Patents by Inventor Derk Hogenkamp

Derk Hogenkamp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ALPHA 7 NICOTINIC ACETYLCHOLINE ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF
    Publication number: 20150119402
    Abstract: The present application is related to compounds represented by Formula I, which are novel positive allosteric modulators of al nAChRs. The application also discloses the treatment of disorders that are responsive to enhancement of acetylcholine action on al nAChRs in a mammal by administering an effective amount of a compound of Formula I.
    Type: Application
    Filed: May 8, 2013
    Publication date: April 30, 2015
    Inventor: Derk Hogenkamp
  • Enantiomerically pure S-etifoxine, pharmaceutical compositions thereof and methods of their use
    Patent number: 8110569
    Abstract: Enantiomerically pure S-etifoxine and pharmaceutically acceptable salts, solvates, hydrates or prodrugs thereof are provided. Also provided are pharmaceutical compositions comprising the compounds and methods of treating disorders associated with central nervous system using the compounds and pharmaceutical compositions.
    Type: Grant
    Filed: March 20, 2007
    Date of Patent: February 7, 2012
    Assignee: The Regents of the University of California
    Inventors: David Putman, Derk Hogenkamp, Olivier Dasse, Edward R. Whittemore, Mark S. Jensen
  • Enantiomerically pure S-etifoxine, pharmaceutical compositions thereof and methods of their use
    Publication number: 20080038331
    Abstract: Enantiomerically pure S-etifoxine and pharmaceutically acceptable salts, solvates, hydrates or prodrugs thereof are provided. Also provided are pharmaceutical compositions comprising the compounds and methods of treating disorders associated with central nervous system using the compounds and pharmaceutical compositions.
    Type: Application
    Filed: March 20, 2007
    Publication date: February 14, 2008
    Inventors: David Putman, Derk Hogenkamp, Olivier Dasse, Edward Whittemore, Mark Jensen
  • Enantiomerically pure R-etifoxine, pharmaceutical compositions thereof and methods of their use
    Publication number: 20080039453
    Abstract: Enantiomerically pure R-etifoxine and pharmaceutically acceptable salts, solvates, hydrates or prodrugs thereof are provided. Also provided are pharmaceutical compositions comprising the compounds and methods of treating disorders associated with central nervous system using the compounds and pharmaceutical compositions.
    Type: Application
    Filed: March 20, 2007
    Publication date: February 14, 2008
    Inventors: David Putman, Derk Hogenkamp, Olivier Dasse, Edward Whittemore, Mark Jenson
  • Substituted enaminones, their derivatives and uses thereof
    Publication number: 20060293329
    Abstract: The present invention is related substituted enaminones represented by a compound of Formula I that are novel allosteric modulators of ?7 nAChRs. The invention also discloses the treatment of disorders that are responsive to enhancement of acetylcholine action on ?7 nAChRs in a mammal by administering an effective amount of a compound of Formula I.
    Type: Application
    Filed: June 15, 2006
    Publication date: December 28, 2006
    Inventors: Derk Hogenkamp, Timothy Johnstone, Kelvin Gee
  • Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof
    Publication number: 20060178516
    Abstract: Substituted quinolone carboxylic acids and their derivatives are described. These compounds modulate the effect of ?-aminobutyric acid (GABA) via a novel site on the GABAA receptor complex in a therapeutically relevant fashion and may be used to ameliorate CNS disorders amenable to modulation of the GABAA receptor complex.
    Type: Application
    Filed: May 12, 2003
    Publication date: August 10, 2006
    Inventors: Timothy Johnstone, Derk Hogenkamp, Kelvin Gee
  • 3 ALPHA-HYDROXY-3 BETA-METHOXYMETHYL-SUBSTITUTED STEROIDS AND THE USE THEREOF
    Publication number: 20050171074
    Abstract: This invention relates to compounds having the Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein: R1 is H or methyl; R2 is 5?- or 5?-H; R3 is an optionally substituted N-attached heteroaryl group or a group —X—R4; R4 is an optionally substituted carbon-attached heteroaryl group; and X is O, S or N. The invention also is directed to the use of 3?-hydroxy-3?-methoxymethyl-substituted steroids as sedative/hypnotics and for inducing anesthesia.
