Patents by Inventor Dev P. Arya
Dev P. Arya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10203334Abstract: Small molecule fluorescent probes for established drug targets such as nucleic acids including DNA and RNA has been developed and disclosed herein. These nucleic acid probes bind to multiple DNA and RNA structures, and to sites crucial for nucleic acid function, such as DNA and RNA major grooves. Displacement of the probes by other binders such as small molecule compounds and/or proteins illicits a fluorescence change in the probe that once detected and analyzed provide binding information of these other binders of interest. Similarly, changes in fluorescence upon binding of the probes to nucleic acid have been applied to screen nucleic acid of different sequence and conformation. The nucleic acid probes and method of uses disclosed herein are advantageously suitable for high-through put screening of libraries of small molecule compounds, proteins, and nucleic acids.Type: GrantFiled: March 31, 2016Date of Patent: February 12, 2019Assignee: Nubad, LLCInventors: Dev P. Arya, Frank Anderson Norris, Jason Derrick Watkins
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Patent number: 9920014Abstract: The present invention provides novel bisbenzimidazole compounds and methods of using the compounds as antibacterial agents.Type: GrantFiled: September 19, 2014Date of Patent: March 20, 2018Assignees: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES, CLEMSON UNIVERSITYInventors: Nihar Ranjan, Dev P. Arya, Fenfei Leng
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Patent number: 9492554Abstract: Disclosed herein are compounds, compositions and methods related to viral inhibition. In some forms, the compounds, compositions and methods are related to binding RNA.Type: GrantFiled: May 4, 2015Date of Patent: November 15, 2016Assignee: Clemson UniversityInventors: Dev P. Arya, Nihar Ranjan, Sunil Kumar
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Publication number: 20160282357Abstract: Small molecule fluorescent probes for established drug targets such as nucleic acids including DNA and RNA has been developed and disclosed herein. These nucleic acid probes bind to multiple DNA and RNA structures, and to sites crucial for nucleic acid function, such as DNA and RNA major grooves. Displacement of the probes by other binders such as small molecule compounds and/or proteins illicits a fluorescence change in the probe that once detected and analyzed provide binding information of these other binders of interest. Similarly, changes in fluorescence upon binding of the probes to nucleic acid have been applied to screen nucleic acid of different sequence and conformation. The nucleic acid probes and method of uses disclosed herein are advantageously suitable for high-through put screening of libraries of small molecule compounds, proteins, and nucleic acids.Type: ApplicationFiled: March 31, 2016Publication date: September 29, 2016Inventors: Dev P. Arya, Frank Anderson Norris, Jason Derrick Watkins
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Publication number: 20160263231Abstract: Disclosed herein are compounds, compositions and methods related to viral inhibition. In some forms, the compounds, compositions and methods are related to binding RNA.Type: ApplicationFiled: May 4, 2015Publication date: September 15, 2016Inventors: Dev P. Arya, Nihar Ranjan, Sunil Kumar
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Publication number: 20160229810Abstract: The present invention provides novel bisbenzimidazole compounds and methods of using the compounds as antibacterial agents.Type: ApplicationFiled: September 19, 2014Publication date: August 11, 2016Applicant: The Florida International University Board of TrusteesInventors: Nihar RANJAN, Dev P. ARYA, Fenfei LENG
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Patent number: 9410186Abstract: Small molecule fluorescent probes for established drug targets such as nucleic acids including DNA and RNA has been developed and disclosed herein. These nucleic acid probes bind to multiple DNA and RNA structures, and to sites crucial for nucleic acid function, such as DNA and RNA major grooves. Displacement of the probes by other binders such as small molecule compounds and/or proteins illicits a fluorescence change in the probe that once detected and analyzed provide binding information of these other binders of interest. Similarly, changes in fluorescence upon binding of the probes to nucleic acid have been applied to screen nucleic acid of different sequence and conformation. The nucleic acid probes and method of uses disclosed herein are advantageously suitable for high-through put screening of libraries of small molecule compounds, proteins, and nucleic acids.Type: GrantFiled: July 11, 2013Date of Patent: August 9, 2016Assignee: Nubad LLCInventors: Dev P. Arya, Frank Anderson Norris, Jason Derrick Watkins
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Patent number: 9072761Abstract: Disclosed herein are compounds, compositions and methods related to viral inhibition. In some forms, the compounds, compositions and methods are related to binding RNA.Type: GrantFiled: August 16, 2010Date of Patent: July 7, 2015Assignee: Clemson University Research Foundation (CURF)Inventors: Dev P. Arya, Nihar Ranjan, Sunil Kumar
