Patents by Inventor Desmond Christopher Adler
Desmond Christopher Adler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240108453Abstract: Methods employ bioresorbable corneal implants to treat corneal ectatic disorders and/or refractive errors. The corneal implants may be formed from a porous microstructure that can encourage the proliferation of endogenous keratocytes. As such, the corneal implants act as tissue scaffolds that promote tissue growth to increase the biomechanical stability and/or change the shape of the cornea. Over time, the corneal implants may resorb via hydrolysis or enzymatic breakdown, negating the risks of inflammation, scarring, or foreign body response. The corneal implants may also employ drug coating(s) to promote tissue growth.Type: ApplicationFiled: December 14, 2023Publication date: April 4, 2024Inventors: Desmond Christopher Adler, David Usher
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Publication number: 20240009031Abstract: A micro-device for corneal cross-linking treatment includes a body including an outer portion and an inner portion. The inner portion is coupled to the outer portion which is disposed about a periphery of the inner portion. When the body is against an eye surface, the outer portion contacts the eye surface and the inner portion defines a chamber over a cornea of the eye. The micro-device includes an illumination system including a micro-optical element and an optical fiber. The micro-optical element includes micro-LEDs configured to direct photoactivating light through the inner portion to the cornea of the eye when the body is positioned against the surface of the eye. The photoactivating light generates cross-linking activity with a cross-linking agent applied to the cornea. The optical fiber couples the micro-optical element to a light source and includes a surface configured to reflect the photoactivating light to the micro-optical element.Type: ApplicationFiled: September 21, 2023Publication date: January 11, 2024Inventors: Desmond Christopher Adler, Reza Zadno, Paul Bavier, David C. Iannetta, Jun Zhang
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Patent number: 11864990Abstract: Systems and methods employ bioresorbable corneal implants to treat corneal ectatic disorders and/or refractive errors. The corneal implants may be formed from a porous microstructure that can encourage the proliferation of endogenous keratocytes. As such, the corneal implants act as tissue scaffolds that promote tissue growth to increase the biomechanical stability and/or change the shape of the cornea. Over time, the corneal implants may resorb via hydrolysis or enzymatic breakdown, negating the risks of inflammation, scarring, or foreign body response. The corneal implants may also employ drug coating(s) to promote tissue growth.Type: GrantFiled: February 26, 2020Date of Patent: January 9, 2024Assignee: AVEDRO, INC.Inventors: Desmond Christopher Adler, David Usher
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Patent number: 11766356Abstract: A micro-device for corneal cross-linking treatment includes a body including an outer portion and an inner portion. The outer portion is disposed about a periphery of the inner portion. The inner portion is shaped such that, when the body is positioned against a surface of an eye, the outer portion contacts the surface of the eye and the inner portion defines a chamber over a cornea of the eye. The micro-device includes an illumination system including a micro-optical element coupled to the body. The micro-optical element is configured to direct photoactivating light to the cornea of the eye when the body is positioned against the surface of the eye. The photoactivating light generates cross-linking activity with a cross-linking agent applied to the cornea.Type: GrantFiled: March 8, 2019Date of Patent: September 26, 2023Assignee: AVEDRO, INC.Inventors: Desmond Christopher Adler, Reza Zadno, Paul Bavier, David C. Iannetta, Jun Zhang
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Publication number: 20230103346Abstract: In a corneal measurement system, an optical element focuses an excitation light to an area of corneal tissue at a selected depth. In response, a fluorescing agent applied to the cornea generates a fluorescence emission. An aperture of a pinhole structure selectively transmits the fluorescence emission from the area of corneal tissue at the selected depth. A detector captures the selected fluorescence emission transmitted by the aperture and communicates information relating to a measurement of the selected fluorescence emission captured by the detector. A controller receives the information from the detector and determines a measurement of the fluorescing agent in the area of corneal tissue at the selected depth. The system may include a scan mechanism that causes the optical element to scan the cornea at a plurality of depths, and the controller may determine a measurement of the fluorescing agent in the cornea as a function of depth.Type: ApplicationFiled: December 9, 2022Publication date: April 6, 2023Inventors: Desmond Christopher Adler, Jun A. Zhang, Mikhail Z. Smirnov, Marc D. Friedman, David Usher, Grace Elizabeth Lytle, David C. Iannetta
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Patent number: 11529050Abstract: In a corneal measurement system, an optical element focuses an excitation light to an area of corneal tissue at a selected depth. In response, a fluorescing agent applied to the cornea generates a fluorescence emission. An aperture of a pinhole structure selectively transmits the fluorescence emission from the area of corneal tissue at the selected depth. A detector captures the selected fluorescence emission transmitted by the aperture and communicates information relating to a measurement of the selected fluorescence emission captured by the detector. A controller receives the information from the detector and determines a measurement of the fluorescing agent in the area of corneal tissue at the selected depth. The system may include a scan mechanism that causes the optical element to scan the cornea at a plurality of depths, and the controller may determine a measurement of the fluorescing agent in the cornea as a function of depth.Type: GrantFiled: April 3, 2020Date of Patent: December 20, 2022Assignee: AVEDRO, INC.Inventors: Desmond Christopher Adler, Jun Zhang, Mikhail Z. Smirnov, Marc D. Friedman, David Usher, Grace Elizabeth Lytle, David C. Iannetta
