Abstract: The instant disclosure relates to electrophysiology catheters for tissue ablation. In particular, the instant disclosure relates to a cryogenic ablation balloon with safety features that facilitate identification of a leak into an interstitial space between inner and outer balloons as part of the ablation balloon catheter assembly, and prevents egress of cryogenic fluid out of the ablation balloon.

Abstract: An electrical connector includes a plug portion and a receptacle portion. The plug portion includes a plurality of conductive pins, with a portion of each conductive pin surrounded by a non-conductive post. The receptacle portion includes a plurality of conductive pins recessed into a corresponding plurality of recesses within the receptacle portion. When the plug portion is mated to the receptacle portion, the conductive pins of the plug portion are received within the recesses of the receptacle portion and electrically connected to the conductive pins of the receptacle portion. To advantageously increase creepage and clearance between pins, it is desirable for each recess to have a depth sufficient to receive both a conductive pin and a corresponding surrounding non-conductive post when the plug portion is mated to the receptacle portion.

Abstract: An electroporation catheter includes a shaft having a proximal end and a distal end and an electroporation assembly N located at the distal end of the shaft. The electroporation assembly may include at least a first electrode and a non-conductive portion, the non-conductive portion having a first end and a second end, wherein the first end is connected to the shaft and wherein the second end extends radially outward from the first end.

Abstract: A medical device includes a body and at least one electrode disposed thereon. The electrode includes a metallic substrate, such as a platinum group metal, an alloy of platinum group metals, or gold. The surface of the substrate is modified in a manner that increases its effective surface area without inducing bulk heating. For example, the surface of the substrate can be laser textured and/or coated, such as with titanium nitride or iridium oxide.

Abstract: In some aspects, the present disclosure provides a delivery device for delivering a detachable medical implant that comprises an elongated delivery member and a first engagement portion. The first engagement portion comprises a first proximal-facing surface, a first distal-facing surface, and a first lumen that is configured to accommodate an activation wire, wherein at least 50% of a surface area of the first proximal-facing surface is angled away from a proximal end of the first engagement portion. In other aspects, the present disclosure provides a medical delivery system comprising: such a delivery device; an implantable device comprising a medical device portion and a second engagement portion, the second engagement portion comprising a second lumen configured to accommodate an activation wire, a second proximal-facing surface and a second distal-facing surface; and an activation wire. Other aspects pertain to methods of medical device delivery using such a medical delivery system.

Abstract: In some aspects, the present disclosure provides a delivery device for delivering a detachable medical implant that comprises an elongated delivery member and a first engagement portion. The first engagement portion comprises a first proximal-facing surface, a first distal-facing surface, and a first lumen that is configured to accommodate an activation wire, wherein at least 50% of a surface area of the first proximal-facing surface is angled away from a proximal end of the first engagement portion. In other aspects, the present disclosure provides a medical delivery system comprising: such a delivery device; an implantable device comprising a medical device portion and a second engagement portion, the second engagement portion comprising a second lumen configured to accommodate an activation wire, a second proximal-facing surface and a second distal-facing surface; and an activation wire. Other aspects pertain to methods of medical device delivery using such a medical delivery system.

Abstract: Systems and methods for electroporation are provided. An electroporation system includes a catheter including a plurality of electrodes, and a pulse generator coupled to the catheter, the pulse generator configured to generate a waveform to be delivered using at least one of the plurality of electrodes. The waveform includes a first pulse having a first polarity, a first pulse amplitude, and a first pulse width, and a second pulse having a second polarity, a second pulse amplitude, and a second pulse width, wherein the first and second pulses are separated by an interpulse delay, and wherein at least one of i) the first pulse amplitude is different than the second pulse amplitude and ii) the first pulse width is different than the second pulse width.

Abstract: A medical device includes a body and at least one electrode disposed thereon. The electrode includes a metallic substrate, such as a platinum group metal, an alloy of platinum group metals, or gold. The surface of the substrate is modified in a manner that increases its effective surface area without inducing bulk heating. For example, the surface of the substrate can be laser textured and/or coated, such as with titanium nitride or iridium oxide.

Abstract: Systems and methods for electroporation catheters are disclosed herein. An electroporation catheter includes a shaft, and a plurality of splines forming a basket around a distal portion of the shaft, each spline extending between a proximal end that is coupled to the shaft and a distal end that is coupled to the shaft, wherein each spline of the plurality of splines comprises at least one energizable electrode. The electroporation catheter further includes a balloon positioned within the basket formed by the plurality of splines, the balloon selectively inflatable to facilitate securing a position of the plurality of splines.

