Abstract: Disclosed herein is an analgesic composition comprising a nanoparticle and/or a microparticle that comprises a charged lipid and/or a supporting lipid; where the charged lipid comprises an electrically charged group. Disclosed herein too is a method of reducing joint inflammation, swelling and/or pain in a subject, the method comprising administering a therapeutically effective amount an analgesic composition to the subject; where the analgesic composition comprises a nanoparticle and/or a microparticle that comprises a charged lipid and/or a supporting lipid; where the charged lipid comprises an electrically charged group.

Abstract: Disclosed herein is an analgesic composition comprising a therapeutically effective amount of at least one endocannabinoid, at least one cannabinoid, or a combination of the endocannabinoid and cannabinoid and at least one local anesthetic; where the 2024/130236 endocannabinoid comprises one or more endocannabinoids, one or more analogues of the endocannabinoids, one or more pharmaceutically acceptable salts of the endocannabinoid, or a combination thereof; where the cannabinoid comprises one or more cannabinoids, one or more analogues of the cannabinoids, one or more pharmaceutically acceptable salts of the cannabinoid, or a combination thereof; where at least one of the endocannabinoid or the cannabinoid is in the form of particles.