Patents by Inventor Derk J. Hogenkamp

Derk J. Hogenkamp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted heterocycles and their use as allosteric modulators of nicotinic and GABAreceptors
    Patent number: 8865719
    Abstract: The present invention is related to heterocycles represented by a compound of Formula I that are novel allosteric modulators of ?7 nAChRs and/or GABAA receptors. The invention also discloses the treatment of disorders that are responsive to enhancement of acetylcholine action on ?7 nAChRs and negative allosteric modulation of GABAA receptors in a mammal by administering an effective amount of a compound of Formula I.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: October 21, 2014
    Assignee: The Regents of the University of California
    Inventors: Timothy B. C. Johnstone, Derk J. Hogenkamp, Kelvin W. Gee
  • NOVEL 17B-HETEROARYL-SUBSTITUTED STEROIDS AS MODULATORS OF GABAA RECEPTORS
    Publication number: 20140148412
    Abstract: The invention is directed to novel 17?-heteroaryl substituted steroids of Formula I, pharmaceutical compositions thereof, and their use as modulators of GABAA receptors.
    Type: Application
    Filed: January 29, 2014
    Publication date: May 29, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CLAIFORNIA
    Inventor: Derk J. Hogenkamp
  • Substituted enaminones, their derivatives and uses thereof
    Patent number: 7825278
    Abstract: The invention relates to substituted enaminones of Formula I and their derivatives and the discovery that these compounds modulate the effect of ?-aminobutyric acid (GABA) on the GABAA receptor complex in a therapeutically relevant fashion and may be used to ameliorate CNS disorders amenable to modulation of the GABAA receptor complex.
    Type: Grant
    Filed: May 5, 2005
    Date of Patent: November 2, 2010
    Assignee: The Regents of the University of California
    Inventors: Derk J. Hogenkamp, Timothy B. C. Johnstone, Kelvin W. Gee
  • Substituted enaminones, their derivatives and uses thereof
    Patent number: 7820663
    Abstract: The present invention is related substituted enaminones represented by a compound of Formula I that are novel allosteric modulators of ?7 nAChRs. The invention also discloses the treatment of disorders that are responsive to enhancement of acetylcholine action on ?7 nAChRs in a mammal by administering an effective amount of a compound of Formula I.
    Type: Grant
    Filed: June 15, 2006
    Date of Patent: October 26, 2010
    Assignee: The Regents of the University of California
    Inventors: Derk J. Hogenkamp, Timothy B. C. Johnstone, Kelvin W. Gee
  • Substituted Quinolone Carboxylic Acids, Their Derivatives, Site of Action, And Uses Thereof
    Publication number: 20080176897
    Abstract: Substituted quinolone carboxylic acids and their derivatives are described. These compounds modulate the effect of ?-aminobutyric acid (GABA) via a novel site on the GABAA receptor complex in a therapeutically relevant fashion and may be used to ameliorate CNS disorders amenable to modulation of the GABAA receptor complex.
    Type: Application
    Filed: February 15, 2008
    Publication date: July 24, 2008
    Inventors: Timothy B.C. Johnstone, Derk J. Hogenkamp, Kelvin W. Gee
  • Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof
    Patent number: 7355047
    Abstract: Substituted quinolone carboxylic acids and their derivatives are described. These compounds modulate the effect of ?-aminobutyric acid (GABA) via a novel site on the GABAA receptor complex in a therapeutically relevant fashion and may be used to ameliorate CNS disorders amenable to modulation of the GABAA receptor complex.
    Type: Grant
    Filed: May 12, 2003
    Date of Patent: April 8, 2008
    Assignee: The Regents of the University of California
    Inventors: Timothy B. C. Johnstone, Derk J. Hogenkamp, Kelvin W. Gee
  • Substituted enaminones, their derivatives and uses thereof
    Publication number: 20080064748
    Abstract: The invention relates to substituted enaminones of Formula I and their derivatives and the discovery that these compounds modulate the effect of ?-aminobutyric acid (GABA) on the GABAA receptor complex in a therapeutically relevant fashion and may be used to ameliorate CNS disorders amenable to modulation of the GABAA receptor complex.
    Type: Application
    Filed: May 5, 2005
    Publication date: March 13, 2008
    Inventors: Derk J. Hogenkamp, Timothy B.C. Johnstone, Kelvin W. Gee
  • Aryl substituted pyrazoles, triazoles, and tetrazoles, and the use thereof
    Patent number: 7078426
    Abstract: This invention relates to compounds having the Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and R5-R8 are set in the specification. The invention also is directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
    Type: Grant
    Filed: March 22, 2001
    Date of Patent: July 18, 2006
    Assignee: Euro-Celtique S.A.
    Inventors: Derk J. Hogenkamp, Phong Nguyen, Ji Yang
  • Aryl substituted pyrazoles, triazoles and tetrazoles, and the use thereof
    Patent number: 6919363
    Abstract: This invention relates to compounds having the Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and R5-R8 are set in the specification. The invention also is directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
    Type: Grant
    Filed: June 9, 2003
    Date of Patent: July 19, 2005
    Assignee: Euro-Celtique S.A.
    Inventors: Derk J. Hogenkamp, Phong Nguyen, Ji Yang
  • Aryl substituted pyrimidines
    Patent number: 6867210
    Abstract: This invention relates aryl substituted pyridines, pyrimidines, pyrazines and triazines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein A1, A2, A3, R1-R4, X and Y are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
    Type: Grant
    Filed: March 12, 2001
    Date of Patent: March 15, 2005
    Assignee: Euro-Celtique S.A.
