Patents by Inventor Derek S. Tan

Derek S. Tan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CYTOTOXIC EPOXYKETONE COMPOUNDS, PRECURSORS, COMPOSITIONS, AND METHODS OF USE
    Publication number: 20260234116
    Abstract: The present disclosure relates to epoxyketone compounds according to Formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, P-ketoacid precursors of such epoxyketone compounds, as well as compositions and uses thereof.
    Type: Application
    Filed: April 10, 2024
    Publication date: August 13, 2026
    Inventors: Derek S. Tan, Broderick Cameron Corless, Raphael Geiben
  • Triterpene saponin variants, methods of synthesis and use thereof
    Patent number: 12698304
    Abstract: A number of triterpene saponin variants with different modifications on their central glycosyl ester linkage are described. Also described are methods of making and method of using such triterpene saponin variants.
    Type: Grant
    Filed: April 17, 2023
    Date of Patent: August 4, 2026
    Assignee: Memorial Sloan-Kettering Cancer Center
    Inventors: Derek S. Tan, David Y. Gin, William E. Walkowicz, Alberto Fernandez-Tejada, Govindaswami Ragupathi
  • COMPOSITIONS AND METHODS FOR ADOPTIVE CELL THERAPY FOR CANCER
    Publication number: 20260109675
    Abstract: Provided herein are compositions and methods for adoptive cell therapy comprising engineered immune cells that express a tumor antigen-targeted chimeric antigen receptor and a prodrug converting enzyme.
    Type: Application
    Filed: May 9, 2025
    Publication date: April 23, 2026
    Applicant: MEMORIAL SLOAN KETTERING CANCER CENTER
    Inventors: David A. SCHEINBERG, Thomas J. GARDNER, Derek S. TAN, Jonghan LEE
  • COMPOSITIONS AND METHODS FOR ADOPTIVE CELL THERAPY FOR CANCER
    Publication number: 20260103696
    Abstract: Provided herein are compositions and methods for adoptive cell therapy comprising engineered immune cells that express a tumor antigen-targeted chimeric antigen receptor and a prodrug converting enzyme.
    Type: Application
    Filed: March 3, 2025
    Publication date: April 16, 2026
    Inventors: David A. SCHEINBERG, Thomas J. GARDNER, Derek S. TAN, Jonghan LEE, Ivo LORENZ
  • Compositions and methods for adoptive cell therapy
    Patent number: 12496310
    Abstract: Provided herein are compositions and methods for adoptive cell therapy comprising engineered immune cells that express an antigen-targeted chimeric antigen receptor and a prodrug converting enzyme for the treatment of inflammation, inflammatory diseases, or pathogenic infections.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: December 16, 2025
    Assignee: Memorial Sloan Kettering Cancer Center
    Inventors: David A. Scheinberg, Thomas J. Gardner, Derek S. Tan, Jonghan Lee
  • MINIMAL SAPONIN ANALOGUES, SYNTHESIS AND USE THEREOF
    Publication number: 20250223311
    Abstract: Truncated saponin analogues are disclosed. Also disclosed are pharmaceutical compositions comprising truncated saponin analogues and methods of using the truncated saponin analogues.
    Type: Application
    Filed: January 6, 2025
    Publication date: July 10, 2025
    Inventors: David Y. GIN, Eric K. Chea, Alberto Fernandez-Tejada, Derek S. Tan, Jason S. Lewis, Jeffrey R. Gardner, NagaVaraKishore Pillarsetty
  • Compositions and methods for adoptive cell therapy for cancer
    Patent number: 12241097
    Abstract: Provided herein are compositions and methods for adoptive cell therapy comprising engineered immune cells that express a tumor antigen-targeted chimeric antigen receptor and a prodrug converting enzyme.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: March 4, 2025
    Assignee: Memorial Sloan Kettering Cancer Center
    Inventors: David A. Scheinberg, Thomas J. Gardner, Derek S. Tan, Jonghan Lee, Ivo Lorenz
  • Minimal saponin analogues, synthesis and use thereof
    Patent number: 12187755
    Abstract: Truncated triterpene saponin analogues containing a trisaccharide or tetrasaccharide ester are disclosed. Also disclosed are pharmaceutical compositions comprising truncated saponin analogues and synthetic methods of producing the truncated saponin analogues. Another aspect of the present application relates to a method for immunizing a subject, comprising administering to the subject the pharmaceutical composition comprising a minimal saponin analogue and an antigen.
