Abstract: An object/test material interaction microti iridic device comprising a sample inlet adapted to receive a fluid sample comprising a plurality of objects, an outlet adapted to output the fluid sample from the device, at least one internal surface defining a flow cavity within the device, wherein the flow cavity extends between and is connected to the sample inlet and the outlet for flow of the fluid sample through the flow cavity, the flow cavity comprises a test area to which at least one test material is attached and which is situated in the flow cavity for flow of the fluid sample over the test area, and the flow cavity has an aspect ratio which, when the flow cavity is substantially filled by the fluid sample, provides a substantially constant shear force between the test area and the fluid sample flowing over the test area. The invention further comprises a system incorporating the device, methods of use of the device and system, and methods of analyzing interactions.

Abstract: The invention relates to a method of screening a patient to identify and quantify risk of colorectal cancer, and thereby identify patients suitable for further invasive investigation such as a colonoscopy. The method employs auto-antibodies that are shown to correlate with colorectal cancer risk method and involves of assaying a biological sample from the individual for a combination of a plurality of biomarkers selected from SEQUENCE ID NO's: 1 to 12, where the combination of biomarkers is chosen such that detection of all biomarkers in the patient correlates to at least a 50% risk of the patient being positive for colorectal cancer. Detection of all of the combination of biomarkers indicates that the patient should undergo a colonoscopy. Kits for performing the method of the invention are also provided.

Abstract: An object/test material interaction microti iridic device comprising a sample inlet adapted to receive a fluid sample comprising a plurality of objects, an outlet adapted to output the fluid sample from the device, at least one internal surface defining a flow cavity within the device, wherein the flow cavity extends between and is connected to the sample inlet and the outlet for flow of the fluid sample through the flow cavity, the flow cavity comprises a test area to which at least one test material is attached and which is situated in the flow cavity for flow of the fluid sample over the test area, and the flow cavity has an aspect ratio which, when the flow cavity is substantially filled by the fluid sample, provides a substantially constant shear force between the test area and the fluid sample flowing over the test area. The invention further comprises a system incorporating the device, methods of use of the device and system, and methods of analysing interactions.

Abstract: Use of a metal complex having the formula: [M(L1)a(L2)b(L3)c]-Xd-Pepe wherein M is a metal selected from osmium, ruthenium, rhodium, rhenium or copper; L1, L2, L are bidentate or tridentate heterocyclic ligands containing O and/or N and may be the same or different; a, b, c are integers between 0 to 3 and may be the same or different and wherein the sum of a+b+c is 2 or 3; X is a functional group for directly or indirectly covalently binding to Pep wherein the functional group for directly covalently binding to Pep is selected from: amine, carboxylic acid, thiol or azide reactive functionalities; Pep is a peptide; d and e are integers between 1 and 3 and are the same and wherein the integers for d and e are equal to or less than the sum of a+b+c; and wherein there is optionally a linker between X and Pep for imaging of a cell or cell derived biological sample.

Abstract: The invention relates to a method of screening a patient to identify and quantify risk of colorectal cancer, and thereby identify patients suitable for further invasive investigation such as a colonoscopy. The method employs auto-antibodies that are shown to correlate with colorectal cancer risk method and involves of assaying a biological sample from the individual for a combination of a plurality of biomarkers selected from SEQUENCE ID NO's: 1 to 12, where the combination of biomarkers is chosen such that detection of all biomarkers in the patient correlates to at least a 50% risk of the patient being positive for colorectal cancer. Detection of all of the combination of biomarkers indicates that the patient should undergo a colonoscopy. Kits for performing the method of the invention are also provided.

Abstract: A method of generating a platelet reactivity profile of an individual comprises the steps of providing a platelet-containing biological sample from the individual, providing at least three platelet function modulators, each platelet function modulator being provided in at least three concentrations, and reacting an aliquot of the platelet containing sample with each concentration of each platelet function modulator in a separate reaction vessel. Platelet aggregation is then measured in each reaction vessel, and the platelet aggregation measurements are used to generate a dose response curve for each platelet function modulator, wherein the dose response curves obtained and/or one or more functions of the dose response curves obtained, comprise a platelet reactivity profile for the individual. Clinical applications of, and kits for carrying out, the methods of the invention are also described.