Patents by Inventor Deryk T. Loo

Deryk T. Loo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies reactive with B7-H3 and uses thereof
    Patent number: 9441049
    Abstract: The present invention relates to antibodies that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.
    Type: Grant
    Filed: July 15, 2014
    Date of Patent: September 13, 2016
    Assignee: MacroGenics, Inc.
    Inventors: Leslie S. Johnson, Ling Huang, Paul A. Moore, Deryk T. Loo, Francine Z. Chen
  • Antibodies reactive with B7-H3, immunologically active fragments thereof and uses thereof
    Patent number: 9150656
    Abstract: The present invention relates to antibodies and their fragments that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies and their immunoreactive fragments that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.
    Type: Grant
    Filed: March 1, 2011
    Date of Patent: October 6, 2015
    Assignee: MacroGenics, Inc.
    Inventors: Leslie S. Johnson, Paul A. Moore, Ling Huang, Deryk T. Loo, Francine Zhifen Chen
  • Antibodies Reactive with B7-H3, Immunologically Active Fragments Thereof and Uses Thereof
    Publication number: 20150274838
    Abstract: The present invention relates to antibodies and their fragments that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies and their immunoreactive fragments that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.
    Type: Application
    Filed: June 1, 2015
    Publication date: October 1, 2015
    Applicant: MACROGENICS, INC.
    Inventors: Leslie S. Johnson, Paul A. Moore, Ling Huang, Deryk T. Loo, Francine Z. Chen
  • Antibodies Reactive with B7-H3, Immunologically Active Fragments Thereof and Uses Thereof
    Publication number: 20150259434
    Abstract: The present invention relates to antibodies and their fragments that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies and their immunoreactive fragments that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.
    Type: Application
    Filed: June 1, 2015
    Publication date: September 17, 2015
    Applicant: MACROGENICS, INC.
    Inventors: Leslie S. Johnson, Paul A. Moore, Ling Huang, Deryk T. Loo, Francine Z. Chen
  • Antibodies Reactive with B7-H3 and Uses Thereof
    Publication number: 20140328750
    Abstract: The present invention relates to antibodies that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.
    Type: Application
    Filed: July 15, 2014
    Publication date: November 6, 2014
    Applicant: MACROGENICS, INC.
    Inventors: Leslie S. Johnson, Ling Huang, Paul A. Moore, Deryk T. Loo, Francine Z. Chen
  • Antibodies reactive with B7-H3 and uses thereof
    Patent number: 8802091
    Abstract: The present invention relates to antibodies that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: August 12, 2014
    Assignee: MacroGenics, Inc.
    Inventors: Leslie S. Johnson, Ling Huang, Paul A. Moore, Deryk T. Loo, Francine Z. Chen
  • Antibodies Reactive with B7-H3, Immunologically Active Fragments Thereof and Uses Thereof
    Publication number: 20130149236
    Abstract: The present invention relates to antibodies and their fragments that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies and their immunoreactive fragments that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.
    Type: Application
    Filed: March 1, 2011
    Publication date: June 13, 2013
    Applicant: MACROGENICS, INC.
    Inventors: Leslie S. Johnson, Paul A. Moore, Ling Huang, Deryk T. Loo, Francine Zhifen Chen
  • KID3 and KID3 antibodies that bind thereto
    Patent number: 8440197
    Abstract: The invention provides the identification and characterization of disease and cancer-associated epitope, KID3. The invention also provides a family of monoclonal antibodies that bind to KID3, methods of diagnosing and treating various human cancers and diseases that express KID3.
    Type: Grant
    Filed: July 7, 2010
    Date of Patent: May 14, 2013
    Assignee: MacroGenics, Inc.
    Inventors: Tony W. Liang, Deryk T. Loo, Xiaolin Xu
  • ADAM-9 modulators
    Patent number: 8361475
    Abstract: The invention provides the identification and characterization of a disease and cancer-associated antigen, KID24. The invention also provides modulators of KID24, including a family of monoclonal antibodies that bind to antigen KID24, and methods of diagnosing and treating various human cancers and diseases with KID24.
    Type: Grant
    Filed: January 14, 2010
    Date of Patent: January 29, 2013
    Assignee: MacroGenics West, Inc.
    Inventors: Jennie P. Mather, Deryk T. Loo
  • Antibodies Reactive with B7-H3 and Uses Thereof
    Publication number: 20120294796
    Abstract: The present invention relates to antibodies that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.
    Type: Application
    Filed: May 4, 2012
    Publication date: November 22, 2012
    Applicant: MACROGENICS, INC.
