Patents by Inventor Desmond C. Adler
Desmond C. Adler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230346601Abstract: A system for treating an eye includes a laser light source providing photoactivating light. The system includes a scanning system to receive the photoactivating light as a laser beam and to move the laser beam over a cornea treated with a cross-linking agent. The system includes a controller that provides control signal(s) to programmatically control the laser light source and the scanning system. The control signal(s) cause the laser beam to visit region(s) of the cornea more than once according to a scan pattern and expose the region(s) to the photoactivating light. The photoactivating light causes the cross-linking agent in the exposed region(s) to react with oxygen to generate cross-linking activity in the exposed region(s). The scan pattern causes a predetermined period of time to pass between visits by the laser beam to the exposed region(s), the predetermined period of time allowing oxygen in the exposed region(s) to replenish.Type: ApplicationFiled: May 5, 2023Publication date: November 2, 2023Inventors: Desmond C. Adler, Mikhail Smirnov, David Usher, Behrouz Tavakol, Jason Hill, Jie Zhang, Amit Mukherjee, Alex Yildizyan
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Patent number: 11642244Abstract: A system for treating an eye includes a laser light source providing photoactivating light. The system includes a scanning system to receive the photoactivating light as a laser beam and to move the laser beam over a cornea treated with a cross-linking agent. The system includes a controller that provides control signal(s) to programmatically control the laser light source and the scanning system. The control signal(s) cause the laser beam to visit region(s) of the cornea more than once according to a scan pattern and expose the region(s) to the photoactivating light. The photoactivating light causes the cross-linking agent in the exposed region(s) to react with oxygen to generate cross-linking activity in the exposed region(s). The scan pattern causes a predetermined period of time to pass between visits by the laser beam to the exposed region(s), the predetermined period of time allowing oxygen in the exposed region(s) to replenish.Type: GrantFiled: August 6, 2020Date of Patent: May 9, 2023Assignee: Avedro, Inc.Inventors: Desmond C. Adler, Mikhail Smirnov, David Usher, Behrouz Tavakol, Jason Hill, Jie Zhang, Amit Mukherjee, Alex Yildizyan
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Publication number: 20210038428Abstract: A system for treating an eye includes a laser light source providing photoactivating light. The system includes a scanning system to receive the photoactivating light as a laser beam and to move the laser beam over a cornea treated with a cross-linking agent. The system includes a controller that provides control signal(s) to programmatically control the laser light source and the scanning system. The control signal(s) cause the laser beam to visit region(s) of the cornea more than once according to a scan pattern and expose the region(s) to the photoactivating light. The photoactivating light causes the cross-linking agent in the exposed region(s) to react with oxygen to generate cross-linking activity in the exposed region(s). The scan pattern causes a predetermined period of time to pass between visits by the laser beam to the exposed region(s), the predetermined period of time allowing oxygen in the exposed region(s) to replenish.Type: ApplicationFiled: August 6, 2020Publication date: February 11, 2021Inventors: Desmond C. Adler, Mikhail Smirnov, David Usher, Behrouz Tavakol, Jason Hill, Jie Zhang, Amit Mukherjee, Alex Yildizyan
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Patent number: 10687777Abstract: In part, the invention relates to processing, tracking and registering angiography images and elements in such images relative to images from an intravascular imaging modality such as, for example, optical coherence tomography (OCT). Registration between such imaging modalities is facilitated by tracking of a marker of the intravascular imaging probe performed on the angiography images obtained during a pullback. Further, detecting and tracking vessel centerlines is used to perform a continuous registration between OCT and angiography images in one embodiment.Type: GrantFiled: March 5, 2018Date of Patent: June 23, 2020Assignee: LIGHTLAB IMAGING, INC.Inventors: Lorina Dascal, Itai Winkler, Stavit Cohen, Amit Cohen, Desmond C. Adler
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Publication number: 20200107953Abstract: A system for treating an eye includes a light source configured to provide photoactivating light that photoactivates a cross-linking agent applied to a cornea. The system includes one or more optical elements configured to receive the photoactivating light and produce a beam that defines a spot of the photoactivating light. The system includes a scanning system configured to receive the beam of the photoactivating light and to scan the spot of the photoactivating light along a first axis and a second axis to form a scan pattern on the cornea to generate cross-linking activity.Type: ApplicationFiled: October 9, 2019Publication date: April 9, 2020Inventors: Desmond C. Adler, David Usher, Alex Yildizyan
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Publication number: 20180192983Abstract: In part, the invention relates to processing, tracking and registering angiography images and elements in such images relative to images from an intravascular imaging modality such as, for example, optical coherence tomography (OCT). Registration between such imaging modalities is facilitated by tracking of a marker of the intravascular imaging probe performed on the angiography images obtained during a pullback. Further, detecting and tracking vessel centerlines is used to perform a continuous registration between OCT and angiography images in one embodiment.Type: ApplicationFiled: March 5, 2018Publication date: July 12, 2018Applicant: LightLab Imaging, Inc.Inventors: Lorina Dascal, Itai Winkler, Stavit Cohen, Amit Cohen, Desmond C. Adler
