Patents by Inventor Derek Stemple

Derek Stemple has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR TEMPLATE-FREE DOUBLE STRANDED GEOMETRIC ENZYMATIC NUCLEIC ACID SYNTHESIS
    Publication number: 20220340964
    Abstract: The present disclosure provides compositions and methods for template-free double stranded geometric enzymatic nucleic acid synthesis of arbitrarily programmed nucleic acid sequences.
    Type: Application
    Filed: September 21, 2020
    Publication date: October 27, 2022
    Inventors: Derek STEMPLE, Neil BELL, Sylwia MANKOWSKA, Steven HARVEY, Andrew FRASER
  • Recombinase polymerase amplification
    Publication number: 20080076160
    Abstract: This disclosure describe three related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of the bacterial RecA and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed methods has the advantage of not requiring thermocycling or thermophilic enzymes. Further, the improved processivity of the disclosed methods allow amplification of DNA up to hundreds of megabases in length.
    Type: Application
    Filed: August 13, 2007
    Publication date: March 27, 2008
    Applicant: ASM Scientific, Inc.
    Inventors: Niall Armes, Derek Stemple
  • Recombinase polymerase amplification
    Publication number: 20050112631
    Abstract: This disclosure describe three related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of recombinase and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling or thermophilic enzymes. Further, the improved processivity of the disclosed methods may allow amplification of DNA up to hundreds of megabases in length.
    Type: Application
    Filed: September 1, 2004
    Publication date: May 26, 2005
    Inventors: Olaf Piepenburg, Colin Williams, Niall Armes, Derek Stemple