Abstract: The present invention disclosure also relates to a pharmaceutical composition that ccomprises the compound as an active ingredient.

Abstract: The present invention relates to a hydroxamate compound represented by formula (I), a preparation method therefor, and an application thereof. The present invention also relates to a pharmaceutical composition comprising the compound as an active ingredient and a use of the compound or pharmaceutical composition for treating and/or preventing related diseases mediated by TYK2.

Abstract: A biphenyl compound represented by formula (I), a preparation method therefor and an application thereof. The present invention also relates to a pharmaceutical composition that comprises the compound as an active ingredient. The compound is a novel small molecule immunomodulator having excellent oral absorption features and can be used for treating and/or preventing various immunity-related diseases.

Abstract: A biphenyl compound represented by formula (I), a preparation method therefor and an application thereof. The present invention also relates to a pharmaceutical composition that comprises the compound as an active ingredient. The compound is a novel small molecule immunomodulator having excellent oral absorption features and can be used for treating and/or preventing various immunity-related diseases.

Abstract: The present invention relates to the field of medicines, and in particular relates to use of chiauranib in combination with an immune checkpoint inhibitor in antitumor therapy. Use of a combination of chiauranib or a derivative thereof and the immune checkpoint inhibitor in the preparation of a medicine for treating a tumor, a pharmaceutical composition and a kit comprising the combination, and a method for treating a tumor by administering a therapeutically effective amount of the pharmaceutical composition or the kit to a tumor patient in need thereof. The combination has a synergistic effect and is suitable for treating a cancer.

Abstract: Use of a component (i) represented by a general formula (I) or a pharmaceutically acceptable salt or isomer of the compound, in combination with a component (ii) of a SGLT2 inhibitor in the manufacture of a medicament for the prevention and/or treatment of diabetes mellitus and/or a diabetic complication, as well as a pharmaceutical composition comprising the component (i) and the component (ii).

Abstract: Disclosed are a composition containing an aromatic heterocyclic compound in an amorphous form, and a preparation method therefore and a use thereof. Specifically, disclosed is a composition containing a compound of Formula (1) and a carrier, wherein the compound of formula (1) is in an amorphous form. The composition shows valuable properties in terms of in vivo absorption and bioavailability, and has the advantages of rapid absorption and high bioavailability, etc.

Abstract: A chidamide pharmaceutical composition, a preparation method therefor and an application thereof. The pharmaceutical composition comprises chidamide and a pharmaceutically acceptable enteric excipient that severe as a carrier. In the pharmaceutical composition, chidamide is used as a guest molecule, and the pharmaceutically acceptable enteric excipient is used as a carrier molecule. Oral pharmacokinetic testing on animal proves that the bioavailability of the composition comprising chidamide and the pharmaceutically acceptable enteric excipient is greatly improved, while adverse reactions caused by the drug in the gastrointestinal tract are reduced; in addition, the dosage may be reduced while maintaining the curative effect, thus having more important clinical significance than commercially available chidamide tablets.

Abstract: Use of a compound in preventing or treating a graft versus host disease (GVHD), especially use of the compound of formula (I) or a pharmaceutically acceptable salt thereof in preparing a drug for preventing or treating GVHD.

Abstract: Disclosed are a method for treating small cell lung cancer by using chiauranib and the use of chiauranib in the preparation of a drug for treating small cell lung cancer.

Abstract: The present invention provides use of KDM5A gene and/or ATRX gene as biomarkers in evaluating the efficacy of Chiauranib or guiding the administration of Chiauranib, and use of Chiauranib for the manufacture of a drug for treating small cell lung cancer patients with gene mutations in KDM5A gene or ATRX gene.

Abstract: Provided is an application of chiglitazar and related compounds thereof; in vitro models and animal models illustrate that chiglitazar and related compounds thereof inhibit fibroblast activation, matrix production, monocyte activation and chemotactic activity in vitro, and reduce inflammatory activity and tissue fibrosis area in animal models of liver fibrosis. Compared with known similar compounds, sodium chiglitazar shows more significant and different activity characteristics, and has better application potential for treating fibrotic disease.

Abstract: Use of a combination of a histone deacetylase inhibitor and a protein kinase inhibitor in the preparation of a medicament for the treatment or prevention of tumors, a pharmaceutical composition comprising a histone deacetylase inhibitor and a protein kinase inhibitor as active ingredients, and a method for treating or preventing cancers by combining a histone deacetylase inhibitor and a protein kinase inhibitor.

Abstract: The present invention relates to a formamide compound, a preparation method therefor and an application thereof. The structure of the compound is shown in formula (I), and the definition of each variable in the formula is as provided in the description. The compound is capable of inhibiting the activity of ASK1 kinase. The compound of the present invention may be used in the treatment/prevention of diseases associated with ASK1 kinase, such as inflammatory diseases, metabolic diseases, autoimmune diseases, cardiovascular diseases, neurodegenerative diseases, cancers and other diseases.

Abstract: The present invention discloses an enantiomeric compound (?)-2-[(2-(4-fluorobenzoyl)phenyl)amine]-3-[(4-(2-carbazole-ethoxy)phenyl)]propionic acid as represented by formula (I), or a pharmaceutical salt thereof, and a manufacturing method of the compound and application of same. The enantiomeric compound demonstrates relatively better activation of RXR/PPAR-, RXR/PPAR- and RXR/PPAR-heterodimer expression and sugar reduction in a db/db mouse model compared to a (+)-enantiomer.

Abstract: An application of a compound having general formula (I) as JAK3 and/or JAK1 kinase and a preparation method for the compound.

Abstract: A power conversion apparatus including a power converter, a first output port, a second output port, a load detection circuit and an output selection circuit is provided. The power converter generates a first and a second output voltages having different voltage specification. The first and the second output ports respectively provide the received output voltages to a back end. The load detection circuit is coupled with the power converter and the second output port and detects a load requirement of a load connected to the second output port to generate a load detection signal. The power converter generates a first switch control signal according to the load detection signal to control the output selection circuit, such that the output selection circuit provides one of the first and the second output voltages in response to the first switch control signal.

Abstract: An application of a compound having general formula (I) as JAK3 and/or JAK1 kinase and a preparation method for the compound.

Abstract: A power conversion apparatus including a power converter, a first output port, a second output port, a load detection circuit and an output selection circuit is provided. The power converter generates a first and a second output voltages having different voltage specification. The first and the second output ports respectively provide the received output voltages to a back end. The load detection circuit is coupled with the power converter and the second output port and detects a load requirement of a load connected to the second output port to generate a load detection signal. The power converter generates a first switch control signal according to the load detection signal to control the output selection circuit, such that the output selection circuit provides one of the first and the second output voltages in response to the first switch control signal.