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Publication number: 20220193439Abstract: An example antimicrobial treatment system includes an illumination system configured to deliver illumination that activates a photosensitizing agent applied to a cornea. The system also includes a controller configured to control the illumination system. The controller detects an ulcerative region on a cornea and causes the illumination system to deliver the illumination to activate the photosensitizing agent applied to the ulcerative region according to a set of parameters for treating the ulcerative region. The illumination is restricted to the ulcerative region, and activation of the photosensitizing agent in the ulcerative region generates an antimicrobial effect.Type: ApplicationFiled: December 17, 2021Publication date: June 23, 2022Inventors: Desmond Christopher Adler, Jason Hill, David Usher, Mikhail Smirnov, Ahalya Viswanathan
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Publication number: 20210000646Abstract: A micro-device for corneal cross-linking treatment includes a body including an outer portion and an inner portion. The outer portion is disposed about a periphery of the inner portion. The inner portion is shaped such that, when the body is positioned against a surface of an eye, the outer portion contacts the surface of the eye and the inner portion defines a chamber over a cornea of the eye. The micro-device includes an illumination system including a micro-optical element coupled to the body. The micro-optical element is configured to direct photoactivating light to the cornea of the eye when the body is positioned against the surface of the eye. The photoactivating light generates cross-linking activity with a cross-linking agent applied to the cornea.Type: ApplicationFiled: March 8, 2019Publication date: January 7, 2021Inventors: Desmond Christopher Adler, Reza Zadno, Paul Bavier, David C. Iannetta, Jun Zhang
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Publication number: 20200397613Abstract: A corneal cross-linking system includes a light source configured to emit a photoactivating light. The system includes a spatial light modulator configured to receive the photoactivating light from the light source and provide a pixelated illumination. The spatial light modulator defines a maximum area for the pixelated illumination. The system includes a controller configured to cause the spatial light modulator to project a first pixelated illumination onto the cornea to photoactivate a cross-linking agent applied to a treatment area. The first pixelated illumination has an area that is smaller than the maximum area defined by the spatial light modulator. The controller is configured to determine movement of the cornea. In response to the movement, the controller controls the spatial light modulator to project a second pixelated illumination to the treatment area based on a translation and/or transformation of the first pixelated illumination to continue photoactivating the cross-linking agent.Type: ApplicationFiled: March 5, 2019Publication date: December 24, 2020Inventors: Desmond Christopher Adler, David Usher, Mikhail Smirnov
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Publication number: 20200268505Abstract: Systems and methods employ bioresorbable corneal implants to treat corneal ectatic disorders and/or refractive errors. The corneal implants may be formed from a porous microstructure that can encourage the proliferation of endogenous keratocytes. As such, the corneal implants act as tissue scaffolds that promote tissue growth to increase the biomechanical stability and/or change the shape of the cornea. Over time, the corneal implants may resorb via hydrolysis or enzymatic breakdown, negating the risks of inflammation, scarring, or foreign body response. The corneal implants may also employ drug coating(s) to promote tissue growth.Type: ApplicationFiled: February 26, 2020Publication date: August 27, 2020Inventors: Desmond Christopher Adler, David Usher
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Publication number: 20200229692Abstract: In a corneal measurement system, an optical element focuses an excitation light to an area of corneal tissue at a selected depth. In response, a fluorescing agent applied to the cornea generates a fluorescence emission. An aperture of a pinhole structure selectively transmits the fluorescence emission from the area of corneal tissue at the selected depth. A detector captures the selected fluorescence emission transmitted by the aperture and communicates information relating to a measurement of the selected fluorescence emission captured by the detector. A controller receives the information from the detector and determines a measurement of the fluorescing agent in the area of corneal tissue at the selected depth. The system may include a scan mechanism that causes the optical element to scan the cornea at a plurality of depths, and the controller may determine a measurement of the fluorescing agent in the cornea as a function of depth.Type: ApplicationFiled: April 3, 2020Publication date: July 23, 2020Inventors: Desmond Christopher Adler, Jun Zhang, Mikhail Z. Smirnov, Marc D. Friedman, David Usher, Grace Elizabeth Lytle, David C. Iannetta