    Inventors: Derk J. Hogenkamp, Phong Nguyen, Bin Shao
  • Aryl substituted pyridines, pyrimidines, pyrazines and triazines and the use thereof
    Publication number: 20040192691
    Abstract: This invention relates aryl substituted pyridines, pyrimidines, pyrazines and triazines of Formula I: 1
    Type: Application
    Filed: December 19, 2003
    Publication date: September 30, 2004
    Applicant: Euro-Celtique S.A.
    Inventors: Derk J. Hogenkamp, Phong Nguyen, Bin Shao
  • Neuroactive steroids of the androstane and pregnane series
    Patent number: 6780853
    Abstract: The invention relates to 3&agr;-hydroxy, 17-(un)substituted derivatives of the androstane series and 3&agr;-hydroxy, 21-substituted derivatives of the pregnane series. These derivatives are capable of acting at a recently identified site on the GRC, thereby modulating brain excitability in a manner that will alleviate stress, anxiety, insomnia, mood disorders that are amenable to GRC-active agents (such as depression) and seizure activity. The steroid derivatives of this invention are those having the general structural Formula: wherein R, R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are farther defined herein and the dotted lines are single or double bonds. The structure includes androstanes, pregnanes (R4=methyl), 19-norandrostanes, and norpregnanes (R4=H).
    Type: Grant
    Filed: May 28, 1999
    Date of Patent: August 24, 2004
    Assignee: Euro-Celtique S.A.
    Inventors: Ravindra B. Upasani, David B. Fick, Derk J. Hogenkamp, Nancy C. Lan
  • Aryl substituted pyrazoles, triazoles and tetrazoles, and the use thereof
    Publication number: 20040002523
    Abstract: This invention relates to compounds having the Formula I: 1
    Type: Application
    Filed: June 9, 2003
    Publication date: January 1, 2004
    Applicant: Euro-Celtique S.A.
    Inventors: Derk J. Hogenkamp, Phong Nguyen, Ji Yang
  • Aryl substituted pyridines, pyrimidines, pyrazines and triazines and the use thereof
    Publication number: 20020040025
    Abstract: This invention relates aryl substituted pyridines, pyrimidines, pyrazines and triazines of Formula I: 1
    Type: Application
    Filed: March 12, 2001
    Publication date: April 4, 2002
    Inventors: Derk J. Hogenkamp, Phong Nguyen, Bin Shao
  • Aryl substituted pyrazoles, triazoles, and tetrazoles, and the use thereof
    Publication number: 20020006947
    Abstract: This invention relates to compounds having the Formula I: 1
    Type: Application
    Filed: March 22, 2001
    Publication date: January 17, 2002
    Inventors: Derk J. Hogenkamp, Phong Nguyen, Ji Yang
  • Aminopyridines and methods of using thereof
    Patent number: 6335354
    Abstract: This invention relates to aminopyridines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein R1-R8, X and m are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
    Type: Grant
    Filed: March 29, 2001
    Date of Patent: January 1, 2002
    Assignee: CoCensys Inc.
    Inventor: Derk J. Hogenkamp
  • Aminopyridines and methods of using thereof
    Publication number: 20010044428
    Abstract: This invention relates to aminopyridines of Formula I: 1
    Type: Application
    Filed: March 29, 2001
    Publication date: November 22, 2001
    Applicant: CoCensys, Inc.
    Inventor: Derk J. Hogenkamp
  • Neuroactive steroids of the androstane and pregnane series
    Patent number: 5925630
    Abstract: The invention relates to 3.alpha.-hydroxy, 17-(un)substituted derivatives of the androstane series and 3.alpha.-hydroxy, 21-substituted derivatives of the pregnane series. These derivatives are capable of acting at a recently identified site on the GRC, thereby modulating brain excitability in a manner that will alleviate stress, anxiety, insomnia, mood disorders that are amenable to GRC-active agents (such as depression) and seizure activity. The steroid derivatives of this invention are those having the general structural Formula: ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and R.sub.10 are further defined herein and the dotted lines are single or double bonds. The structure includes androstanes, pregnanes (R.sub.4 =methyl), 19-norandrostanes, and norpregnanes (R.sub.4 =H).
    Type: Grant
    Filed: June 6, 1996
    Date of Patent: July 20, 1999
    Assignee: CoCensys, Inc.
    Inventors: Ravindra B. Upasani, David B. Fick, Derk J. Hogenkamp, Nancy C. Lan
  • Process for synthesis of steroidal allylic tert. alcohols
    Patent number: 5449795
    Abstract: A method for the preparation of a steroidal allylic tertiary alcohol is disclosed which involves the deprotonation of a sulfoxide with a strong base which is capable of deprotonating the methine proton which is .alpha. to the sulfoxide, in an inert solvent to give the anion; reaction of the anion with a steroidal spiro-2'-oxirane to give a steroidal .gamma.-hydroxysulfoxide; and thermolysis in the presence of a base other than calcium carbonate to give the steroidal allylic tertiary alcohol.
    Type: Grant
    Filed: February 14, 1994
    Date of Patent: September 12, 1995
    Assignee: CoCensys, Inc.
    Inventor: Derk J. Hogenkamp