Patents by Inventor Derrick Rossi

Derrick Rossi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUSTAINED POLYPEPTIDE EXPRESSION FROM SYNTHETIC, MODIFIED RNAS AND USES THEREOF
    Publication number: 20220162565
    Abstract: Described herein are synthetic, modified RNAs for changing the phenotype of a cell, such as expressing a polypeptide or altering the developmental potential. Accordingly, provided herein are compositions, methods, and kits comprising synthetic, modified RNAs for changing the phenotype of a cell or cells. These methods, compositions, and kits comprising synthetic, modified RNAs can be used either to express a desired protein in a cell or tissue, or to change the differentiated phenotype of a cell to that of another, desired cell type.
    Type: Application
    Filed: October 28, 2021
    Publication date: May 26, 2022
    Applicant: 55 Shattuck Street
    Inventors: Derrick ROSSI, Luigi WARREN
  • Isolated mammalian somatic cells containing modified RNA encoding OCT4, SOX2, and KLF4
    Patent number: 11186829
    Abstract: Described herein are synthetic, modified RNAs for changing the phenotype of a cell, such as expressing a polypeptide or altering the developmental potential. Accordingly, provided herein are compositions, methods, and kits comprising synthetic, modified RNAs for changing the phenotype of a cell or cells. These methods, compositions, and kits comprising synthetic, modified RNAs can be used either to express a desired protein in a cell or tissue, or to change the differentiated phenotype of a cell to that of another, desired cell type.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: November 30, 2021
    Assignee: Children's Medical Center Corporation
    Inventors: Derrick Rossi, Luigi Warren
  • SUSTAINED POLYPEPTIDE EXPRESSION FROM SYNTHETIC, MODIFIED RNAS AND USES THEREOF
    Publication number: 20190382729
    Abstract: Described herein are synthetic, modified RNAs for changing the phenotype of a cell, such as expressing a polypeptide or altering the developmental potential. Accordingly, provided herein are compositions, methods, and kits comprising synthetic, modified RNAs for changing the phenotype of a cell or cells. These methods, compositions, and kits comprising synthetic, modified RNAs can be used either to express a desired protein in a cell or tissue, or to change the differentiated phenotype of a cell to that of another, desired cell type.
    Type: Application
    Filed: May 28, 2019
    Publication date: December 19, 2019
    Applicant: Children's Medical Center Corporation
    Inventors: Derrick Rossi, Luigi Warren
  • Sustained polypeptide expression from synthetic, modified RNAs and uses thereof
    Patent number: 10344265
    Abstract: Described herein are synthetic, modified RNAs for changing the phenotype of a cell, such as expressing a polypeptide or altering the developmental potential. Accordingly, provided herein are compositions, methods, and kits comprising synthetic, modified RNAs for changing the phenotype of a cell or cells. These methods, compositions, and kits comprising synthetic, modified RNAs can be used either to express a desired protein in a cell or tissue, or to change the differentiated phenotype of a cell to that of another, desired cell type.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: July 9, 2019
    Assignee: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Derrick Rossi, Luigi Warren
  • SUSTAINED POLYPEPTIDE EXPRESSION FROM SYNTHETIC, MODIFIED RNAS AND USES THEREOF
    Publication number: 20180216078
    Abstract: Described herein are synthetic, modified RNAs for changing the phenotype of a cell, such as expressing a polypeptide or altering the developmental potential. Accordingly, provided herein are compositions, methods, and kits comprising synthetic, modified RNAs for changing the phenotype of a cell or cells. These methods, compositions, and kits comprising synthetic, modified RNAs can be used either to express a desired protein in a cell or tissue, or to change the differentiated phenotype of a cell to that of another, desired cell type.
    Type: Application
    Filed: August 31, 2017
    Publication date: August 2, 2018
    Applicant: Children's Medical Center Corporation
    Inventors: Derrick Rossi, Luigi Warren
  • Induced pluripotent stem cells with synthetic modified RNAs
    Patent number: 9803177
    Abstract: Described herein are synthetic, modified RNAs for changing the phenotype of a cell, such as expressing a polypeptide or altering the developmental potential. Accordingly, provided herein are compositions, methods, and kits comprising synthetic, modified RNAs for changing the phenotype of a cell or cells. These methods, compositions, and kits comprising synthetic, modified RNAs can be used either to express a desired protein in a cell or tissue, or to change the differentiated phenotype of a cell to that of another, desired cell type.
    Type: Grant
    Filed: June 23, 2014
    Date of Patent: October 31, 2017
    Assignee: Children's Medical Center Corporation
    Inventors: Derrick Rossi, Luigi Warren
  • COMPOSITIONS AND METHODS FOR REPROGRAMMING HEMATOPOIETIC STEM CELL LINEAGES
    Publication number: 20160032317
    Abstract: Provided herein are compositions, methods, and kits for hematopoietic stem cell induction or for reprogramming cells to the multipotent state of hematopoietic stem cells. In some embodiments, the compositions comprise at least one HSC inducing factor. Such compositions, methods and kits can be used for inducing hematopoietic stem cells in vitro, ex vivo, or in vivo, as described herein, and these induced hematopoietic stem cells can be used in regenerative medicine applications and therapies.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 4, 2016
    Applicant: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Derrick Rossi, Jonah Riddell, Roi Gazit
  • Kits comprising linear DNAs for sustained polypeptide expression using synthetic, modified RNAs
    Patent number: 8883506
    Abstract: Described herein are synthetic, modified RNAs for changing the phenotype of a cell, such as expressing a polypeptide or altering the developmental potential. Accordingly, provided herein are compositions, methods, and kits comprising synthetic, modified RNAs for changing the phenotype of a cell or cells. These methods, compositions, and kits comprising synthetic, modified RNAs can be used either to express a desired protein in a cell or tissue, or to change the differentiated phenotype of a cell to that of another, desired cell type.
