is --C(CH.sub.3).dbd.CH-- or --C(.dbd.CH.sub.2)CHX-- (where X is Cl or Br) andY is --C(R.sup.8).dbd.CHR.sup.7 -- or --C(.dbd.CH.sub.2)CHXR.sup.7 (where X is Cl or Br, R.sup.7 is methyl, ethyl or isopropyl and R.sup.8 is C.sub.2-8 alkyl or C.sub.7-15 phenalkyl); with the proviso that when --A--B-- is (.dbd.CH.sub.2)CHX--, then Y is--C(C.dbd.CH.sub.2)CHXR.sup.7.These compounds may be used for controlling insect, acarine, nematode or other pests.Type: GrantFiled: March 11, 1987Date of Patent: April 10, 1990Assignee: American Cyanamid CompanyInventors: Brian M. Bain, Paul F. Lambeth, Alison C. Rosemeyer, John B. Ward, Neil Porter, Hazel M. Noble, Richard A. Fletton, David Noble, Derek R. Sutherland, Michael V. J. Ramsay, Edward P. Tiley
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Patent number: 4900753Abstract: Compounds are described of formula (I) ##STR1## and salts thereof, wherein R.sup.1 represents a methyl, ethyl or isopropyl group;R.sup.2 represents a hydrogen atom, a C.sub.1-8 alkyl group or a C.sub.3-8 alkenyl group and the group .dbd.NOR.sup.2 is in the E-configuration;OR.sup.3 is a hydroxyl group or a substituted hydroxyl group having up to 25 carbon atoms.These compounds may be used for controlling insect, acarine, nematode or other pests.Type: GrantFiled: June 5, 1987Date of Patent: February 13, 1990Assignee: American Cyanamid CompanyInventors: Derek R. Sutherland, Michael V. J. Ramsay, Edward P. Tiley, Oswy Z. Pereira, John B. Ward, Neil Porter, Hazel M. Noble, Richard A. Fletton, David Noble
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Patent number: 4464368Abstract: Cephalosporin antibiotics of general formula ##STR1## (wherein R.sup.a and R.sup.b, which may be the same or different, each represent a C.sub.1-4 alkyl group, or together with the carbon atom to which they are attached form a C.sub.3-7 cycloalkylidene group and R.sup.1 represents a C.sub.1-4 alkyl group) exhibit broad spectrum antibiotic activity, the activity being unusually high against gram-negative organisms such as strains of Pseudomonas organisms.Particularly effective compounds of formula (I) are (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-(2-carboxyprop-2-oxyimino)acetami do]-3-(2-methylpyrazolium-1-ylmethyl)ceph-3-em-4-carboxylate and (6R,7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-[(1-carboxycyclobut-1-oxyimino)ac etamido]-3-(2-methylpyrazolium-1-ylmethyl)]ceph-3-em-4-carboxylate.Type: GrantFiled: July 23, 1981Date of Patent: August 7, 1984Assignee: Glaxo Group LimitedInventors: Cynthia H. O'Callaghan, Barry E. Ayres, Christopher E. Newall, David G. H. Livermore, Derek R. Sutherland