Patents by Inventor Detlef Eisenkrätzer
Detlef Eisenkrätzer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240132829Abstract: The invention relates to a comparison unit (130) configured for determining if a first pH measuring device of a first tank (104; 106) is affected by a pH-measuring problem, the comparison unit being configured for: receiving a first CO2 concentration and a first pH value, the first CO2 concentration being a CO2 concentration of a first gas volume above a medium in a first tank, the first CO2 concentration and the first pH value being measured at a first time when the medium in the first tank is in pH-CO2 equilibrium state with the first gas volume and before said equilibrium state is modified by the metabolism of a cell culture in the first tank, the first pH value being a measured value provided by a first pH measuring device operatively coupled to the first tank (102); receiving a second CO2 concentration and a second pH value, the second CO2 concentration being a CO2 concentration of a second gas volume above a medium in a second tank, the second CO2 concentration and the second pH value being measuredType: ApplicationFiled: December 1, 2023Publication date: April 25, 2024Inventors: Detlef EISENKRAETZER, Christian KLINGER, Katrin GREPPMAIR
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Patent number: 11866686Abstract: The invention relates to a comparison unit (130) configured for determining if a first pH measuring device of a first tank (104; 106) is affected by a pH-measuring problem, the comparison unit being configured for: receiving a first CO2 concentration and a first pH value, the first CO2 concentration being a CO2 concentration of a first gas volume above a medium in a first tank, the first CO2 concentration and the first pH value being measured at a first time when the medium in the first tank is in pH-CO2 equilibrium state with the first gas volume and before said equilibrium state is modified by the metabolism of a cell culture in the first tank, the first pH value being a measured value provided by a first pH measuring device operatively coupled to the first tank (102); receiving a second CO2 concentration and a second pH value, the second CO2 concentration being a CO2 concentration of a second gas volume above a medium in a second tank, the second CO2 concentration and the second pH value being measuredType: GrantFiled: January 13, 2022Date of Patent: January 9, 2024Assignee: Hoffmann-La Roche, Inc.Inventors: Detlef Eisenkraetzer, Christian Klinger, Katrin Greppmair
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Patent number: 11473042Abstract: The invention relates to a system (100) for monitoring deviations of a state of a cell culture in a bioreactor (104, 106) from a reference state of a cell culture in a reference bioreactor (102). The bioreactor comprises the same medium (M1) as the reference bioreactor.Type: GrantFiled: October 28, 2016Date of Patent: October 18, 2022Assignee: Hoffmann-La Roche, Inc.Inventors: Detlef Eisenkraetzer, Christian Klinger, Katrin Greppmair, Claudia Schmidberger
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Publication number: 20220325223Abstract: The invention relates to a comparison unit (130) configured for determining if a first pH measuring device of a first tank (104; 106) is affected by a pH-measuring problem, the comparison unit being configured for: receiving a first CO2 concentration and a first pH value, the first CO2 concentration being a CO2 concentration of a first gas volume above a medium in a first tank, the first CO2 concentration and the first pH value being measured at a first time when the medium in the first tank is in pH-CO2 equilibrium state with the first gas volume and before said equilibrium state is modified by the metabolism of a cell culture in the first tank, the first pH value being a measured value provided by a first pH measuring device operatively coupled to the first tank (102); receiving a second CO2 concentration and a second pH value, the second CO2 concentration being a CO2 concentration of a second gas volume above a medium in a second tank, the second CO2 concentration and the second pH value being measuredType: ApplicationFiled: January 13, 2022Publication date: October 13, 2022Inventors: Detlef Eisenkraetzer, Christian Klinger, Katrin Greppmair
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Patent number: 11371006Abstract: The invention relates to a comparison unit (130) configured for determining if a first pH measuring device of a first tank (104; 106) is affected by a pH-measuring problem, the comparison unit being configured for: —receiving a first CO2 concentration and a first pH value, the first CO2 concentration being a CO2 concentration of a first gas volume above a medium in a first tank, the first CO2 concentration and the first pH value being measured at a first time when the medium in the first tank is in pH-CO2 equilibrium state with the first gas volume and before said equilibrium state is modified by the metabolism of a cell culture in the first tank, the first pH value being a measured value provided by a first pH measuring device operatively coupled to the first tank (102); —receiving a second CO2 concentration and a second pH value, the second CO2 concentration being a CO2 concentration of a second gas volume above a medium in a second tank, the second CO2 concentration and the second pH value being measured aType: GrantFiled: October 28, 2016Date of Patent: June 28, 2022Assignee: Hoffman-La Roche, Inc.Inventors: Detlef Eisenkraetzer, Christian Klinger, Katrin Greppmair
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Publication number: 20190367854Abstract: The invention relates to a system (100) for monitoring deviations of a state of a cell culture in a bioreactor (104, 106) from a reference state of a cell culture in a reference bioreactor (102). The bioreactor comprises the same medium (M1) as the reference bioreactor.Type: ApplicationFiled: October 28, 2016Publication date: December 5, 2019Inventors: Detlef Eisenkraetzer, Christian Klinger, Katrin Greppmair, Claudia Schmidberger
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Publication number: 20180273885Abstract: The invention relates to a system (100) for monitoring deviations of a state of a cell culture in a bioreactor (104, 106) from a reference state of a cell culture in a reference bioreactor (102). The bioreactor comprises the same medium (M1) as the reference bioreactor.Type: ApplicationFiled: October 28, 2016Publication date: September 27, 2018Inventors: Detlef Eisenkraetzer, Christian Klinger, Katrin Greppmair, Claudia Schmidberger
