Abstract: Porous particles comprising an active ingredient and a coating exhibiting greater dissolution rate in aqueous media than in alcoholic media are disclosed. A process for the manufacture of the particles is also disclosed, as well as tamper-proof particles and solid dosage forms comprising the coated particles. The differential solubility characteristics of the particle coating allow the particles to be incorporated into abuse-deterrent medicaments.

Abstract: Processes for making magnesium-containing layered double hydroxides from a magnesium phosphate-containing mineral are disclosed, as well as a magnesium-containing layered double hydroxides and their uses.

Abstract: Surface-modified layered double hydroxides (LDHs) are disclosed, as well as processes by which they are made, and uses of the LDHs in composite materials. The surface-modified LDHs of the invention are more organophilic than their unmodified analogues, which allows the LDHs to be incorporated in a wide variety of materials, wherein the interesting functionality of LDHs may be exploited.

Abstract: A catalytic process for the deoxygenation of an organic substrate, such as a biomass or bio-oil, is described. The catalytic process is conducted in the presence of a gaseous mixture containing both hydrogen and nitrogen. The presence of nitrogen in the gaseous mixture gives rise inter-aliato increased catalytic activity and/or increased selectivity for aromatic reaction products.

Abstract: The present invention relates to a process for modifying a layered double hydroxide (LDH), the process comprising, a. providing a water-wet layered double hydroxide of formula: [Mz+1-xM?y+x]a+(Xn?)a/r.bH2O ??(1) wherein M and M? are metal cations, z=1 or 2; y=3 or 4, x is 0.1 to 1, preferably x<1, more preferably x=0.1-0.9, b is greater than 0 to 10, X is an anion, r is 1 to 3, n is the charge on the anion X and a is determined by x, y and z, preferably a=z(1-x)+xy-2; b. maintaining the layered double hydroxide water-wet, and c. contacting the water-wet layered double hydroxide with at least one solvent, the solvent being miscible with water and preferably having a solvent polarity (P?) in the range 3.8 to 9, as well as to a layered double hydroxide prepared according to that process.

Abstract: Unsymmetrical metallocene compounds based on cyclopentadienyl ligands are disclosed, as well as catalytic compositions comprising the compounds supported on solid support materials. The compounds and compositions are useful as catalysts in the polymerisation of olefins. In particular, the compounds and compositions are useful catalysts in the preparation of low molecular weight polyethylene (e.g. polyethylene wax) and copolymers formed from the polymerisation of ethylene and other ?-olefins.

Abstract: A process for the preparation of a coated substrate is described, in which a substrate is coated with a coating mixture containing a polymer and an amino acid-modified layered double hydroxide. The process of the invention is markedly simpler than conventional techniques for affording coated substrates having reduced permeability to degradative gases. The coated substrates obtainable by the process are particularly useful in packaging applications, notably in the food industry.

Abstract: Catalytic compositions comprising permethylpentalene based metallocene complexes supported on solid methylaluminoxane are disclosed. The compositions are effective catalysts/initiators in the polymerisation of olefins. Also disclosed are uses of the compositions in olefin polymerisation.

Abstract: Porous particles comprising an active ingredient and a coating exhibiting greater dissolution rate in aqueous media than in alcoholic media are disclosed. A process for the manufacture of the particles is also disclosed, as well as tamper-proof particles and solid dosage forms comprising the coated particles. The differential solubility characteristics of the particle coating allow the particles to be incorporated into abuse-deterrent medicaments.

Abstract: Solid support materials are described for use as supports for olefin polymerisation catalysts. Also described is a process for the preparation of the solid support materials and the use of the solid support materials as supports in olefin polymerisation reactions.

Abstract: Modified solid polymethylaluminoxanes are described for use as support materials for olefin polymerisation catalysts. The modified solid polymethylaluminoxanes have higher specific surface areas than their unmodified analogues. Also described is a process for the preparation of the modified solid polymethylaluminoxanes and the use of the modified solid polymethylaluminoxanes as support materials in olefin polymerisation reactions.

