Patents by Inventor Detlef Bruno Igor Schuppan

Detlef Bruno Igor Schuppan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide-based carrier devices for stellate cells
    Publication number: 20080267877
    Abstract: A compound includes a carrier molecule wherein the carrier molecule is linked to a further molecule, wherein the further molecule is at least one cyclic peptide in which the cyclic peptide portion thereof contains at least one sequence encoding a cell receptor recognizing peptide (RRP) and with the proviso that the compound is not a naturally occurring receptor agonist or antagonist. Preferably, the RRP is a receptor specific for Hepatic Stellate Cells (HSC) or a receptor that is up-regulated on HSC during disease. The RFP may be chosen from among a PDGF receptor, a collagen type VI receptor, cytokine receptor(s) such as TGB?, INF? and interleukin?. The cyclic portion of the peptide can contain at least one amino acid sequence RGD or KPT.
    Type: Application
    Filed: March 24, 2008
    Publication date: October 30, 2008
    Applicants: Stichting voor de Technische Wetenschappen, Rijksuniversiteit Groningen
    Inventors: Klaas Poelstra, Eleonora Beljaars, Dirk Klaas Fokke Meijer, Detlef Bruno Igor Schuppan
  • Method for targeting cells involved in sclerotic and/or fibrotic diseases
    Patent number: 7348313
    Abstract: A compound includes a carrier molecule wherein the carrier molecule is linked to a further molecule, wherein the further molecule is at least one cyclic peptide in which the cyclic peptide portion thereof contains at least one sequence encoding a cell receptor recognizing peptide (RRP) and with the proviso that the compound is not a naturally occurring receptor agonist or antagonist. Preferably, the RRP is a receptor specific for Hepatic Stellate Cells (HSC) or a receptor that is up-regulated on HSC during disease. The RFP may be chosen from among a PDGF receptor, a collagen type VI receptor, cytokine receptor(s) such as TGB?, INF? and interleukin?. The cyclic portion of the peptide can contain at least one amino acid sequence RGD or KPT.
    Type: Grant
    Filed: December 15, 2004
    Date of Patent: March 25, 2008
    Assignees: Stichting Voor de Technische Wetenschappen, Rijksuniversiteit Groningen
    Inventors: Klaus Poelstra, Eleonora Beljaars, Drik Klaus Fokke Meijer, Detlef Bruno Igor Schuppan
  • Peptide-based carrier devices for stellate cells
    Patent number: 6844319
    Abstract: The present invention relates to a compound comprising a carrier molecule, said carrier molecule being linked to a further molecule, said further molecule being at least one cyclic peptide, said cyclic peptide comprising in the cyclic peptide portion thereof at least one sequence encoding a cell receptor recognising peptide (RRP) and with the proviso that the compound is not a naturally occuring receptor agonist or antagonist. Preferably, the RRP is of a receptor specific for Hepatic Stellate Cells (HSC) or a receptor that is upregulated on HSC during disease. In particular, the RRP may be of a receptor selected from the group of PDGF receptor, collagen type VI receptor, cytokine receptor(s) such as TGF?, IFN? and interleukin 1?. Preferably, the cyclic portion of the cyclic peptide comprises at least the amino acid sequence RGD or KPT.
    Type: Grant
    Filed: October 8, 1998
    Date of Patent: January 18, 2005
    Assignees: Stichting voor de Technische Wetenschappen, Rijksuniversiteit Groningen
    Inventors: Klaas Poelstra, Eleonora Beljaars, Dirk Klaas Fokke Meijer, Detlef Bruno Igor Schuppan