Patents by Inventor Detleff Heller

Detleff Heller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for obtaining enantiomers of Cizolirtine
    Publication number: 20060142589
    Abstract: A process is described for the preparation of a precursor alcohol of Cizolirtine, (±)-2-[phenyl(1-methyl-1H-pyrazol-5-yl)methoxy]-N,N-dimethylethanamine and its enantiomers. The process involves the asymmetric reduction of a prochiral ketone in the presence of a chiral ruthenium (II) catalyst system including at least a bidentate phosphorous-containing ligand and a diamine ligand to yield chiral alcohols. The chiral alcohols are further O-alkylated to yield corresponding pharmaceutically active ethanamines.
    Type: Application
    Filed: January 24, 2005
    Publication date: June 29, 2006
    Inventors: Antoni Torrens Jover, Helmut Buschmann, Detleff Heller, Hans Drexler
  • Process for obtaining enantiomers of thienylazolylalcoxyethanamines
    Patent number: 6979742
    Abstract: A process is described for the preparation of a precursor alcohol of (±)-2-[thienyl(1-methyl-1H-pyrazol-5-yl)methoxy]-N,N-dimethyletanamine, and more generally for thyenylazolylalcoxyethanamines and their enantiomers. The process involves the asymmetric reduction of a prochiral ketone in the presence of a chiral ruthenium (II) catalyst system comprising at least a bidentate phosphorous-containing ligand and a diamine ligand to yield chiral alcohols. The chiral alcohols are further O-alkylated to yield corresponding pharmaceutically active ethanamines.
    Type: Grant
    Filed: January 24, 2005
    Date of Patent: December 27, 2005
    Assignee: Laboratorios del Dr. Esteve, S.A.
    Inventors: Antoni Torrens Jover, Helmut H. Buschmann, Detleff Heller, Hans Joachim Drexler