Patents by Inventor Devan OHST
Devan OHST has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11806440Abstract: The instant disclosure is directed to methods of improving bone-soft tissue healing using biocompatible electrospun polymer fibers. In one embodiment, a method may include locating a portion of a subject's bone, affixing a tendon or ligament to the bone using a hardware fixture, and placing a patch comprising at least one electrospun polymer fiber in physical communication with both the bone and the tendon or ligament. In some embodiments, the bone may be a humerus, and the tendon or ligament may be a supraspinatus tendon. In certain embodiments, the patch may comprise substantially parallel electrospun polymer fibers, and may be placed such that the fibers are also substantially parallel with the long axis of the tendon or ligament.Type: GrantFiled: December 22, 2020Date of Patent: November 7, 2023Assignee: NFS IP Holdings, LLCInventors: Jed K. Johnson, Devan Ohst, Jason Chakroff, Brian Cohen, Anthony Romeo
-
Publication number: 20230320998Abstract: A fiber may comprise an electrospun polymer and a pharmaceutical. The pharmaceutical may be dispersed within the electrospun polymer, and may have the form of a crystal, an oil, or a combination thereof. A method of making an electrospun fiber may comprise configuring a receiving surface to receive a polymer fiber, applying a charge to one or more of the receiving surface, a polymer injection system, and a polymer solution ejected from the polymer injection system, and depositing a polymer solution ejected from the polymer injection system onto the receiving surface. The polymer solution may comprise a polymer and a pharmaceutical. A method of treating a disorder in a subject may comprise obtaining such a fiber having an effective amount of a pharmaceutical, applying the fiber to an oral region of the subject, and allowing the fiber to disintegrate, thereby delivering the effective amount of the pharmaceutical to the subject.Type: ApplicationFiled: October 28, 2022Publication date: October 12, 2023Applicant: Nanofiber Solutions, LLCInventors: Jed JOHNSON, Katie KAFFENBARGER, Devan OHST, Ross KAYUHA
-
Publication number: 20220354779Abstract: Described herein are electrospun core-shell fibers that include (i) a central core that is electrically conductive having an exterior surface, wherein the core comprises a first polymer and an electroconductive material; (ii) a shell adjacent to the exterior surface of the core, the shell comprising a second polymer; and (iii) one or more bioactive agents in the shell. In one aspect, the fibers are electrospun fibers. Additionally, described herein are methods for making and using the core-shell fibers.Type: ApplicationFiled: September 21, 2020Publication date: November 10, 2022Inventors: Daniel Gallego-Perez, Natalia Higuita-Castro, Jed Johnson, Devan Ohst
-
Patent number: 11337705Abstract: An embolization device may include a fiber section having a plurality of polymeric electrospun fibers and, optionally, a contrast agent. An embolization device may further include a plurality of fiber sections, wherein each fiber section is separated by a linker. A method of deploying such an embolization device may include inserting the embolization device into a vessel. The method may further include applying an electrical current to one or more of the linkers, applying electrothermal heat to at least a portion of the device, or applying force to at least a portion of a delivery vehicle for the device. A method of manufacturing the device may include electrospinning a fiber section, and processing the fiber section by straining, twisting, heating, or shaping it.Type: GrantFiled: May 23, 2019Date of Patent: May 24, 2022Assignee: NANOFIBER SOLUTIONS, LLCInventors: Jed Johnson, Tyler Groehl, Devan Ohst
-
Publication number: 20220090299Abstract: Described herein are electrospun nanofiber structures and compositions configured to serve as TNT-based platforms for the delivery of an agent or cargo, such as genetic material. The structures can include a conductive nanofiber comprising a shell electrospun from an insulating polymer, wherein the shell comprises a plurality of nanochannels therethrough, a conductive element, and an agent contained within the shell. The conductive nanofiber can be configured to deliver the agent when exposed to an electric field. The agent can include a therapeutic agent, a prophylactic agent, or a diagnostic agent.Type: ApplicationFiled: September 21, 2021Publication date: March 24, 2022Applicant: Nanofiber Solutions, LLCInventors: Jed JOHNSON, Doug KAYUHA, Devan OHST
