Patents by Inventor Derin C. Walters
Derin C. Walters has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200080073Abstract: An electroporation apparatus and its novel chamber with inlet ports for mixing cells and exogenous material. The inlet ports are oriented in nonparallel to each other immediately adjacent at the same top comer of the first wall of the chamber. The mixing chamber comprises successive wall sections, two curved walls at its bottom; the first curved comer is on the same side of the chamber where the liquids enter the chamber, and directs the liquids to the second curved comer at the opposing side of the chamber, which in turn further redirects the mixing to the first curved corner. The direction of the liquid flow mixture change direction at least twice into the mixing chamber.Type: ApplicationFiled: October 17, 2019Publication date: March 12, 2020Applicant: CELLECTIS S. A.Inventors: Alan D. King, Richard E. Walters, Stephen B. Deitz, Donald J. Rodis, Derin C. Walters
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Patent number: 10494626Abstract: An electroporation apparatus and its novel chamber with inlet ports for mixing cells and exogenous material. The inlet ports are oriented in nonparallel to each other immediately adjacent at the same top corner of the first wall of the chamber. The mixing chamber comprises successive wall sections, two curved walls at its bottom; the first curved corner is on the same side of the chamber where the liquids enter the chamber, and directs the liquids to the second curved corner at the opposing side of the chamber which in turn further redirects the mixing to the first curved corner. The direction of the liquid flow mixture change direction at least twice into the mixing chamber.Type: GrantFiled: May 11, 2011Date of Patent: December 3, 2019Assignee: CELLECTIS S.A.Inventors: Alan D King, Stephen B Deitz, Donald J Rodis, Jr., Derin C Walters, Robert J Walters
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Patent number: 8979818Abstract: An object of the invention is to provide a method and apparatus for the delivery of polynucleotide vaccines into mammalian skin cells to increase T cell response and to reduce pain and discomfort due to long electric waveform application and due to muscle contractions. The method for the delivery of polynucleotide vaccines into mammalian skin cells includes the steps of: (a.) administering a polynucleotide vaccine into the skin at an administration site, (b.) applying a needle electrode to the skin in the vicinity to the administration site, and (c.) applying a sequence of at least three single, operator-controlled, independently programmed, narrow interval electrical waveforms, which have pulse intervals that are less than 100 milliseconds, to deliver the polynucleotide vaccine into the skin cells by electroporation.Type: GrantFiled: March 15, 2011Date of Patent: March 17, 2015Assignee: CellectisInventors: Derin C. Walters, Alan D. King, Anna-Karin Roos, Robert J. Walters
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Publication number: 20130123744Abstract: The invention provides a method and apparatus for the delivery of polynucleotide cancer vaccines to increase T cell response and reduce pain due to long electric waveform application and muscle contractions. The method includes the steps of: (a.) administering a polynucleotide cancer vaccine into the skin at an administration site, (b.) applying a needle electrode to the skin in the vicinity of the administration site, and (c.) applying a sequence of at least three electrical waveforms to deliver the polynucleotide cancer vaccine into skin cells by electroporation. The sequence has at least one of the following characteristics {1} at least two of the waveforms differ in amplitude, {2} at least two of the waveforms differ in width, and (3) a first waveform interval for a first set of two of the waveforms is different from a second waveform interval for a second set of two of the waveforms.Type: ApplicationFiled: March 26, 2010Publication date: May 16, 2013Inventors: Derin C. Walters, Alan D. King, Anna-Karin Maltais (formerly Anna-Karin Roos), Britta Wahren, Kristian Haller (formerly Kristian Hallermalm), Andreas Brave, Robert J. Walters
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Publication number: 20110282265Abstract: An object of the invention is to provide a method and apparatus for the delivery of polynucleotide vaccines into mammalian skin cells to increase T cell response and reduce pain and discomfort due to long electric waveform application and due to muscle contractions. The method includes administering a polynucleotide vaccine into the skin at an administration site, (b) applying a needle electrode to the skin in the vicinity to the administration site, and (c) applying a sequence of at least three single, operator-controlled, independently programmed, narrow interval electrical waveforms, which have pulse intervals that are less than 100 milliseconds, to deliver the 15 polynucleotide vaccine into the skin cells by electroporation.Type: ApplicationFiled: May 20, 2008Publication date: November 17, 2011Inventors: Richard E. Walters, Derin C. Walters, Alan D. King, Anna-Karin Roos
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Publication number: 20110166501Abstract: An object of the invention is to provide a method and apparatus for the delivery of polynucleotide vaccines into mammalian skin cells to increase T cell response and to reduce pain and discomfort due to long electric waveform application and due to muscle contractions. The method for the delivery of polynucleotide vaccines into mammalian skin cells includes the steps of: (a.) administering a polynucleotide vaccine into the skin at an administration site, (b.) applying a needle electrode to the skin in the vicinity to the administration site, and (c.) applying a sequence of at least three single, operator-controlled, independently programmed, narrow interval electrical waveforms, which have pulse intervals that are less than 100 milliseconds, to deliver the polynucleotide vaccine into the skin cells by electroporation.Type: ApplicationFiled: March 15, 2011Publication date: July 7, 2011Inventors: Richard E. Walters, Derin C. Walters, Alan D. King, Anna-Karin Roos
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Patent number: 7689641Abstract: Method, apparatus, and program means for performing a packed multiply high with round and shift operation. The method of one embodiment comprises receiving a first operand having a first set of L data elements. A second operand having a second set of L data elements is received. L pairs of data elements are multiplied together to generate a set of L products. Each of the L pairs includes a first data element from the first set of L data element and a second data element from a corresponding data element position of the second set of L data elements. Each of the L products are rounded to generate L rounded values. Each of said L rounded values are scaled to generate L scaled values. Each of the L scaled values are truncated for storage at a destination. Each truncated value is to be stored at a data element position corresponding to its pair of data elements.Type: GrantFiled: June 30, 2003Date of Patent: March 30, 2010Assignee: Intel CorporationInventors: James C. Abel, Derin C. Walters, Jonathan J. Tyler
