Abstract: This patent proves that enucleated red blood cells are the product of biological evolution and disabled red blood cells due to functional defects. Platelets are the nuclei removed during the enucleation of nucleated red blood cells. They are useful components for blood coagulation and hemostasis, but not essential components. Nucleated erythrocytes are fully functional erythrocytes. The preparation of nucleated red blood cell blood, especially the universal blood without blood type, not only has all the functions of red blood cells, but also can be replicated in the blood, improving the physiological performance of blood and reducing the cost and time of artificial blood.