-
Publication number: 20210287045Abstract: A neural network is trained using transfer learning to analyze medical image data, including 2D, 3D, and 4D images and models. Where the target medical image data is associated with a species or problem class for which there is not sufficient labeled data available for training, the system may create enhanced training datasets by selecting labeled data from other species, and/or labeled data from different problem classes. During training and analysis, image data is chunked into portions that are small enough to obfuscate the species source, while being large enough to preserve meaningful context related to the problem class (e.g., the image portion is small enough that it can't be determined whether it is from a human or canine, but abnormal liver tissues are still identifiable). A trained checkpoint may then be used to provide automated analysis and heat mapping of input images via a cloud platform or other application.Type: ApplicationFiled: March 10, 2021Publication date: September 16, 2021Inventors: Sean Thomas Curtin, Curtis Mitchel Stewart, Ryan Matthew Gilbride, Douglas Kirkpatrick, Devan Ohst, Christopher Iovino
-
Publication number: 20210259988Abstract: Systems and methods of forming electrospun structures including pharmaceuticals are disclosed. An electrospun structure can include one or more polymers electrospun from a polymer solution comprising a pharmaceutical such that the pharmaceutical is dispersed throughout the one or more electrospun polymers. The pharmaceutical can include a cannabinoid, a phytocannabinoid, a terpene produced by a Cannabis plant, or a combination thereof. The one or more electrospun polymer are configured to degrade over a predetermined time period to deliver the pharmaceutical over the predetermined time period.Type: ApplicationFiled: February 22, 2021Publication date: August 26, 2021Applicant: NANOFIBER SOLUTIONS, LLCInventors: Jed K. JOHNSON, Katie KAFFENBARGER, Devan OHST, Ross KAYUHA
-
Publication number: 20210106720Abstract: The instant disclosure is directed to methods of improving bone-soft tissue healing using biocompatible electrospun polymer fibers. In one embodiment, a method may include locating a portion of a subject's bone, affixing a tendon or ligament to the bone using a hardware fixture, and placing a patch comprising at least one electrospun polymer fiber in physical communication with both the bone and the tendon or ligament. In some embodiments, the bone may be a humerus, and the tendon or ligament may be a supraspinatus tendon. In certain embodiments, the patch may comprise substantially parallel electrospun polymer fibers, and may be placed such that the fibers are also substantially parallel with the long axis of the tendon or ligament.Type: ApplicationFiled: December 22, 2020Publication date: April 15, 2021Applicant: NANOFIBER SOLUTIONS, LLCInventors: Jed K. JOHNSON, Devan OHST, Jason CHAKROFF, Brian COHEN, Anthony ROMEO
-
Patent number: 10953097Abstract: A fiber may comprise an electrospun polymer and a contrast agent. A method of making an electrospun fiber may comprise configuring a receiving surface to receive a polymer fiber, applying a charge to one or more of the receiving surface, a polymer injection system, and a polymer solution ejected from the polymer injection system, and depositing a polymer solution ejected from the polymer injection system onto the receiving surface. The polymer solution may comprise a polymer and a contrast agent.Type: GrantFiled: November 2, 2016Date of Patent: March 23, 2021Assignee: NANOFIBER SOLUTIONS. LLCInventors: Jed Johnson, Devan Ohst, Jason Chakroff
-
Patent number: 10898608Abstract: The instant disclosure is directed to methods of improving bone-soft tissue healing using biocompatible electrospun polymer fibers. In one embodiment, a method may include locating a portion of a subject's bone, affixing a tendon or ligament to the bone using a hardware fixture, and placing a patch comprising at least one electrospun polymer fiber in physical communication with both the bone and the tendon or ligament. In some embodiments, the bone may be a humerus, and the tendon or ligament may be a supraspinatus tendon. In certain embodiments, the patch may comprise substantially parallel electrospun polymer fibers, and may be placed such that the fibers are also substantially parallel with the long axis of the tendon or ligament.Type: GrantFiled: February 2, 2018Date of Patent: January 26, 2021Assignee: NANOFIBER SOLUTIONS, LLCInventors: Jed Johnson, Jason Chakroff, Devan Ohst, Brian Cohen, Anthony Romeo
