Abstract: This invention relates to protein fibrils, to methods and kits of producing those protein fibrils comprising a plurality of first peptide monomer units arranged in a first strand and a plurality of second peptide monomer units arranged in a second strand in which said first and second strands form an overlapping staggered heterodimer coiled coil structure, and wherein the amino acid residues on the exposed surface of said first and second strands enable said protein fibril to interact with another protein fibril in a plurality of non-parallel orientations. This invention also relates to bundles of protein fibrils and matrices, in particular, hydrogels produced using those protein fibrils.

Abstract: The present invention relates to a fiber-shaping peptides that are capable of interacting with self-assembling peptides to form protein structures. The present invention also relates to methods of forming protein structures using the fiber-shaping peptides of the present invention.

Abstract: The present invention relates to peptides that switch between 2 structural states in response to the presence or absence of a stimulus. The present invention also relates to the use of the peptides of the present invention in an assay to detect the presence or absence of a stimulus. The present invention also relates to a method for constructing the peptides of the present invention.

Abstract: The present invention relates to a fibre-shaping peptides that are capable of interacting with self-assembling peptides to form protein structures. The present invention also relates to methods of forming protein structures using the fibre-shaping peptides of the present invention.

Abstract: The invention provides a method to monitor the activity of an enzyme comprising the step of monitoring the addition to at least one polypeptide of a phosphate moiety. The polypeptide is an isolated polypeptide, or a fragment thereof, comprising a non-natural site sufficient for the addition of a phosphate (PO4). The polypeptide binds to at least one binding partner in a phosphorylation-dependent manner. The polypeptide further comprises a detection means; the polypeptide comprising the detection means is a reporter molecule.

Abstract: This invention relates to protein fibre formation and in particular to methods of producing protein fibres to form a protein structure comprising a plurality of first polypeptide units arranged in a first polypeptide strand and a plurality of second polypeptide units arranged in a second polypeptide strand, the strands preferably forming a coiled coil structure, and in which a first polypeptide unit in the first strand extends beyond a corresponding second polypeptide unit in the second strand in the direction of the strands.