Patents by Inventor Derrick E. Rancourt

Derrick E. Rancourt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Attenuated reoviruses for selection of cell populations
    Patent number: 10369171
    Abstract: The present invention relates to methods for killing neoplastic cells, such as ras-activated cancerous cells, in vitro. In particular embodiments, an attenuated reovirus (e.g., a reovirus lacking a wild-type S1 gene) may be administered to a mixed cellular composition comprising cancerous cells and stem cells such as adult stem cells and/or hematopoietic stem cells; in these embodiments, the attenuated reovirus may result in killing of the cancerous cells with little or no damage to the healthy stem cells.
    Type: Grant
    Filed: March 12, 2008
    Date of Patent: August 6, 2019
    Assignee: VIROCURE, INC.
    Inventors: Manbok Kim, Derrick E. Rancourt, Nicole Zur Nieden, Randal N. Johnston
  • Expansion of Embryonic Stem Cells
    Publication number: 20110263016
    Abstract: The present invention addresses the problem of expanding human embryonic stem cell (hESC) and induced pluripotent stem cell (iPSC) populations to clinically relevant numbers while maintaining pluripotency. In particular, the use of macrolide antibiotics and inhibitors of Rho and Rho-associated kinases is described.
    Type: Application
    Filed: September 25, 2009
    Publication date: October 27, 2011
    Inventors: Derrick E. Rancourt, Guoliang Meng, Shiying Lui, Xiangyun Li, Roman Krawetz, Jaymi Cormier
  • Attenuated reoviruses for selection of cell populations
    Publication number: 20090104162
    Abstract: The present invention relates to methods for killing neoplastic cells, such as ras-activated cancerous cells, in vitro. In particular embodiments, an attenuated reovirus (e.g., a reovirus lacking a wild-type S1 gene) may be administered to a mixed cellular composition comprising cancerous cells and stem cells such as adult stem cells and/or hematopoietic stem cells; in these embodiments, the attenuated reovirus may result in killing of the cancerous cells with little or no damage to the healthy stem cells.
    Type: Application
    Filed: March 12, 2008
    Publication date: April 23, 2009
    Inventors: Manbok Kim, Derrick E. Rancourt, Nicole Zur Nieden, Randal N. Johnston
  • Implantation serine proteinases
    Publication number: 20030054993
    Abstract: This invention provides two novel serine proteinases that are important for female fertility, particularly in the process of hatching and implantation. These proteinases, as well as the nucleic acids, fragments, analogs, and/or inhibitors thereof, can be used to modulate hatching, implantation and female fertility in general.
    Type: Application
    Filed: April 8, 2002
    Publication date: March 20, 2003
    Inventors: Derrick E. Rancourt, Susan L. Rancourt, Colleen M. O'Sullivan
  • Bacteriophage vectors generated by bacteriophage/plasmid recombination
    Publication number: 20020090714
    Abstract: The present invention relates to methods for the generation of lambda (&lgr;) or P1 bacteriophage vectors useful in targeted mutagenesis of eukaryotic cells and the expression of genes and proteins, methods for the identification of a &lgr; or P1 bacteriophage vector having a desired nucleic acid from an assortment or library of bacteriophage each having a different nucleic acid insert and the use of such vectors in gene targeting and the expression of genes and protein.
    Type: Application
    Filed: March 23, 2001
    Publication date: July 11, 2002
    Inventors: Derrick E. Rancourt, Teruhisa Tsuzuki
  • Bacteriophage vectors generated by bacteriophage/plasmid recombination
    Patent number: 6335185
    Abstract: The present invention relates to methods for the generation of lambda (&lgr;) or P1 bacteriophage vectors useful in targeted mutagenesis of eukaryotic cells and the expression of genes and proteins, methods for the identification of a &lgr; or P1 bacteriophage vector having a desired nucleic acid from an assortment or library of bacteriophage each having a different nucleic acid insert and the use of such vectors in gene targeting and the expression of genes and protein.
    Type: Grant
    Filed: February 2, 1999
    Date of Patent: January 1, 2002
    Assignee: University Technologies International Inc.
    Inventors: Derrick E. Rancourt, Teruhisa Tsuzuki