Abstract: The application relates to devices and methods for assessing cognitive impairment and/or speech motor impairment in a subject. The method comprises analysing a voice recording from a word- reading test obtained from the subject by identifying a plurality of segments of the voice recording that correspond to single words or syllables and determining the number of correctly read words in the voice recording and/or the speech rate associated with the recording.

Abstract: Currently, assessing the severity and progression of symptoms in a subject diagnosed with a muscular disability, in particular SMA involves in-clinic monitoring and testing of the subject every 6 to 12 months. However, monitoring and testing a subject more frequently is preferred, but increasing the frequency of in-clinic monitoring and testing can be costly and inconvenient to the subject. Thus, assessing the severity and progression of symptoms via remote monitoring and testing of the subject outside of a clinic environment as described herein provides advantages in cost, ease of monitoring and convenience to the subject. Systems, methods and devices according to the present disclosure provide a diagnostic for assessing of the lung volume of a subject having a muscular disability, in particular SMA by active testing of the subject.

Abstract: Currently, assessing the severity and progression of symptoms in a subject diagnosed with a muscular disability, in particular SMA involves in-clinic monitoring and testing of the subject every 6 to 12 months. However, monitoring and testing a subject more frequently is preferred, but increasing the frequency of in-clinic monitoring and testing can be costly and inconvenient to the subject. Thus, assessing the severity and progression of symptoms via remote monitoring and testing of the subject outside of a clinic environment as described herein provides advantages in cost, ease of monitoring and convenience to the subject. Systems, methods and devices according to the present disclosure provide a diagnostic for assessing of the motor function of a subject having a muscular disability, in particular SMA by active testing of the subject.

Abstract: Currently, assessing the severity and progression of symptoms in a subject diagnosed with a muscular disability, in particular SMA involves in-clinic monitoring and testing of the subject every 6 to 12 months. However, monitoring and testing a subject more frequently is preferred, but increasing the frequency of in-clinic monitoring and testing can be costly and inconvenient to the subject. Thus, assessing the severity and progression of symptoms via remote monitoring and testing of the subject outside of a clinic environment as described herein provides advantages in cost, ease of monitoring and convenience to the subject. Systems, methods and devices according to the present disclosure provide a diagnostic for assessing of the distal hypotonia of a subject having a muscular disability, in particular SMA by active testing of the subject.

Abstract: Currently, assessing the severity and progression of symptoms in a subject diagnosed with a muscular disability, in particular SMA involves in-clinic monitoring and testing of the subject every 6 to 12 months. However, monitoring and testing a subject more frequently is preferred, but increasing the frequency of in-clinic monitoring and testing can be costly and inconvenient to the subject. Thus, assessing the severity and progression of symptoms via remote monitoring and testing of the subject outside of a clinic environment as described herein provides advantages in cost, ease of monitoring and convenience to the subject. Systems, methods and devices according to the present disclosure provide a diagnostic for assessing of the distal motor function of a subject having a muscular disability, in particular SMA by active testing of the subj ect.

Abstract: Aspects described herein relate to the field of disease tracking and diagnostics. Specifically, they relate to a method of assessing a muscular disability and, in particular, spinal muscular atrophy (SMA) in a subject comprising the steps of determining at least one parameter from a dataset of sensor measurements of the subject using a mobile device, and comparing the determined at least one parameter to a reference, whereby the muscular disability and, in particular, SMA will be assessed. Aspects described herein also relate to a mobile device comprising a processor, at least one pressure sensor and a database as well as software which is tangibly embedded to said device and, when running on said device, carries out the method of the invention as well as the use of such a device for assessing a muscular disability and, in particular, SMA.

Abstract: Currently, assessing the severity and progression of symptoms in a subject diagnosed with a muscular disability, in particular SMA involves in-clinic monitoring and testing of the subject every 6 to 12 months. However, monitoring and testing a subject more frequently is preferred, but increasing the frequency of in-clinic monitoring and testing can be costly and inconvenient to the subject. Thus, assessing the severity and progression of symptoms via remote monitoring and testing of the subject outside of a clinic environment as described herein provides advantages in cost, ease of monitoring and convenience to the subject. Systems, methods and devices according to the present disclosure provide a diagnostic for assessing of the axial motor function of a subject having a muscular disability, in particular SMA by active testing of the subject.

Abstract: Currently, assessing the severity and progression of symptoms in a subject diagnosed with a muscular disability, in particular SMA involves in-clinic monitoring and testing of the subject every 6 to 12 months. However, monitoring and testing a subject more frequently is preferred, but increasing the frequency of in-clinic monitoring and testing can be costly and inconvenient to the subject. Thus, assessing the severity and progression of symptoms via remote monitoring and testing of the subject outside of a clinic environment as described herein provides advantages in cost, ease of monitoring and convenience to the subject. Systems, methods and devices according to the present disclosure provide a diagnostic for assessing of the distal motor function of a subject having a muscular disability, in particular SMA by active testing of the subject.

Abstract: Currently, assessing the severity and progression of symptoms in a subject diagnosed with a muscular disability, in particular SMA involves in-clinic monitoring and testing of the subject every 6 to 12 months. However, monitoring and testing a subject more frequently is preferred, but increasing the frequency of in-clinic monitoring and testing can be costly and inconvenient to the subject. Thus, assessing the severity and progression of symptoms via remote monitoring and testing of the subject outside of a clinic environment as described herein provides advantages in cost, ease of monitoring and convenience to the subject. Systems, methods and devices according to the present disclosure provide a diagnostic for assessing of the axial motor function of a subject having a muscular disability, in particular SMA by active testing of the subject.