Abstract: A method of making silica-layered double hydroxide microspheres having the formula I: (i) wherein, Mz+ and M?y+ are two different charged metal cations; z=1 or 2; y=3 or 4; 0<x<0.9; b is 0 to 10; c is 0 to 10; P>0, q>0, Xn? is an anion; with n>0 a=z(1?x)+xy?2; and the AMO-solvent is an 100% aqueous miscible organic solvent; comprises the steps: (a) contacting silica microspheres and a metal ion containing solution containing metal ions Mz+ and M?y+ in the presence of a base and an anion solution; (b) collecting the product; and (c) optionally treating the product with AMO-solvent and recovering the solvent treated material to obtain the silica-layered double hydroxide microspheres. Preferably, M in the formula I is Li, Mg, Ni or Ca. Preferably, M? in formula I is Al. The invention further provides silica-layered double hydroxide microspheres having the formula I. The silica-layered double hydroxide microspheres may be used as catalysts and/or catalyst supports.

Abstract: New layered double hydroxide materials useful as intermediates in the formation of catalysts are described, as well as methods of preparing the layered double hydroxides. Also described are catalysts suitable for catalysing the hydrogenation of CO2 to methanol, as well as methods for preparing the catalysts. The LDH-derived catalysts of the invention are active in the hydrogenation of CO2 to methanol, and show improved activity with respect to Cu/ZnO catalysts derived from copper-zinc hydroxycarbonate precursors.

Abstract: Solid-phase supported materials are described for use in supporting metallocene catalytic compounds. The supported metallocene catalytic compositions are efficient olefin polymerisation catalysts, which show notably higher catalytic activity compared to catalytic compounds employing conventional support materials.

Abstract: A process for the preparation of a film is described, in which a substrate is coated with a coating mixture containing a water-soluble polymer and a layered double hydroxide. The process of the invention is markedly simpler that conventional techniques for affording films having reduced permeability to degradative gases. The films obtainable by the process are particularly useful in packaging applications, notably in the food industry.

Abstract: Bimetallic catalytic compounds and compositions comprising permethylpentalene ligands, as well as their methods of preparation, are described. The catalytic compounds and compositions are promising catalysts in olefin (e.g. ethylene) polymerisation reactions.

Abstract: Surface-modified layered double hydroxides (LDHs) are disclosed, as well as processes by which they are made, and uses of the LDHs in composite materials. The surface-modified LDHs of the invention are more organophilic than their unmodified analogues, which allows the LDHs to be incorporated in a wide variety of materials, wherein the interesting functionality of LDHs may be exploited.

Abstract: The present invention provides a process for the preparation of a multimodal polyethylene, said multimodal polyethylene preferably having a bimodal or trimodal M.W. distribution, comprising: (i) polymerizing ethylene and optionally an ?-olefin comonomer in a first polymerization stage to produce a first ethylene polymer; and (ii) polymerizing ethylene and optionally an ?-olefin comonomer, in the presence of said first ethylene polymer, in a second polymerization stage, wherein said first and second polymerization stages are carried out in the presence of an unsupported metallocene catalyst, which is a complex of a group 4-10 metal having at least two ligands, wherein at least one of the ligands is persubstituted and comprises a delocalized pi system of electrons, each polymerization stage produces at least 5% wt of said multimodal polyethylene, and said multimodal polyethylene has a multimodal M.W. distribution, a M.W. of at least 50,000 g/mol and a bulk density of at least 250 g/dm3.

Abstract: Layered double hydroxides (LDHs) are disclosed, as well as methods by which they may be manufactured. The LDHs are subjected to a solvent treatment step during manufacture, which confers high surface area and pore volume properties to the LDHs. The particular solvents used in the preparation of the LDHs renders allows for an overall more efficient and environmentally-friendly manufacturing process.

Abstract: Catalytic compositions comprising constrained geometry compounds associated with solid polymethylaluminoxane are disclosed.