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Publication number: 20180216059Abstract: The invention relates to a comparison unit (130) configured for determining if a first pH measuring device of a first tank (104; 106) is affected by a pH-measuring problem, the comparison unit being configured for: —receiving a first CO2 concentration and a first pH value, the first CO2 concentration being a CO2 concentration of a first gas volume above a medium in a first tank, the first CO2 concentration and the first pH value being measured at a first time when the medium in the first tank is in pH-CO2 equilibrium state with the first gas volume and before said equilibrium state is modified by the metabolism of a cell culture in the first tank, the first pH value being a measured value provided by a first pH measuring device operatively coupled to the first tank (102); —receiving a second CO2 concentration and a second pH value, the second CO2 concentration being a CO2 concentration of a second gas volume above a medium in a second tank, the second CO2 concentration and the second pH value being measured aType: ApplicationFiled: October 28, 2016Publication date: August 2, 2018Inventors: Detlef Eisenkraetzer, Christian Klinger, Katrin Greppmair
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Patent number: 8460895Abstract: A method for the recombinant production of a polypeptide in a eukaryotic host cell modified in the citrate cycle is described, wherein the method comprises cultivating the eukaryotic host cell in a suitable medium under conditions which allow the expression of the polypeptide, wherein the content of dissolved CO2 (pCO2) in the medium is maintained at a constant value in the range of 10% to 20%.Type: GrantFiled: March 11, 2009Date of Patent: June 11, 2013Assignee: Hoffmann-La Roche Inc.Inventors: Detlef Eisenkraetzer, Jochen Gaetgens, Alexander Jockwer, Christian Klinger, Thomas Noll, Barbara Bezdek-Sueess
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Publication number: 20110159539Abstract: A method for the recombinant production of a polypeptide in a eukaryotic host cell modified in the citrate cycle is described, wherein the method comprises cultivating the eukaryotic host cell in a suitable medium under conditions which allow the expression of the polypeptide, wherein the content of dissolved CO2 (pCO2) in the medium is maintained at a constant value in the range of 10% to 20%.Type: ApplicationFiled: March 11, 2009Publication date: June 30, 2011Inventors: Detlef Eisenkraetzer, Alexander Jockwer, Christian Klinger, Jochen Gaetgens, Thomas Noll, Barbara Bezdek-Sueess
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Patent number: 7374333Abstract: An agitator for use on an agitator shaft having an axis of rotation. The agitator has a blade mount configured and dimensioned to receive the agitator shaft and being further configured and dimensioned so as to hold a plurality of agitator blades radially with respect to the axis of rotation. Each agitator blade has a plurality of segments, including an upper segment relative to the axis of rotation and a lower segment relative to the axis of rotation. The segments are inclined at an acute angle relative to the axis of rotation in the direction of rotation, wherein the acute angle changes continuously or stepwise from about 25° at the upper segment to about 65° at the lower segment.Type: GrantFiled: April 20, 2005Date of Patent: May 20, 2008Assignee: Hoffmann-La Roche Inc.Inventors: Detlef Eisenkraetzer, Andreas Haug
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Publication number: 20050243646Abstract: An agitator for use on an agitator shaft having an axis of rotation. The agitator has a blade mount configured and dimensioned to receive the agitator shaft and being further configured and dimensioned so as to hold a plurality of agitator blades radially with respect to the axis of rotation. Each agitator blade has a plurality of segments, including an upper segment relative to the axis of rotation and a lower segment relative to the axis of rotation. The segments are inclined at an acute angle relative to the axis of rotation in the direction of rotation, wherein the acute angle changes continuously or stepwise from about 25° at the upper segment to about 65° at the lower segment.Type: ApplicationFiled: April 20, 2005Publication date: November 3, 2005Inventors: Detlef Eisenkraetzer, Andreas Haug
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Patent number: 6743615Abstract: The present invention is a process for converting trimethylhydroquinone diacetate (TMHQ-DA) into trimethylhydroquinone-1-monoacetate (TMHQ-1-MA) by contacting TMHQ-DA with a lipase to effect an enzymatic monosaponification of the TMHQ-DA. Also provided are methods of making (all-rac)-&agr;-tocopherol and (all-rac)-&agr;-tocopherol acetate.Type: GrantFiled: February 19, 2002Date of Patent: June 1, 2004Assignee: Roche Vitamins, Inc.Inventors: Werner Bonrath, Detlef Eisenkraetzer, Valerie Enjolras, Reinhard Karge, Thomas Netscher, Michael Schneider
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Publication number: 20020161246Abstract: The present invention is a process for converting trimethylhydroquinone diacetate (TMHQ-DA) into trimethylhydroquinone-1-monoacetate (TMHQ-1-MA) by contacting TMHQ-DA with a lipase to effect an enzymatic monosaponification of the TMHQ-DA. Also provided are methods of making (all-rac)-&agr;-tocopherol and (all-rac)-&agr;-tocopherol acetate.Type: ApplicationFiled: February 19, 2002Publication date: October 31, 2002Inventors: Werner Bonrath, Detlef Eisenkraetzer, Valerie Enjolras, Reinhard Karge, Thomas Netscher, Michael Schneider
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Patent number: 6465220Abstract: The use of human polypeptide N-acetylgalactosaminytransferase T-4 (GalNAc-T4) to glycosylate substrates is disclosed. The action of GalNAc-T4 can complement the activities of GalNAc-T1, -T2 and -T3. The glycosylated substrates are useful in preparation of vaccines and anti-inflammatory agents. A method of producing the soluble form of the enzyme is also disclosed.Type: GrantFiled: December 21, 1998Date of Patent: October 15, 2002Assignee: GlycoZym ApSInventors: Frau Helle Hassan, Henrik Clausen, Eric Paul Bennett, Detlef Eisenkrätzer, Jochen Gätgens