Abstract: A catheter assembly is constructed by reflow bonding an inner liner and an outer layer. The inner liner defines at least one lumen. The inner liner is made of a gamma-irradiated polymeric material that includes a polyether block amide and a gamma radiation activated cross-linking agent.

Abstract: The instant disclosure relates to electrophysiology catheters for tissue ablation. In particular, the instant disclosure relates to a cryogenic ablation balloon with safety features that facilitate identification of a leak into an interstitial space between inner and outer balloons as part of the ablation balloon catheter assembly, and prevents egress of cryogenic fluid out of the ablation balloon.

Abstract: In some aspects, the present disclosure provides a delivery device for delivering a detachable medical implant that comprises an elongated delivery member and a first engagement portion. The first engagement portion comprises a first proximal-facing surface, a first distal-facing surface, and a first lumen that is configured to accommodate an activation wire, wherein at least 50% of a surface area of the first proximal-facing surface is angled away from a proximal end of the first engagement portion. In other aspects, the present disclosure provides a medical delivery system comprising: such a delivery device; an implantable device comprising a medical device portion and a second engagement portion, the second engagement portion comprising a second lumen configured to accommodate an activation wire, a second proximal-facing surface and a second distal-facing surface; and an activation wire. Other aspects pertain to methods of medical device delivery using such a medical delivery system.

Abstract: Disclosed herein are detachment mechanisms for vaso-occlusive devices that allow for rapid operator-controlled release of the vaso-occlusive device into the selected site. Also disclosed are vaso-occlusive assemblies comprising these detachment mechanisms and methods of using these detachment mechanisms and vaso-occlusive assemblies.

Abstract: A medical device includes a body and at least one electrode disposed thereon. The electrode includes a metallic substrate, such as a platinum group metal, an alloy of platinum group metals, or gold. The surface of the substrate is modified in a manner that increases its effective surface area without inducing bulk heating. For example, the surface of the substrate can be laser textured and/or coated, such as with titanium nitride or iridium oxide.

Abstract: A medical device for ablation of a target tissue is disclosed. The medical device includes a catheter assembly attached to a balloon for the ablation of the target tissue. The catheter assembly includes a proximal end and a distal end. The catheter assembly includes a plurality of individual shafts placed concentrically or adjacent to each other. Further, the plurality of individual shafts includes a respective lumen, wherein the lumens of the plurality of individual shafts can be configured to supply radio frequency (RF) energy to an RF transmitter placed inside the balloon and also to serve as the passageway for a fluid to travel within the balloon. The fluid flowing within the lumens of the catheter assembly can further help in expanding the balloon and transferring energy from the RF transmitter within the balloon to the ablation site via a plurality of windows attached.

Abstract: The present disclosure relates to a high capacity medical device connector utilizing flexible circuits. The use of flexible circuits allows for increased channel capacity for use with future designs and capabilities of medical devices. The assembly may include pre-mounted electrical components. The connector may be designed to connect two flexible circuits. The connector may also be designed to connect a flexible circuit with existing technology, such as a pin-to-socket connector.

Abstract: The present disclosure relates to a high capacity medical device connector utilizing flexible circuits. The use of flexible circuits allows for increased channel capacity for use with future designs and capabilities of medical devices. The assembly may include pre-mounted electrical components. The connector may be designed to connect two flexible circuits. The connector may also be designed to connect a flexible circuit with existing technology, such as a pin-to-socket connector.

Abstract: Disclosed herein are detachment mechanisms for vaso-occlusive devices that allow for rapid operator-controlled release of the vaso-occlusive device into the selected site. Also disclosed are vaso-occlusive assemblies comprising these detachment mechanisms and methods of using these detachment mechanisms and vaso-occlusive assemblies.

Abstract: A subintimal recanalization catheter, including an elongate shaft including a first tubular member and a penetration member slidably disposed in a lumen of the first tubular member. The penetration member includes a distal tip positioned proximal of a distal nose of the first tubular member. The distal nose of the first tubular member includes a ramp and a guide wire lumen extending through the distal nose of the first tubular member. Longitudinal movement of the penetration member relative to the first tubular member causes the penetration member to contact the ramp to direct the distal tip of the penetration member away from the first tubular member.

Abstract: A subintimal recanalization catheter, including an elongate shaft including a first tubular member and a penetration member slidably disposed in a lumen of the first tubular member. The penetration member includes a distal tip positioned proximal of a distal nose of the first tubular member. The distal nose of the first tubular member includes a ramp and a guide wire lumen extending through the distal nose of the first tubular member. Longitudinal movement of the penetration member relative to the first tubular member causes the penetration member to contact the ramp to direct the distal tip of the penetration member away from the first tubular member.