Abstract: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

Abstract: A modular system may include a plurality of magnets that may be provided to self-align a casing with an accessory. Self-alignment of the casing and the accessory may provide a secure connection of the casing with the accessory. At least one detent and at least one locking arm may mate and lock the casing against the accessory in a mounted position. The at least one detent and the at least one locking arm may unlock in an insertion position. Self-alignment may occur when a first set of magnets attracts a second set of magnets in which opposite polarities attract and automatically initiate movement of the casing towards the accessory.

Abstract: The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

Abstract: An ink composition contains a semi-drying solvent; a pigment; an alkyd resin; and an amine-based polymeric dispersant. The composition contains 5 wt% or more of the alkyd resin, based on the total weight of the composition, and 5 wt% or more of the amine-based polymeric dispersant, based on the total weight of the composition.

Abstract: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

Abstract: A securement device for securement of a catheter connecting assembly to a body of a patient wherein the catheter connecting assembly includes two or more ports adapted to be coupled with the catheter, each port being formed by a respective port body wherein the ports are adapted to be fluidly coupled to a catheter hub of a catheter, the securement device comprising: a base having a continuous top surface and a continuous bottom surface wherein at least a portion of the top surface comprises an antimicrobial layer and wherein at least a portion of the bottom surface comprises an adhesive for attachment of the base to the body of the patient and wherein the base is dimensioned to prevent direct contact between said ports and body of the patient; and one or more retention formations located on the top surface of the base for receiving and retaining at least a portion of a housing comprising said one or more port bodies adapted to be coupled with a terminal end of the catheter.

Abstract: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

Abstract: Described herein is a color calibration system and method including a display device including a non-volatile memory, a display screen, and a target sensor. The system and method further can include a computing system in communication with the display device and including a processor, a persistent memory, a temporary memory, and a reference sensor. A calibration matrix can be derived using the reference and target data captured by the target and reference sensors. The calibration matrix can be used to calibrate the target sensor using the calibration matrix.

Abstract: A method of spooling a crane rope (2) onto a crane drum through a crane rope spooling system (1) from a reel (31) under a predetermined back tension is described and includes the steps of: unspooling the crane rope (2) from a reel (31) and passing the crane rope through a tensioning system (10) comprising a primary back tensioner (12) and a secondary back tensioner (16); gripping the crane rope (2) within the secondary back tensioner (16) and thereby preloading the crane rope (2) with tension prior to the crane rope (2) passing through the primary back tensioner (12); and applying a predetermined back tension to the crane rope (2) with the primary back tensioner (12) as the crane rope (2) is being spooled onto the crane drum under the predetermined back tension.

Abstract: The present disclosure provides engineered transaminase polypeptides useful for the synthesis of chiral amine compounds under industrially relevant conditions. The disclosure also provides polynucleotides encoding the engineered transaminase polypeptides, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases for the production of chiral amine compounds.

Abstract: A method for printing onto a substrate is disclosed. An ink is printed onto a liquid polymer layer to form a printed polymer layer. Printed substrates are also disclosed.

Abstract: A modular system may include a plurality of magnets that may be provided to self-align a casing with an accessory. Self-alignment of the casing and the accessory may provide a secure connection of the casing with the accessory. At least one detent and at least one locking arm may mate and lock the casing against the accessory in a mounted position. The at least one detent and the at least one locking arm may unlock in an insertion position. Self-alignment may occur when a first set of magnets attracts a second set of magnets in which opposite polarities attract and automatically initiate movement of the casing towards the accessory.

Abstract: Provided is a method for applying an ink for applying an oil-based ink to a resin composition layer of a target including a base and the resin composition layer formed over a surface of the base, the method including: a pretreatment step of pre-treating the target before the oil-based ink is applied, with at least one surface treatment for improving a wetting/spreading property of the oil-based ink; a step of applying the oil-based ink to the target that has undergone the pretreatment step; and a post-treatment step of post-treating the target after the oil-based ink is applied, with at least one surface treatment for improving a wetting/spreading property of the oil-based ink.

Abstract: Described herein is a color calibration system and method including a display device including a non-volatile memory, a display screen, and a target sensor. The system and method further can include a computing system in communication with the display device and including a processor, a persistent memory, a temporary memory, and a reference sensor. A calibration matrix can be derived using the reference and target data captured by the target and reference sensors. The calibration matrix can be used to calibrate the target sensor using the calibration matrix.

Abstract: The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents.

Abstract: The present disclosure provides engineered transaminase polypeptides useful for the synthesis of chiral amine compounds under industrially relevant conditions. The disclosure also provides polynucleotides encoding the engineered transaminase polypeptides, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases for the production of chiral amine compounds.

Abstract: The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

Abstract: A modular system may include a plurality of magnets that may be provided to self-align a casing with an accessory. Self-alignment of the casing and the accessory may provide a secure connection of the casing with the accessory. At least one detent and at least one locking arm may mate and lock the casing against the accessory in a mounted position. The at least one detent and the at least one locking arm may unlock in an insertion position. Self-alignment may occur when a first set of magnets attracts a second set of magnets in which opposite polarities attract and automatically initiate movement of the casing towards the accessory.