    Type: Grant
    Filed: August 21, 2012
    Date of Patent: November 11, 2014
    Assignee: Children's Medical Center Corporation
    Inventors: Derrick Rossi, Luigi Warren
  • SUSTAINED POLYPEPTIDE EXPRESSION FROM SYNTHETIC, MODIFIED RNAS AND USES THEREOF
    Publication number: 20140308746
    Abstract: Described herein are synthetic, modified RNAs for changing the phenotype of a cell, such as expressing a polypeptide or altering the developmental potential. Accordingly, provided herein are compositions, methods, and kits comprising synthetic, modified RNAs for changing the phenotype of a cell or cells. These methods, compositions, and kits comprising synthetic, modified RNAs can be used either to express a desired protein in a cell or tissue, or to change the differentiated phenotype of a cell to that of another, desired cell type.
    Type: Application
    Filed: June 23, 2014
    Publication date: October 16, 2014
    Inventors: Derrick Rossi, Luigi Warren
  • Compositions, kits, and methods for making induced pluripotent stem cells using synthetic modified RNAs
    Patent number: 8802438
    Abstract: Described herein are synthetic, modified RNAs for changing the phenotype of a cell, such as expressing a polypeptide or altering the developmental potential. Accordingly, provided herein are compositions, methods, and kits comprising synthetic, modified RNAs for changing the phenotype of a cell or cells. These methods, compositions, and kits comprising synthetic, modified RNAs can be used either to express a desired protein in a cell or tissue, or to change the differentiated phenotype of a cell to that of another, desired cell type.
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: August 12, 2014
    Assignee: Children's Medical Center Corporation
    Inventors: Derrick Rossi, Luigi Warren
  • Kit for making induced pluripotent stem cells using modified RNAs
    Patent number: 8716465
    Abstract: Described herein are synthetic, modified RNAs for changing the phenotype of a cell, such as expressing a polypeptide or altering the developmental potential. Accordingly, provided herein are compositions, methods, and kits comprising synthetic, modified RNAs for changing the phenotype of a cell or cells. These methods, compositions, and kits comprising synthetic, modified RNAs can be used either to express a desired protein in a cell or tissue, or to change the differentiated phenotype of a cell to that of another, desired cell type.
    Type: Grant
    Filed: August 21, 2012
    Date of Patent: May 6, 2014
    Assignee: Children's Medical Center Corporation
    Inventors: Derrick Rossi, Luigi Warren
  • SUSTAINED POLYPEPTIDE EXPRESSION FROM SYNTHETIC, MODIFIED RNAS AND USES THEREOF
    Publication number: 20120322865
    Abstract: Described herein are synthetic, modified RNAs for changing the phenotype of a cell, such as expressing a polypeptide or altering the developmental potential. Accordingly, provided herein are compositions, methods, and kits comprising synthetic, modified RNAs for changing the phenotype of a cell or cells. These methods, compositions, and kits comprising synthetic, modified RNAs can be used either to express a desired protein in a cell or tissue, or to change the differentiated phenotype of a cell to that of another, desired cell type.
    Type: Application
    Filed: August 21, 2012
    Publication date: December 20, 2012
    Applicant: IMMUNE DISEASE INSTITUTE, INC.
    Inventors: Derrick Rossi, Luigi Warren
  • SUSTAINED POLYPEPTIDE EXPRESSION FROM SYNTHETIC, MODIFIED RNAS AND USES THEREOF
    Publication number: 20120322864
    Abstract: Described herein are synthetic, modified RNAs for changing the phenotype of a cell, such as expressing a polypeptide or altering the developmental potential. Accordingly, provided herein are compositions, methods, and kits comprising synthetic, modified RNAs for changing the phenotype of a cell or cells. These methods, compositions, and kits comprising synthetic, modified RNAs can be used either to express a desired protein in a cell or tissue, or to change the differentiated phenotype of a cell to that of another, desired cell type.
    Type: Application
    Filed: August 21, 2012
    Publication date: December 20, 2012
    Applicant: IMMUNE DISEASE INSTITUTE, INC.
    Inventors: Derrick Rossi, Luigi Warren
  • SUSTAINED POLYPEPTIDE EXPRESSION FROM SYNTHETIC, MODIFIED RNAS AND USES THEREOF
    Publication number: 20120046346
    Abstract: Described herein are synthetic, modified RNAs for changing the phenotype of a cell, such as expressing a polypeptide or altering the developmental potential. Accordingly, provided herein are compositions, methods, and kits comprising synthetic, modified RNAs for changing the phenotype of a cell or cells. These methods, compositions, and kits comprising synthetic, modified RNAs can be used either to express a desired protein in a cell or tissue, or to change the differentiated phenotype of a cell to that of another, desired cell type.
    Type: Application
    Filed: April 15, 2011
    Publication date: February 23, 2012
    Applicant: IMMUNE DISEASE INSTITUTE, INC.
    Inventors: Derrick Rossi, Luigi Warren