    Type: Grant
    Filed: March 14, 2022
    Date of Patent: January 7, 2025
    Assignee: MEMORIAL SLOAN-KETTERING CANCER CENTER
    Inventors: David Y. Gin, Eric K. Chea, Alberto Fernandez-Tejada, Derek S. Tan, Jason S. Lewis, Jeffrey R. Gardner, NagaVaraKishore Pillarsetty
  • Compositions and methods for adoptive cell therapy for cancer
    Patent number: 12178830
    Abstract: Provided herein are compositions and methods for adoptive cell therapy comprising engineered immune cells that express a tumor antigen-targeted chimeric antigen receptor and a prodrug converting enzyme.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: December 31, 2024
    Assignee: Memorial Sloan Kettering Cancer Center
    Inventors: David A. Scheinberg, Thomas J. Gardner, Derek S. Tan, Jonghan Lee
  • TRITERPENE SAPONIN VARIANTS, METHODS OF SYNTHESIS AND USE THEREOF
    Publication number: 20230357302
    Abstract: A number of triterpene saponin variants with different modifications on their central glycosyl ester linkage are described. Also described are methods of making and method of using such triterpene saponin variants.
    Type: Application
    Filed: April 17, 2023
    Publication date: November 9, 2023
    Inventors: Derek S. TAN, David Y. GIN, William E. WALKOWICZ, Albertto FERNANDEZ-TEJADA, Govindaswami RAGUPATHI
  • COMPOSITIONS AND METHODS FOR ADOPTIVE CELL THERAPY
    Publication number: 20230190797
    Abstract: Provided herein are compositions and methods for adoptive cell therapy comprising engineered immune cells that express an antigen-targeted chimeric antigen receptor and a prodrug converting enzyme for the treatment of inflammation, inflammatory diseases, or pathogenic infections.
    Type: Application
    Filed: July 2, 2018
    Publication date: June 22, 2023
    Applicant: MEMORIAL SLOAN KETTERING CANCER CENTER
    Inventors: David A. SCHEINBERG, Thomas J. GARDNER, Derek S. TAN, Jonghan LEE, Ivo LORENZ
  • Triterpene saponin variants, methods of synthesis and use thereof
    Patent number: 11629162
    Abstract: A number of triterpene saponin variants with different modifications on their central glycosyl ester linkage are described. Also described are methods of making and method of using such triterpene saponin variants.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: April 18, 2023
    Assignee: Memorial Sloan-Kettering Cancer Center
    Inventors: Derek S. Tan, David Y. Gin, William E. Walkowicz, Alberto Fernandez-Tejada, Govindaswami Ragupathi
  • MINIMAL SAPONIN ANALOGUES, SYNTHESIS AND USE THEREOF
    Publication number: 20220275017
    Abstract: Truncated triterpene saponin analogues containing a trisaccharide or tetrasaccharide ester are disclosed. Also disclosed are pharmaceutical compositions comprising truncated saponin analogues and synthetic methods of producing the truncated saponin analogues. Another aspect of the present application relates to a method for immunizing a subject, comprising administering to the subject the pharmaceutical composition comprising a minimal saponin analogue and an antigen.
    Type: Application
    Filed: March 14, 2022
    Publication date: September 1, 2022
    Inventors: David Y. GIN, Eric K. CHEA, Alberto FERNANDEZ-TEJADA, Derek S. TAN, Jason S. LEWIS, Jeffrey R. GARDNER, NagaVaraKishore PILLARSETTY
  • Minimal saponin analogues, synthesis and use thereof
    Patent number: 11274116
    Abstract: Truncated triterpene saponin analogues containing a trisaccharide or tetrasaccharide ester are disclosed. Also disclosed are pharmaceutical compositions comprising truncated saponin analogues and synthetic methods of producing the truncated saponin analogues. Another aspect of the present application relates to a method for immunizing a subject, comprising administering to the subject the pharmaceutical composition comprising a minimal saponin analogue and an antigen.
