Patents by Inventor Derk J Bergsma

Derk J Bergsma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6207800
    Abstract: HNFDY20 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HNFDY20 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
    Type: Grant
    Filed: February 9, 1999
    Date of Patent: March 27, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Derk J. Bergsma, Ganesh M. Sathe, Wendy S. Fuetterer, Joyce Y. Mao
  • Patent number: 6174994
    Abstract: Novel 7TM receptor (H2CAA71) polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Novel 7TM receptor (H2CAA71) polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
    Type: Grant
    Filed: September 15, 1998
    Date of Patent: January 16, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Nabil A Elshourbagy, Xiaotong Li, Derk J Bergsma
  • Patent number: 6159700
    Abstract: Human GPR14 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human GPR14 polypeptides and polynucleotides in the design of protocols for the treatment of ischemic coronary artery disease (angina and myocardial infarction); atherosclerosis; metabolic diseases (e.g. diabetes); CHF/myocardial dysfunction; arrhythmias; restenosis; hypertension; hypotension; pulmonary disease (hypertension, COPD, asthma); fibrotic vasculopathies (diabetes, SLE, AS, Reynaud's); cerebrovascular events (e.g. hemnorrhagic and ischemic stroke); neurogenic inflammation/migraine; hematopoictic disorders; ARDS; cancer; autoimmune diseases (e.g. HIV-1 and -2 infection and AIDS); gastrointestinal and genitourinary disturbances (e.g. ulcers) endocrine disorders; fibroproliferative disorders (e.g. psoriasis); inflammatory disease (e.g.
    Type: Grant
    Filed: January 15, 1999
    Date of Patent: December 12, 2000
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc, SB Laboratoires Pharmaceutiques
    Inventors: Nambi V Aiyar, Robert S Ames, Anne Romanic Arnold, Kamal Al-Barazanji, Derk J Bergsma, Jon Chambers, Stephen A Douglas, James J Foley, Bernard Gout, Nassirah Khandoudi, Henry M Sarau, Usman Shabon, Robert N Willette
  • Patent number: 6114127
    Abstract: HDPXU17 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods of screening for agonists and antagonists of the interaction between the HDPXU17 receptor and its ligands, dexoyadenosine triphosphate ("dATP"), deoxyadenosine monophosphate ("dAMP"), and uridine triphosphate ("UTP").
    Type: Grant
    Filed: December 8, 1998
    Date of Patent: September 5, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Derk J. Bergsma, Jeffrey S. Culp, Wendy S. Halsey, Ganesh M. Sathe, Da-Yuan Wang
  • Patent number: 6071722
    Abstract: AXOR1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing AXOR1 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: February 16, 1999
    Date of Patent: June 6, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Nabil Elshourbagy, Usman Shabon, Derk J Bergsma
  • Patent number: 6020157
    Abstract: HFGAN72X polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HFGAN72X polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthema; Parkinson's disease; acute heart failure; hypotension; hypertension; unary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
    Type: Grant
    Filed: April 30, 1997
    Date of Patent: February 1, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Derk J. Bergsma, Catherine Elizabeth Ellis
  • Patent number: 6001963
    Abstract: Polypeptides of HFGAN72 receptor ligands and polynucleotides encoding the polypeptides are provided. Methods of using these polypeptides to diagnose diseases relating to the under- or over-expression of HFGAN72 receptor ligands are also provided. In addition, methods of identifying agonists or antagonists of the interaction of HFGAN72 receptor ligands with the HFGAN72 receptor are provided. Methods of treatment by administering the identified agonists or antagonists to patients in need thereof are further disclosed.
    Type: Grant
    Filed: September 26, 1997
    Date of Patent: December 14, 1999
    Assignees: SmithKline Beecham Corporation, University of Texas Southwestern Medical Center at Dallas
    Inventors: Derk J. Bergsma, Masashi Yanagisawa
  • Patent number: 5981223
    Abstract: HDPXU17 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HDPXU17 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; diabetes, obesity; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infraction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
    Type: Grant
    Filed: January 20, 1998
    Date of Patent: November 9, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Ganesh M Sathe, Wendy S Halsey, Derk J Bergsma
  • Patent number: 5955308
    Abstract: HEOAD54 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HEOAD54 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infraction; ulcers;astma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourettt's syndrome, among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: October 23, 1997
    Date of Patent: September 21, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Derk J Bergsma, Wendy S Halsey, Jeffrey L Mooney, Ganesh M Sathe
  • Patent number: 5942416
    Abstract: HNFDY20 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HNFDY20 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
    Type: Grant
    Filed: March 19, 1997
    Date of Patent: August 24, 1999
    Assignee: Smithkline Beecham Corporation
    Inventors: Derk J. Bergsma, Ganesh M. Sathe, Wendy S. Fuetterer, Joyce Y. Mao
  • Patent number: 5935814
    Abstract: HFGAN72Y polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HFGAN72Y polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
    Type: Grant
    Filed: April 30, 1997
    Date of Patent: August 10, 1999
    Assignee: Smithkline Beecham Corporation
    Inventors: Derk J. Bergsma, Catherine Elizabeth Ellis
  • Patent number: 5912335
    Abstract: Human HUVCT36 polypeptides and DNA (RNA) encoding such HUVCT36 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such HUVCT36 for the treatment of infections, such as bacterial, fungal, protozoan and viral infections, particularly infection caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's, among others, are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides.
    Type: Grant
    Filed: October 3, 1996
    Date of Patent: June 15, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Derk J. Bergsma, Catherine E. Ellis
  • Patent number: 5910430
    Abstract: HTADX50 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HTADX50 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
    Type: Grant
    Filed: January 24, 1997
    Date of Patent: June 8, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Derk J. Bergsma, Catherine E. Ellis
  • Patent number: 5871967
    Abstract: HNHCI32 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HNHCI32 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
    Type: Grant
    Filed: January 24, 1997
    Date of Patent: February 16, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Usman Shabon, Derk J. Bergsma, Ganesh M. Sathe
  • Patent number: 5858716
    Abstract: Novel 7TM receptor (H2CAA71) polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Novel 7TM receptor (H2CAA71) polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthna; Parkion's disease; acute heart failure; hypotension; hypertension; uinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
    Type: Grant
    Filed: May 30, 1997
    Date of Patent: January 12, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Nabil A. Elshourbagy, Xiaotong Li, Derk J. Bergsma
  • Patent number: 5834587
    Abstract: Human HLTEX11 polypeptides and DNA (RNA) encoding such HLTEX11 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such HLTEX11 for the treatment of atherosclerosis, inflammatory conditions, and infections, particularly viral infections, such as AIDS, among others, among others, are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the HLTEX11 and for detecting altered levels of the polypeptide in a host.
    Type: Grant
    Filed: October 8, 1996
    Date of Patent: November 10, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Winnie Chan, Derk J. Bergsma, Catherine E. Ellis
  • Patent number: 5824504
    Abstract: Human HBMBU14 polypeptides and DNA (RNA) encoding such HBMBU14 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such HBMBU14 for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 and HIV-2, pain, cancers, anorexia, bulimia, asthma, Parkinson's disease, acute heart failure, atherosclerosis, hypotension, hypertension, urinary retention, osteoporosis, angina pectoris, myocardial infarction, ulcers, asthma, allergies, benign prostatic hypertrophy and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia or severe mental retardation, and dyskinesias, such as Huntington's disease or Gilles dela Tourette's syndrome, among others, are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides.
    Type: Grant
    Filed: October 31, 1996
    Date of Patent: October 20, 1998
    Inventors: Nabil A. Elshourbagy, Derk J. Bergsma, Catherine E. Ellis