Abstract: Currently, assessing the severity and progression of symptoms in a subject diagnosed with a muscular disability, in particular SMA involves in-clinic monitoring and testing of the subject every 6 to 12 months. However, monitoring and testing a subject more frequently is preferred, but increasing the frequency of in-clinic monitoring and testing can be costly and inconvenient to the subject. Thus, assessing the severity and progression of symptoms via remote monitoring and testing of the subject outside of a clinic environment as described herein provides advantages in cost, ease of monitoring and convenience to the subject. Systems, methods and devices according to the present disclosure provide a diagnostic for assessing of the axial motor function of a subject having a muscular disability, in particular SMA by active testing of the subject.

Abstract: An active carbon filter intended for the fuel supply system of the internal combustion engine of a vehicle consists of a housing (1), inside of which flow paths for the different operating states of the filter are established between the ports (10, 11, 12) for connection with the top space of a tank, the ambient atmosphere and the intake manifold of the internal combustion engine. Proceeding from the port (11), these flow paths are characterized by chambers situated one in back of the other for pre-warming the air, an adjacent chamber (22) equipped with a first heating unit, an adjacent chamber (23) that accommodates active carbon particles, and another, adjacent chamber (28) that accommodates active carbon particles, is equipped with a second heating unit (34), and is provided with the ports (10, 12). This yields the establishment of optimal, in particular thermal conditions for the regeneration of the active carbon particles.

Abstract: An active carbon filter intended for the fuel supply system of the internal combustion engine of a vehicle consists of a housing (1), inside of which flow paths for the different operating states of the filter are established between the ports (10, 11, 12) for connection with the top space of a tank, the ambient atmosphere and the intake manifold of the internal combustion engine. Proceeding from the port (11), these flow paths are characterized by chambers situated one in back of the other for pre-warming the air, an adjacent chamber (22) equipped with a first heating unit, an adjacent chamber (23) that accommodates active carbon particles, and another, adjacent chamber (28) that accommodates active carbon particles, is equipped with a second heating unit (34), and is provided with the ports (10, 12). This yields the establishment of optimal, in particular thermal conditions for the regeneration of the active carbon particles.

Abstract: The invention relates to a nozzle arrangement (1), in particular for the injection of a fluid into a vacuum chamber, with a nozzle channel with a predetermined internal contour, whereby the nozzle channel leads into an exit opening. It is proposed that the internal contour of the nozzle channel be shaped concavely at least in part.

Abstract: The present invention is based on the determination of the global changes in gene expression in tissues or cells exposed to known toxins, in particular hepatotoxins, as compared to unexposed tissues or cells as well as the identification of individual genes that are differentially expressed upon toxin exposure. The invention includes methods of predicting at least one toxic effect of a compound, predicting the progression of a toxic effect of a compound, and predicting the hepatoxicity of a compound. Also provided are methods of predicting the mechanism of toxicity of a compound. In a further aspect, the invention provides probes comprising sequences that specifically hybridize to genes in Table 3 as well as solid supports comprising at least two of the said probes.

Abstract: The present invention is based on the determination of the global changes in gene expression in tissues or cells exposed to known toxins, in particular hepatotoxins, as compared to unexposed tissues or cells as well as the identification of individual genes that are differentially expressed upon toxin exposure. The invention includes methods of predicting at least one toxic effect of a compound, predicting the progression of a toxic effect of a compound, and predicting the hepatoxicity of a compound. Also provided are methods of predicting the mechanism of toxicity of a compound. In a further aspect, the invention provides probes comprising sequences that specifically hybridize to genes in Table 3 as well as solid supports comprising at least two of the said probes.

Abstract: The present invention is based on the determination of the global changes in gene expression in tissues or cells exposed to known toxins, in particular hepatotoxins, as compared to unexposed tissues or cells as well as the identification of individual genes that are differentially expressed upon toxin exposure. The invention includes methods of predicting at least one toxic effect of a compound, predicting the progression of a toxic effect of a compound, and predicting the hepatoxicity of a compound. Also provided are methods of predicting the mechanism of toxicity of a compound. In a further aspect, the invention provides probes comprising sequences that specifically hybridize to genes in Table 3 as well as solid supports comprising at least two of the said probes.

Abstract: A multilayered, coextruded tubular biaxially stretched casing, having oxygen and water vapor barrier properties plus reduced adhesion to contents, e.g., foodstuffs, contained within the casing, is disclosed. The tubular casing has five layers in the order of A|B|C|D|E. Outer layer A, contains as its principal component at least one polyamide. Layer B has oxygen barrier properties, and may be composed of a substantially hydrolyzed copolymer of ethylene and vinyl acetate. The core layer C contains as its principal component at least one polyamide. Layer D contains a modified polyolefin. Inner layer E (i.e., the layer that is in contact with the contents of the tubular casing) is a water vapor barrier layer, that contains as its principal component at least one member selected from the group consisting of homopolyolefin and copolyolefin. The tubular casing is useful for encasing foodstuffs, such as pasty or liquid foodstuffs.

Abstract: To investigate cellular changes in a living organism, in particular pathological cellular changes in a human being, the cellular substance is irradiated with two x-ray pulses in rapid succession. The difference in attenuation of the intensity between the two x-ray pulses is then evaluated.