    Type: Grant
    Filed: April 20, 2020
    Date of Patent: March 15, 2022
    Assignee: MEMORIAL SLOAN-KETTERING CANCER CENTER
    Inventors: David Y. Gin, Eric K. Chea, Alberto Fernandez-Tejada, Derek S. Tan, Jason S. Lewis, Jeffrey R. Gardner, NagaVarakishore Pillarsetty
  • MINIMAL SAPONIN ANALOGUES, SYNTHESIS AND USE THEREOF
    Publication number: 20210070796
    Abstract: Truncated triterpene saponin analogues containing a trisaccharide or tetrasaccharide ester are disclosed. Also disclosed are pharmaceutical compositions comprising truncated saponin analogues and synthetic methods of producing the truncated saponin analogues. Another aspect of the present application relates to a method for immunizing a subject, comprising administering to the subject the pharmaceutical composition comprising a minimal saponin analogue and an antigen.
    Type: Application
    Filed: April 20, 2020
    Publication date: March 11, 2021
    Inventors: David Y. Gin, Eric K. Chea, Alberto Fernandez-Tejada, Derek S. Tan, Jason S. Lewis, Jeffrey R. Gardner, NagaVaraKishore Pillarsetty
  • COMPOSITIONS AND METHODS FOR ADOPTIVE CELL THERAPY
    Publication number: 20200268794
    Abstract: Provided herein are compositions and methods for adoptive cell therapy comprising engineered immune cells that express an antigen-targeted chimeric antigen receptor and a prodrug converting enzyme for the treatment of inflammation, inflammatory diseases, or pathogenic infections.
    Type: Application
    Filed: July 2, 2018
    Publication date: August 27, 2020
    Applicant: MEMORIAL SLOAN KETTERING CANCER CENTER
    Inventors: David A. SCHEINBERG, Thomas J. GARDNER, Derek S. TAN, Jonghan LEE
  • COMPOSITIONS AND METHODS FOR ADOPTIVE CELL THERAPY FOR CANCER
    Publication number: 20200215111
    Abstract: Provided herein are compositions and methods for adoptive cell therapy comprising engineered immune cells that express a tumor antigen-targeted chimeric antigen receptor and a prodrug converting enzyme.
    Type: Application
    Filed: July 2, 2018
    Publication date: July 9, 2020
    Applicant: MEMORIAL SLOAN KETTERING CANCER CENTER
    Inventors: David A. SCHEINBERG, Thomas J. GARDNER, Derek S. TAN, Jonghan LEE
  • COMPOSITIONS AND METHODS FOR ADOPTIVE CELL THERAPY FOR CANCER
    Publication number: 20200157518
    Abstract: Provided herein are compositions and methods for adoptive cell therapy comprising engineered immune cells that express a tumor antigen-targeted chimeric antigen receptor and a prodrug converting enzyme.
    Type: Application
    Filed: July 2, 2018
    Publication date: May 21, 2020
    Applicant: MEMORIAL SLOAN KETTERING CANCER CENTER
    Inventors: David A. SCHEINBERG, Thomas J. GARDNER, Derek S. TAN, Jonghan LEE, Ivo LORENZ
  • Minimal saponin analogues, synthesis and use thereof
    Patent number: 10626137
    Abstract: Truncated triterpene saponin analogues containing a trisaccharide or tetrasaccharide ester are disclosed. Also disclosed are pharmaceutical compositions comprising truncated saponin analogues and synthetic methods of producing the truncated saponin analogues. Another aspect of the present application relates to a method for immunizing a subject, comprising administering to the subject the pharmaceutical composition comprising a minimal saponin analogue and an antigen.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: April 21, 2020
    Assignee: MEMORIAL SLOAN-KETTERING CANCER CENTER
    Inventors: David Y. Gin, Eric K. Chea, Alberto Fernandez-Tejada, Derek S. Tan, Jason S. Lewis, Jeffrey R. Gardner, NagaVaraKishore Pillarsetty
  • TRITERPENE SAPONIN VARIANTS, METHODS OF SYNTHESIS AND USE THEREOF
    Publication number: 20190010181
    Abstract: A number of triterpene saponin variants with different modifications on their central glycosyl ester linkage are described. Also described are methods of making and method of using such triterpene saponin variants.
    Type: Application
    Filed: December 19, 2016
    Publication date: January 10, 2019
    Inventors: Derek S. TAN, David Y. GIN, William E. WALKOWICZ, Alberto FERNANDEZ-TAJADA, Govindaswami RAGUPATHI