Abstract: A device and method are disclosed for the real-time monitoring and detection of infectious agents in clinical specimens. The device utilizes a sensor array to detect gaseous biosignatures, such as volatile organic compounds (VOCs), released by metabolically active pathogens. A data processing module with an artificial intelligence (AI) algorithm analyzes multi-sensor data to generate a time-resolved biosignature profile. The algorithm interprets this profile to provide diagnostic outputs, including pathogen presence, identity, an estimation of microbial load (e.g., CFU/mL), and, notably, a determination of the microbial growth rate calculated from the profile's change over time. Embodiments of the device include handheld point-of-care analyzers, integrated ‘smart caps’ for specimen containers, and in-line monitors for surgical drains. The technology enables rapid, data-driven clinical decisions for infection management by providing timely and dynamic assessments of microbial activity.

Abstract: A device and method are provided for real-time monitoring and detection of pathogen-associated indicators in or derived from medical drainage systems. The device comprises a sensor array configured to detect a plurality of gaseous analytes present in the headspace associated with drainage fluids, wherein said analytes are indicative of microbial presence, metabolic activity, proliferation, or type. An electronic module operatively connected to the sensor array includes an artificial intelligence (AI)-driven algorithm configured to process sensor data, identify a biosignature profile, and generate outputs including pathogen presence, microbial load estimation, pathogen classification, differentiation between infectious and non-infectious inflammation, or prediction of infection risk. The device further includes means for transmitting data and a user interface. The system can be integrated into various drainage setups or function as a standalone unit.

Abstract: A system for wound monitoring and pathogen detection includes a sensor device having an inlet connected to a NPTW dressing and an outlet connected to a NPTW pump. The sensor device includes a sensor array configured to detect a gaseous emission from one or more pathogens present in a wound by generating signals upon exposure to one or more compounds in the gas phase; a microcontroller (MCU) operatively coupled with the sensor array, the MCU configured to process signals from the sensor array to identify the one or more compounds; a wireless communication component for transmitting data from the MCU to one or more external devices; and one or more visual indicators that presents information comprising an operational mode of the sensor device and a presence or absence of pathogen in the gaseous emission. A method for wound monitoring and pathogen detection is also provided.

Abstract: A stretchable sensor array system includes a stretchable substrate, a sensor array comprising a plurality of sensors deposited on the substrate, and a computing device. Each senor has a conductive electrode that contains one or more carbonaceous materials and is configured to respond to a parameter selecting from pressure, temperature, humidity, and chemical substances, and each sensor is signally connected to the computing device and transmits signals representing the parameter to the computing device for storage and/or processing. The stretchable sensor array system can be used for patient monitoring such as pressuring ulcer monitoring and prevention as well as training simulation such as palpation training and analysis. A training simulator includes one or more stretchable sensor arrays affixed to a manikin, a garment, or a helmet, etc., and provide data reflecting the training activity, e.g., palpation.

Abstract: The invention generally features compositions and methods for modulating an immune response. In particular embodiments, such compositions and methods modulate regulatory T cell suppressive activity.

Abstract: The invention generally features compositions and methods for modulating an immune response. In particular embodiments, such compositions and methods modulate regulatory T cell suppressive activity.

Abstract: The invention generally features compositions and methods for modulating an immune response. In particular embodiments, such compositions and methods modulate regulatory T cell suppressive activity.

Abstract: The invention generally features compositions and methods for modulating an immune response. In particular embodiments, such compositions and methods modulate regulatory T cell suppressive activity.

Abstract: The invention generally features compositions and methods for modulating an immune response. In particular embodiments, such compositions and methods modulate regulatory T cell suppressive activity.