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Patent number: 9017943Abstract: Small molecule fluorescent probes for established drug targets such as nucleic acids including DNA and RNA has been developed and disclosed herein. These nucleic acid probes bind to multiple DNA and RNA structures, and to sites crucial for nucleic acid function, such as DNA and RNA major grooves. Displacement of the probes by other binders such as small molecule compounds and/or proteins illicits a fluorescence change in the probe that once detected and analyzed provide binding information of these other binders of interest. Similarly, changes in fluorescence upon binding of the probes to nucleic acid have been applied to screen nucleic acid of different sequence and conformation. The nucleic acid probes and method of uses disclosed herein are advantageously suitable for high-through put screening of libraries of small molecule compounds, proteins, and nucleic acids.Type: GrantFiled: April 11, 2014Date of Patent: April 28, 2015Assignee: Nubad LLCInventors: Dev P. Arya, Frank Anderson Norris, Jason Derrick Watkins
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Publication number: 20140330001Abstract: Small molecule fluorescent probes for established drug targets such as nucleic acids including DNA and RNA has been developed and disclosed herein. These nucleic acid probes bind to multiple DNA and RNA structures, and to sites crucial for nucleic acid function, such as DNA and RNA major grooves. Displacement of the probes by other binders such as small molecule compounds and/or proteins illicits a fluorescence change in the probe that once detected and analyzed provide binding information of these other binders of interest. Similarly, changes in fluorescence upon binding of the probes to nucleic acid have been applied to screen nucleic acid of different sequence and conformation. The nucleic acid probes and method of uses disclosed herein are advantageously suitable for high-through put screening of libraries of small molecule compounds, proteins, and nucleic acids.Type: ApplicationFiled: April 11, 2014Publication date: November 6, 2014Applicant: Nubad, LLCInventors: Dev P. Arya, Frank Anderson Norris, Jason Derrick Watkins
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Publication number: 20140024137Abstract: Small molecule fluorescent probes for established drug targets such as nucleic acids including DNA and RNA has been developed and disclosed herein. These nucleic acid probes bind to multiple DNA and RNA structures, and to sites crucial for nucleic acid function, such as DNA and RNA major grooves. Displacement of the probes by other binders such as small molecule compounds and/or proteins illicits a fluorescence change in the probe that once detected and analyzed provide binding information of these other binders of interest. Similarly, changes in fluorescence upon binding of the probes to nucleic acid have been applied to screen nucleic acid of different sequence and conformation. The nucleic acid probes and method of uses disclosed herein are advantageously suitable for high-through put screening of libraries of small molecule compounds, proteins, and nucleic acids.Type: ApplicationFiled: July 11, 2013Publication date: January 23, 2014Inventors: Dev P. Arya, Frank Anderson Norris
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Publication number: 20110046982Abstract: Disclosed herein are compounds, compositions and methods related to viral inhibition. In some forms, the compounds, compositions and methods are related to binding RNA.Type: ApplicationFiled: August 16, 2010Publication date: February 24, 2011Applicant: CLEMSON UNIVERSITY RESEARCH FOUNDATION (CURF)Inventors: Dev P. Arya, Nihar Ranjan, Sunil Kumar
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Patent number: 6136965Abstract: The invention provides novel deoxynucleic alkyl thiourea (dNXt) oligonucleotide compounds for use in antisense or antigene therapy.Type: GrantFiled: July 2, 1999Date of Patent: October 24, 2000Assignee: The Regents of the University of CaliforniaInventors: Thomas C. Bruice, Dev P. Arya
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Patent number: 5770736Abstract: Reagents for cleaving or crosslinking of biomolecules using nondiffusible reactive intermediates and a method of using the reagents. In one embodiment, the DNA binding element includes a phenyl group on each end, and each terminal phenyl group contains at least one reactive group X: ##STR1## The reactive groups X may function to either cleave or crosslink the DNA to which the reagent is bound. Reactive groups that cleave the DNA include radical species formed by the decomposition of diazonium ions or the hydrolysis of azocarboxylates and cationic species formed, for example, by the photolysis of diazonium ions. Crosslinking moieties include nitrenes generated from the photolysis of azides.Type: GrantFiled: June 21, 1994Date of Patent: June 23, 1998Assignee: Northeastern UniversityInventors: Dev P. Arya, Theresa Ann Devlin, David Jebaratnam, Philip Warner