-
Publication number: 20200245658Abstract: A cultured meat product may comprise a scaffold comprising an electro spun polymer fiber, and a population of cells. The cultured meat product may have a thickness from about 100 ?m to about 500 mm. A method of producing such a cultured meat product may comprise preparing the scaffold, placing the scaffold into a bioreactor, adding the population of cells to the bioreactor, culturing the population of cells in the bioreactor containing the scaffold for a period of time, thereby forming the cultured meat product, and removing the cultured meat product from the bioreactor. The cultured meat product may be configured to mimic the taste, texture, size, shape, and/or topography of a traditional slaughtered meat.Type: ApplicationFiled: February 3, 2020Publication date: August 6, 2020Applicant: NANOFIBER SOLUTIONS, LLCInventors: Jed K. JOHNSON, Devan OHST
-
Publication number: 20190374227Abstract: An embolization device may include a fiber section having a plurality of polymeric electrospun fibers and, optionally, a contrast agent. An embolization device may further include a plurality of fiber sections, wherein each fiber section is separated by a linker. A method of deploying such an embolization device may include inserting the embolization device into a vessel. The method may further include applying an electrical current to one or more of the linkers, applying electrothermal heat to at least a portion of the device, or applying force to at least a portion of a delivery vehicle for the device. A method of manufacturing the device may include electrospinning a fiber section, and processing the fiber section by straining, twisting, heating, or shaping it.Type: ApplicationFiled: May 23, 2019Publication date: December 12, 2019Applicant: IkoNano Venture Partners, LLCInventors: Jed Johnson, Tyler Groehl, Devan Ohst
-
Publication number: 20190271098Abstract: The instant disclosure is directed to flexible electrospun fiber rods and methods of manufacturing such rods. A scaffold may comprise a flexible rod having a spiral cross-section, the flexible rod comprising electrospun polymer fibers. The electrospun polymer fibers may be substantially aligned or randomly oriented with respect to one another. The flexible rod may further comprise substantially uniformly distributed pores. The flexible rod may have a length and a diameter of a native mammalian tendon or ligament. A method of manufacturing such a scaffold may comprise forming a layer of polymer fibers on a mandrel by electrospinning, rolling the layer from a first end of the mandrel to a second end of the mandrel to form a toroid at the second end of the mandrel, and cutting the toroid off the mandrel to form a flexible rod having a spiral cross-section.Type: ApplicationFiled: March 4, 2019Publication date: September 5, 2019Applicant: NANOFIBER SOLUTIONS, LLCInventors: Jed K. JOHNSON, Devan Ohst, Michael Helterbran
-
Publication number: 20190269829Abstract: The instant disclosure is directed to devices and methods for facilitating bone growth. In one embodiment, a device may include a porous flexible tube comprising an electrospun fiber. The porous flexible tube may also comprise a closed end. The device may further comprise a filler material at least partially encased by the porous flexible tube. A method of manufacturing such a device may comprise electrospinning a polymer solution onto an end of a cylindrical mandrel to form the porous flexible tube, and removing the porous flexible tube from the end of the cylindrical mandrel. A method of facilitating bone growth may comprise obtaining such a device, and implanting the porous flexible tube into a subject's bone defect.Type: ApplicationFiled: March 4, 2019Publication date: September 5, 2019Inventors: Jed JOHNSON, Bruce HOFER, Devan OHST
-
Patent number: 10335154Abstract: An embolization device may include a fiber section having a plurality of polymeric electrospun fibers and, optionally, a contrast agent. An embolization device may further include a plurality of fiber sections, wherein each fiber section is separated by a linker. A method of deploying such an embolization device may include inserting the embolization device into a vessel. The method may further include applying an electrical current to one or more of the linkers, applying electrothermal heat to at least a portion of the device, or applying force to at least a portion of a delivery vehicle for the device. A method of manufacturing the device may include electrospinning a fiber section, and processing the fiber section by straining, twisting, heating, or shaping it.Type: GrantFiled: September 12, 2016Date of Patent: July 2, 2019Assignee: IkoNano Venture Partners, LLCInventors: Jed Johnson, Tyler Groehl, Devan Ohst