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Patent number: 6916656Abstract: An object of the invention is to provide a method of treating biological cells prior to subjecting the biological cells to cell fusion pulses which includes the step of treating the biological cells with pre-fusion electric field waveforms which change amplitude in a non-linear way with respect to time, such that the biological cells are first aligned with a relatively low amplitude, long duration pre-fusion electric field waveform and then compressed with a relatively high amplitude, short duration pre-fusion electric field waveform resulting in increased cell membrane contact prior to being subjected to cell fusion. The non-linear pre-fusion electric field waveforms can change in a stepped way, in a continuous way, in a sigmoidal way, with step-wise increasing waveforms in adjacent steps, with step-wise increasing waveforms in non-adjacent steps, and in accordance with non-linear algorithms.Type: GrantFiled: April 5, 2002Date of Patent: July 12, 2005Assignee: Cyto Pulse Sciences, Inc.Inventors: Richard E. Walters, Derin C. Walters, Alan D. King
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Publication number: 20040267857Abstract: Method, apparatus, and program means for performing a packed multiply high with round and shift operation. The method of one embodiment comprises receiving a first operand having a first set of L data elements. A second operand having a second set of L data elements is received. L pairs of data elements are multiplied together to generate a set of L products. Each of the L pairs includes a first data element from the first set of L data element and a second data element from a corresponding data element position of the second set of L data elements. Each of the L products are rounded to generate L rounded values. Each of said L rounded values are scaled to generate L scaled values. Each of the L scaled values are truncated for storage at a destination. Each truncated value is to be stored at a data element position corresponding to its pair of data elements.Type: ApplicationFiled: June 30, 2003Publication date: December 30, 2004Inventors: James C. Abel, Derin C. Walters, Jonathan J. Tyler
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Patent number: 6653114Abstract: The object of the invention is to provide a method and apparatus for treating membrane-containing material with electrical fields, in vitro, and with an added treating substance. With the method, a plurality of electrodes are arrayed around the material to be treated and are connected to outputs of an electrode selection apparatus. Inputs of the electrode selection apparatus are connected to outputs of a pulse sequence generator. A treating substance is added to the membrane-containing material. Electrical pulses are applied to the electrode selection apparatus and are routed through the electrode selection apparatus in a predetermined, computer-controlled sequence to selected electrodes in the array of electrodes, whereby the membrane-containing material is treated with the added treating substance and with electrical fields. The routing of applied pulses through the electrode selection apparatus to selected electrodes can be done in an enormous number of ways.Type: GrantFiled: October 7, 2002Date of Patent: November 25, 2003Inventors: Richard E. Walters, Alan D. King, Derin C. Walters
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Publication number: 20030159943Abstract: The object of the invention is to provide a method and apparatus for treating membrane-containing material with electrical fields, in vitro, and with an added treating substance. With the method, a plurality of electrodes are arrayed around the material to be treated and are connected to outputs of an electrode selection apparatus. Inputs of the electrode selection apparatus are connected to outputs of a pulse sequence generator. A treating substance is added to the membrane-containing material. Electrical pulses are applied to the electrode selection apparatus and are routed through the electrode selection apparatus in a predetermined, computer-controlled sequence to selected electrodes in the array of electrodes, whereby the membrane-containing material is treated with the added treating substance and with electrical fields. The routing of applied pulses through the electrode selection apparatus to selected electrodes can be done in an enormous number of ways.Type: ApplicationFiled: October 7, 2002Publication date: August 28, 2003Applicant: Cyto Pulse Sciences, Inc.Inventors: Richard E. Walters , Alan D. King , Derin C. Walters
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Publication number: 20030070939Abstract: The object of the invention is to provide a method and apparatus for treating membrane-containing material with electrical fields, in vitro, and with an added treating substance. With the method, a plurality of electrodes are arrayed around the material to be treated and are connected to outputs of an electrode selection apparatus. Inputs of the electrode selection apparatus are connected to outputs of a pulse sequence generator. A treating substance is added to the membrane-containing material. Electrical pulses are applied to the electrode selection apparatus and are routed through the electrode selection apparatus in a predetermined, computer-controlled sequence to selected electrodes in the array of electrodes, whereby the membrane-containing material is treated with the added treating substance and with electrical fields. The routing of applied pulses through the electrode selection apparatus to selected electrodes can be done in an enormous number of ways.Type: ApplicationFiled: October 7, 2002Publication date: April 17, 2003Inventors: Richard E. Walters, Alan D. King, Derin C. Walters
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Patent number: 6117660Abstract: The object of the invention is to provide a method and apparatus for treating membrane containing material with electrical fields and with an added treating substance. With the method, a plurality of electrodes (121-128) are arrayed around the material to be treated and are connected to outputs of an electrode selection apparatus (110). Inputs of the electrode selection apparatus are connected to outputs of an agile pulse sequence generator. A treating substance is added to the membrane-containing material. Electrical pulses are applied to the electrode selection apparatus and are routed through the electrode selection apparatus in a predetermined, computer-controlled sequence to selected electrodes in the array of electrodes, whereby the membrane containing material is treated with the added treating substance and with electrical fields of sequentially varying directions.Type: GrantFiled: February 10, 1999Date of Patent: September 12, 2000Assignee: CytoPulse Sciences, Inc.Inventors: Richard E. Walters, Alan D. King, Derin C. Walters