Patents by Inventor Detlev Kayser

Detlev Kayser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4182770
    Abstract: 1-(4-nitrophenyl)-2-methyl-4-nitroimidazole has been found to be highly useful as an alcohol deterrent.
    Type: Grant
    Filed: January 16, 1979
    Date of Patent: January 8, 1980
    Assignee: Merck Patent Gesellschaft mit beschraenkter Haftung
    Inventors: Ahmad Behpour, Detlev Kayser, Gerhard Martin
  • Patent number: 4072754
    Abstract: Hydratropic acid derivatives of the formula ##STR1## wherein R.sub.1 is H, alkyl of 1-4 carbon atoms, 2-acetamidoethyl, 1-methyl-4-piperidyl, or 2,3-dihydroxypropyl, and R.sub.2 is Hal, phenyl, 4-Hal-phenyl, 4-Hal-phenoxy, 4-Hal-phenoxymethyl, 1,2,3,4-tetrahydro-1-naphthyl, 1-pyrryl, piperidino, isoindolino, 1,2,3,4-tetrahydroquinolino, 1,2,3,4-tetrahydro-4-quinolyl or 1-methyl-1,2,3,4-tetrahydro-4-quinolyl, Hal being F, Cl, or Br, and the physiologically acceptable salts thereof, which possess cholesterol and triglyceride serum-level-lowering activity, can be prepared by reacting a phenol of the formula ##STR2## with a compound of the formula X--C(CH.sub.3)(C.sub. 6 H.sub.5)--COOR.sub.1 wherein X represents Cl, Br, I, OH, or esterified OH.
    Type: Grant
    Filed: November 25, 1974
    Date of Patent: February 7, 1978
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Erich Schacht, Werner Mehrhof, Zdenek Simane, Herbert Nowak, Detlev Kayser
  • Patent number: 4069338
    Abstract: Indole derivatives of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are identical or different and each is H or alkyl of 1 - 6 carbon atoms, R.sup.4 is H or methyl and R.sup.5 is methyl, phenyl or chlorophenyl, and their physiologically acceptable salts, are blood cholesterol-lowering agents.
    Type: Grant
    Filed: April 13, 1976
    Date of Patent: January 17, 1978
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Erich Schacht, Werner Mehrhof, Detlev Kayser, Zdenek Simane
  • Patent number: 4053626
    Abstract: Phenoxyacetic acids of the formula ##STR1## wherein R.sub.1 is H or alkyl of 1-4 carbon atoms; R.sub.2 is H, or when R.sub.4 is Q, also alkyl of 1-4 carbon atoms; R.sub.3 is methyl, phenyl or chlorophenyl; and R.sub.4 is piperidino, isoindolino, 1,2,3,4-tetrahydroquinolino, 1-R.sub.5 -1,2,3,4-tetrahydro-4-quinolyl, 4-piperidinophenyl, 4-piperidinophenoxy, 1-pyrryl, or Q, wherein R.sub.5 is H or alkyl of 1-4 carbon atoms; and Q is 4-oxo-1,2,3,4-tetrahydroquinolino, 4-hydroxy-1,2,3,4-tetrahydroquinolino, 4-chromanyl, 4-thiochromanyl or 1-phenyl-1,2,3,4-tetrahydro-4-quinolyl; and the salts thereof, possess cholesterol level-lowering activity.
    Type: Grant
    Filed: September 17, 1976
    Date of Patent: October 11, 1977
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Erich Schacht, Werner Mehrhof, Herbert Nowak, Zdenek Simane, Detlev Kayser
  • Patent number: 4051170
    Abstract: Diphenoxyacetic acid derivatives of the general formula ##STR1## wherein R.sub.1 is H or alkyl of 1-4 carbon atoms, R.sub.2 is H or Cl, R.sub.2 is H or Cl, R.sub.3 is piperidino, 4-piperidinophenyl, 1,2,3,4-tetrahydroquinolino, 1-R.sub.4 -1,2,3,4-tetrahydro-4-quinolyl, 4-oxo-1,2,3,4-tetrahydroquinolino, 4-chromanyl, 4-thiochromanyl or 4-chlorophenoxy, and R.sub.4 is H or alkyl of 1-4 carbon atoms, and the physiologically acceptable salts thereof, possess cholesterol level lowering activity and can be prepared by reacting a phenol of the formula ##STR2## with a compound of the formula ##STR3## wherein X is OH, esterified OH, Cl, Br or I, one R is R.sub.2 and the other is R.sub.3 ; or by cyclizing a compound of the formula ##STR4## wherein X.sub.1 is Cl, Br, I, NH.sub.2 OH or an esterified or etherified OH-group and n is 0 or 1; or by treating a compound of the formula ##STR5## wherein Z is a functionally modified carboxyl group different from COOR.sub.1, with a solvolyzing agent, R.sub.1, R.sub.2 and R.sub.
    Type: Grant
    Filed: December 11, 1974
    Date of Patent: September 27, 1977
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Erich Schacht, Werner Mehrhof, Zdenek Simane, Detlev Kayser, Herbert Nowak
  • Patent number: 3992386
    Abstract: Phenoxyacetic acids of the formula ##SPC1##Wherein R.sub.1 is H or alkyl of 1-4 carbon atoms; R.sub.2 is H, or when R.sub.4 is Q, also alkyl of 1-4 carbon atoms; R.sub.3 is methyl, phenyl or chlorophenyl; and R.sub.4 is piperidino, isoindolino, 1,2,3,4-tetrahydroquinolino, 1-R.sub.5 -1,2,3,4-tetrahydro-4-quinolyl, 4-piperidinophenyl, 4-piperidinophenoxy, 1-pyrryl, or Q, wherein R.sub.5 is H or alkyl of 1-4 carbon atoms; and Q is 4-oxo-1,2,3,4-tetrahydroquinolino, 4-hydroxy-1,2,3,4-tetrahydroquinolino, 4-chromanyl, 4-thiochromanyl or 1-phenyl-1,2,3,4-tetrahydro-4-quinolyl; and the salts thereof, possess cholesterol level-lowering activity.
    Type: Grant
    Filed: March 8, 1974
    Date of Patent: November 16, 1976
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Erich Schacht, Werner Mehrhof, Herbert Nowak, Zdenek Simane, Detlev Kayser