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Patent number: 10631726Abstract: In a corneal measurement system, an optical element focuses an excitation light to an area of corneal tissue at a selected depth. In response, a fluorescing agent applied to the cornea generates a fluorescence emission. An aperture of a pinhole structure selectively transmits the fluorescence emission from the area of corneal tissue at the selected depth. A detector captures the selected fluorescence emission transmitted by the aperture and communicates information relating to a measurement of the selected fluorescence emission captured by the detector. A controller receives the information from the detector and determines a measurement of the fluorescing agent in the area of corneal tissue at the selected depth. The system may include a scan mechanism that causes the optical element to scan the cornea at a plurality of depths, and the controller may determine a measurement of the fluorescing agent in the cornea as a function of depth.Type: GrantFiled: January 11, 2018Date of Patent: April 28, 2020Assignee: Avedro, Inc.Inventors: Desmond Christopher Adler, Jun Zhang, Mikhail Z. Smirnov, Marc D. Friedman, David Usher, Grace Elizabeth Lytle, David C. Iannetta
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Patent number: 10331099Abstract: A data collection system controller that includes a housing such as a cover. The housing includes a user facing section and a support facing section defining a hole. The controller also includes a first input device adjacent the user facing section and a second input device. The second input device includes a knob comprising a third input device and a rotatable shaft extending through the hole and partially disposed within the knob. In one embodiment, the second input device is an XYZ joystick with a button. In one embodiment, the joystick and the first input device are angled relative to each other on either side of an elbow joint. In part, the invention relates to a method of controlling the display of image data obtained with respect to a blood vessel.Type: GrantFiled: May 25, 2018Date of Patent: June 25, 2019Assignee: LIGHTLAB IMAGING, INC.Inventors: Desmond Christopher Adler, Joshua M. Gomes, David Winston, Susan Moynihan
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Publication number: 20180275622Abstract: A data collection system controller that includes a housing such as a cover. The housing includes a user facing section and a support facing section defining a hole. The controller also includes a first input device adjacent the user facing section and a second input device. The second input device includes a knob comprising a third input device and a rotatable shaft extending through the hole and partially disposed within the knob. In one embodiment, the second input device is an XYZ joystick with a button. In one embodiment, the joystick and the first input device are angled relative to each other on either side of an elbow joint. In part, the invention relates to a method of controlling the display of image data obtained with respect to a blood vessel.Type: ApplicationFiled: May 25, 2018Publication date: September 27, 2018Applicant: LightLab Imaging, Inc.Inventors: Desmond Christopher Adler, Joshua M. Gomes, David Winston, Susan Moynihan
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Publication number: 20180206719Abstract: In a corneal measurement system, an optical element focuses an excitation light to an area of corneal tissue at a selected depth. In response, a fluorescing agent applied to the cornea generates a fluorescence emission. An aperture of a pinhole structure selectively transmits the fluorescence emission from the area of corneal tissue at the selected depth. A detector captures the selected fluorescence emission transmitted by the aperture and communicates information relating to a measurement of the selected fluorescence emission captured by the detector. A controller receives the information from the detector and determines a measurement of the fluorescing agent in the area of corneal tissue at the selected depth. The system may include a scan mechanism that causes the optical element to scan the cornea at a plurality of depths, and the controller may determine a measurement of the fluorescing agent in the cornea as a function of depth.Type: ApplicationFiled: January 11, 2018Publication date: July 26, 2018Inventors: Desmond Christopher Adler, Jun Zhang, Mikhail Z. Smirnov, Marc D. Friedman, David Usher, Grace Elizabeth Lytle, David C. Iannetta
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Patent number: 9989945Abstract: A data collection system controller that includes a housing such as a cover. The housing includes a user facing section and a support facing section defining a hole. The controller also includes a first input device adjacent the user facing section and a second input device. The second input device includes a knob comprising a third input device and a rotatable shaft extending through the hole and partially disposed within the knob. In one embodiment, the second input device is an XYZ joystick with a button. In one embodiment, the joystick and the first input device are angled relative to each other on either side of an elbow joint. In part, the invention relates to a method of controlling the display of image data obtained with respect to a blood vessel.Type: GrantFiled: May 27, 2015Date of Patent: June 5, 2018Assignee: LIGHTLAB IMAGING, INC.Inventors: Desmond Christopher Adler, Joshua M. Gomes, David Winston, Susan Moynihan
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Publication number: 20150370229Abstract: A data collection system controller that includes a housing such as a cover. The housing includes a user facing section and a support facing section defining a hole. The controller also includes a first input device adjacent the user facing section and a second input device. The second input device includes a knob comprising a third input device and a rotatable shaft extending through the hole and partially disposed within the knob. In one embodiment, the second input device is an XYZ joystick with a button. In one embodiment, the joystick and the first input device are angled relative to each other on either side of an elbow joint. In part, the invention relates to a method of controlling the display of image data obtained with respect to a blood vessel.Type: ApplicationFiled: May 27, 2015Publication date: December 24, 2015Applicant: LIGHTLAB IMAGING, INC.Inventors: Desmond Christopher Adler, Joshua M. Gomes, David Winston, Susan Moynihan