    Type: Application
    Filed: January 3, 2005
    Publication date: August 4, 2005
    Inventor: Derk Hogenkamp
  • Aryl substituted pyridines, pyrimidines, pyrazines and triazines and the use thereof
    Publication number: 20050043305
    Abstract: This invention relates aryl substituted pyridines, pyrimidines, pyrazines and triazines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein A1, A2, A3, R1—R4, X and Y are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
    Type: Application
    Filed: September 29, 2004
    Publication date: February 24, 2005
    Applicant: Euro-Celtique S.A.
    Inventors: Derk Hogenkamp, Phong Nguyen, Bin Shao
  • Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof
    Patent number: 6737418
    Abstract: This invention relates to compounds having the Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and R5-R13 are set in the specification. The invention also is directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
    Type: Grant
    Filed: April 30, 2002
    Date of Patent: May 18, 2004
    Assignee: Euro-Celtique S.A.
    Inventors: Derk Hogenkamp, Ravindra Upasani, Phong Nguyen
  • 3Alpha-hydroxy-3beta-methoxymethyl-substituted steroids and the use thereof
    Publication number: 20040034002
    Abstract: This invention relates to compounds having the Formula I: 1
    Type: Application
    Filed: August 15, 2003
    Publication date: February 19, 2004
    Applicant: Euro-Celtique S.A.
    Inventor: Derk Hogenkamp
  • Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof
    Publication number: 20030069292
    Abstract: This invention relates to compounds having the Formula I: 1
    Type: Application
    Filed: April 30, 2002
    Publication date: April 10, 2003
    Applicant: EURO-CELTIQUE S.A.
    Inventors: Derk Hogenkamp, Ravindra Upasani, Phong Nguyen
  • Aryl substituted pyrazoles, and pyrroles, and the use thereof
    Patent number: 6414011
    Abstract: This invention relates to compounds having the Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and R5-R13 are set in the specification. The invention also is directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
    Type: Grant
    Filed: March 24, 2000
    Date of Patent: July 2, 2002
    Assignee: Euro-Celtique S.A.
    Inventors: Derk Hogenkamp, Ravindra Upasani, Phong Nguyen
  • Methods for allosteric modulation of the GABA receptor by members of the androstane and pregnane series
    Patent number: 6277838
    Abstract: Methods, compositions, and compounds for modulating the GABAA receptor-chloride ionophore complex to alleviate stress, anxiety, seizures, mood disorders, PMS and PND and to induce anesthesia.
    Type: Grant
    Filed: April 11, 2000
    Date of Patent: August 21, 2001
    Assignee: Cocensys, Inc.
    Inventors: Ravindra B. Upasani, Haiji Xia, Derk Hogenkamp
  • Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series
    Patent number: 6143736
    Abstract: Methods, compositions, and compounds for modulating the GABA.sub.A receptor-chloride ionophore complex to alleviate stress, anxiety, seizures, mood disorders, PMS and PND and to induce anesthesia.
    Type: Grant
    Filed: July 8, 1999
    Date of Patent: November 7, 2000
    Assignee: CoCensys, Inc.
    Inventors: Ravindra B. Upasani, Haiji Xia, Derk Hogenkamp
  • Method, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series
    Patent number: 5939545
    Abstract: Methods, compositions, and compounds for modulating the GABA.sub.A receptor-chloride ionophore complex to alleviate stress, anxiety, seizures, mood disorders, PMS and PND and to induce anesthesia.
    Type: Grant
    Filed: July 2, 1997
    Date of Patent: August 17, 1999
    Assignee: CoCensys, Inc.
    Inventors: Ravindra B. Upasani, Haiji Xia, Derk Hogenkamp