    Inventors: Leslie S. Johnson, Ling Huang, Paul A. Moore, Deryk T. Loo, Francine Z. Chen
  • KID31 and antibodies that bind thereto
    Patent number: 8313916
    Abstract: The invention provides the identification and characterization of a disease and cancer-associated antigen, KID31. The invention also provides modulators of KID31, including a family of monoclonal antibodies that bind to antigen KID31, and methods of diagnosing and treating various human cancers and diseases with KID31.
    Type: Grant
    Filed: February 13, 2010
    Date of Patent: November 20, 2012
    Assignee: MacroGenics West, Inc.
    Inventors: Jennie P. Mather, Deryk T. Loo
  • KID3 and KID3 Antibodies That Bind Thereto
    Publication number: 20100322851
    Abstract: The invention provides the identification and characterization of disease and cancer-associated epitope, KID3. The invention also provides a family of monoclonal antibodies that bind to KID3, methods of diagnosing and treating various human cancers and diseases that express KID3.
    Type: Application
    Filed: July 7, 2010
    Publication date: December 23, 2010
    Applicant: MacroGenics, Inc.
    Inventors: Tony W. Liang, Deryk T. Loo, Xiaolin Xu
  • KID3 and KID3 antibodies that bind thereto
    Patent number: 7790855
    Abstract: The invention provides the identification and characterization of disease and cancer-associated epitope, KID3. The invention also provides a family of monoclonal antibodies that bind to KID3, methods of diagnosing and treating various human cancers and diseases that express KID3.
    Type: Grant
    Filed: September 17, 2004
    Date of Patent: September 7, 2010
    Assignee: MacroGenics, Inc.
    Inventors: Tony W. Liang, Deryk T. Loo, Xiaolin Xu
  • KID31 And Antibodies That Bind Thereto
    Publication number: 20100150921
    Abstract: The invention provides the identification and characterization of a disease and cancer-associated antigen, KID31. The invention also provides modulators of KID31, including a family of monoclonal antibodies that bind to antigen KID31, and methods of diagnosing and treating various human cancers and diseases with KID31.
    Type: Application
    Filed: February 13, 2010
    Publication date: June 17, 2010
    Applicant: RAVEN BIOTECHNOLOGIES, INC.
    Inventors: Jennie P. Mather, Deryk T. Loo
  • ADAM-9 Modulators
    Publication number: 20100111951
    Abstract: The invention provides the identification and characterization of a disease and cancer-associated antigen, KID24. The invention also provides modulators of KID24, including a family of monoclonal antibodies that bind to antigen KID24, and methods of diagnosing and treating various human cancers and diseases with KID24.
    Type: Application
    Filed: January 14, 2010
    Publication date: May 6, 2010
    Applicant: RAVEN BIOTECHNOLOGIES, INC.
    Inventors: Jennie P. Mather, Deryk T. Loo
  • KID31 and antibodies that bind thereto
    Patent number: 7687242
    Abstract: The invention provides the identification and characterization of disease and cancer-associated antigen, KID31. The invention also provides a family of monoclonal antibodies that bind to antigen KID31, methods of diagnosing and treating various human cancers and diseases that express KID31.
    Type: Grant
    Filed: January 12, 2006
    Date of Patent: March 30, 2010
    Assignee: Raven Biotechnologies, Inc.
    Inventors: Jennie P. Mather, Deryk T. Loo
  • ADAM-9 modulators
    Patent number: 7674619
    Abstract: The invention provides the identification and characterization of a disease and cancer-associated antigen, KID24. The invention also provides modulators of KID24, including a family of monoclonal antibodies that bind to antigen KID24, and methods of diagnosing and treating various human cancers and diseases associated with KID24.
    Type: Grant
    Filed: February 2, 2006
    Date of Patent: March 9, 2010
    Inventors: Jennie P. Mather, Deryk T. Loo
  • ALCAM and ALCAM modulators
    Publication number: 20040048319
    Abstract: Provided herein is disclosure about the discovery that the known antigen, ALCAM, is present on a variety of human cancers other than metastasizing malignant melanoma. Also disclosed herein are methods of diagnosing and treating cancers that express ALCAM by using antibodies directed against ALCAM. This invention also discloses compositions and methods for the modulation of ALCAM-mediated neovascularization.
    Type: Application
    Filed: May 2, 2003
    Publication date: March 11, 2004
    Inventors: Jennie P. Mather, Ronghao Li, Mary C. Tsao, Deryk T. Loo