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Patent number: 9907527Abstract: In part, the invention relates to processing, tracking and registering angiography images and elements in such images relative to images from an intravascular imaging modality such as, for example, optical coherence tomography (OCT). Registration between such imaging modalities is facilitated by tracking of a marker of the intravascular imaging probe performed on the angiography images obtained during a pullback. Further, detecting and tracking vessel centerlines is used to perform a continuous registration between OCT and angiography images in one embodiment.Type: GrantFiled: March 2, 2016Date of Patent: March 6, 2018Assignee: LIGHTLAB IMAGING, INC.Inventors: Lorina Dascal, Itai Winkler, Stavit Cohen, Amit Cohen, Desmond C. Adler
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Publication number: 20160174925Abstract: In part, the invention relates to processing, tracking and registering angiography images and elements in such images relative to images from an intravascular imaging modality such as, for example, optical coherence tomography (OCT). Registration between such imaging modalities is facilitated by tracking of a marker of the intravascular imaging probe performed on the angiography images obtained during a pullback. Further, detecting and tracking vessel centerlines is used to perform a continuous registration between OCT and angiography images in one embodiment.Type: ApplicationFiled: March 2, 2016Publication date: June 23, 2016Inventors: Lorina Dascal, Itai Winkler, Stavit Cohen, Amit Cohen, Desmond C. Adler
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Patent number: 9295392Abstract: A method is described for computing a statistically significant difference between dysplasia and Barrett's esophagus (both with and without inflammatory component) using a discriminate function with diffuse reflectance measurements performed at a minimum of four different wavelengths of 485, 513, 598, and 629 nm. The discriminate function found depends both on local blood fraction volume THB and oxygenation SO2. A pull-back approach of spectral data acquisition is disclosed which takes into account tissue motility in esophagus and measurement geometry peculiarities. The pull-back approach provides a significant improvement of measurement reproducibility and reduction of data deviation by 75-100%, resulting in a better discrimination between different histological groups.Type: GrantFiled: September 24, 2012Date of Patent: March 29, 2016Assignee: NOVADAQ TECHNOLOGIES INC.Inventors: Alexandre Douplik, Desmond C. Adler, Brian C. Wilson, Norman Marcon
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Patent number: 8923349Abstract: A control system for improving and stabilizing Fourier domain mode locking (FDML) operation. The control system may also provide regulation of FDML operational parameters such as filter tuning, laser gain, polarization, polarization chromaticity, elliptical polarization retardance, and/or dispersion. The control system may be located internal to or external from the FDML laser cavity.Type: GrantFiled: April 11, 2013Date of Patent: December 30, 2014Assignee: Massachusettes Institute of TechnologyInventors: Robert A. Huber, James G. Fujimoto, Desmond C. Adler
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Publication number: 20130178748Abstract: A method is described for computing a statistically significant difference between dysplasia and Barrett's esophagus (both with and without inflammatory component) using a discriminate function with diffuse reflectance measurements performed at a minimum of four different wavelengths of 485, 513, 598, and 629 nm. The discriminate function found depends both on local blood fraction volume THB and oxygenation SO2. A pull-back approach of spectral data acquisition is disclosed which takes into account tissue motility in esophagus and measurement geometry peculiarities. The pull-back approach provides a significant improvement of measurement reproducibility and reduction of data deviation by 75-100%, resulting in a better discrimination between different histological groups.Type: ApplicationFiled: September 24, 2012Publication date: July 11, 2013Applicant: NOVADAQ TECHNOLOGIES INC.Inventors: Alexandre Douplik, Desmond C. Adler, Brian C. Wilson, Norman Marcon
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Patent number: 8315282Abstract: A control system for improving and stabilizing Fourier domain mode locking (FDML) operation. The control system may also provide regulation of FDML operational parameters such as filter tuning, laser gain, polarization, polarization chromaticity, elliptical polarization retardance, and/or dispersion. The control system may be located internal to or external from the FDML laser cavity.Type: GrantFiled: October 22, 2008Date of Patent: November 20, 2012Assignee: Massachusetts Institute of TechnologyInventors: Robert A. Huber, James G. Fujimoto, Desmond C. Adler
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Publication number: 20100087741Abstract: A method is described for computing a statistically significant difference between dysplasia and Barrett's esophagus (both with and without inflammatory component) using a discriminate function with diffuse reflectance measurements performed at a minimum of four different wavelengths of 485, 513, 598, and 629 nm. The discriminate function found depends both on local blood fraction volume THB and oxygenation SO2. A pull-back approach of spectral data acquisition is disclosed which takes into account tissue motility in esophagus and measurement geometry peculiarities. The pull-back approach provides a significant improvement of measurement reproducibility and reduction of data deviation by 75-100%, resulting in a better discrimination between different histological groups.Type: ApplicationFiled: October 2, 2009Publication date: April 8, 2010Applicant: NOVADAQ TECHNOLOGIES INC.Inventors: Alexandre Douplik, Desmond C. Adler, Brian C. Wilson, Norman Marcon
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Publication number: 20090174931Abstract: A control system for improving and stabilizing Fourier domain mode locking (FDML) operation. The control system may also provide regulation of FDML operational parameters such as filter tuning, laser gain, polarization, polarization chromaticity, elliptical polarization retardance, and/or dispersion. The control system may be located internal to or external from the FDML laser cavity.Type: ApplicationFiled: October 22, 2008Publication date: July 9, 2009Inventors: Robert A. Huber, James G. Fujimoto, Desmond C. Adler