-
Publication number: 20190175786Abstract: The instant disclosure is directed to methods of treating articular or hyaline cartilage damage or injury using biocompatible electrospun polymer fibers. Methods are also directed to treating arthritis, particularly osteoarthritis or rheumatoid arthritis, using biocompatible electrospun polymer fibers. Such methods may involve placing a patch comprising at least one electrospun polymer fiber in physical communication with the damaged cartilage. In certain embodiments, the patch may comprise substantially parallel electrospun polymer fibers.Type: ApplicationFiled: December 7, 2018Publication date: June 13, 2019Inventors: Brian S. COHEN, Anthony A. ROMEO, Jed JOHNSON, Devan OHST
-
Publication number: 20190054036Abstract: A fiber may comprise an electrospun polymer and a pharmaceutical. The pharmaceutical may be dispersed within the electrospun polymer, and may have the form of a crystal, an oil, or a combination thereof. A method of making an electrospun fiber may comprise configuring a receiving surface to receive a polymer fiber, applying a charge to one or more of the receiving surface, a polymer injection system, and a polymer solution ejected from the polymer injection system, and depositing a polymer solution ejected from the polymer injection system onto the receiving surface. The polymer solution may comprise a polymer and a pharmaceutical. A method of treating a disorder in a subject may comprise obtaining such a fiber having an effective amount of a pharmaceutical, applying the fiber to an oral region of the subject, and allowing the fiber to disintegrate, thereby delivering the effective amount of the pharmaceutical to the subject.Type: ApplicationFiled: August 17, 2018Publication date: February 21, 2019Applicant: NANOFIBER SOLUTIONS, INC.Inventors: Jed JOHNSON, Katie KAFFENBARGER, Devan OHST, Ross KAYUHA
-
Publication number: 20180221537Abstract: The instant disclosure is directed to methods of improving bone-soft tissue healing using biocompatible electrospun polymer fibers. In one embodiment, a method may include locating a portion of a subject's bone, affixing a tendon or ligament to the bone using a hardware fixture, and placing a patch comprising at least one electrospun polymer fiber in physical communication with both the bone and the tendon or ligament. In some embodiments, the bone may be a humerus, and the tendon or ligament may be a supraspinatus tendon. In certain embodiments, the patch may comprise substantially parallel electrospun polymer fibers, and may be placed such that the fibers are also substantially parallel with the long axis of the tendon or ligament.Type: ApplicationFiled: February 2, 2018Publication date: August 9, 2018Inventors: Jed JOHNSON, Jason CHAKROFF, Devan OHST, Brian COHEN, Anthony ROMEO
-
Publication number: 20180161185Abstract: The instant disclosure is directed to medical devices having a lattice framework. The lattice framework may comprise a plurality of interconnected polymeric electrospun fiber members, or may comprise one or more wires formed into a plurality of interconnected members. The lattice framework may be substantially tubular, or may have a bowtie or cone configuration. The medical devices described herein may find particular uses as stents, flow diverters, and occlusive devices. The instant disclosure is also directed to methods of making such medical devices, using electrospinning and processing techniques.Type: ApplicationFiled: December 14, 2017Publication date: June 14, 2018Inventors: McKenzie Jacob KRESSLEIN, Brandon Javier BORJA, Jed JOHNSON, Tyler Matthew GROEHL, Devan OHST, Quang Quoc TRAN, Kevin J. NELSON
-
Publication number: 20170119886Abstract: A fiber may comprise an electrospun polymer and a contrast agent. A method of making an electrospun fiber may comprise configuring a receiving surface to receive a polymer fiber, applying a charge to one or more of the receiving surface, a polymer injection system, and a polymer solution ejected from the polymer injection system, and depositing a polymer solution ejected from the polymer injection system onto the receiving surface. The polymer solution may comprise a polymer and a contrast agent.Type: ApplicationFiled: November 2, 2016Publication date: May 4, 2017Inventors: Jed JOHNSON, Devan OHST, Jason CHAKROFF