Abstract: A synthetic or recombinant human lecithin cholesterol acyltransferase (LCAT) variant is provided which comprises an LCAT enzyme having a substitution at position 114 based on the residue numbering of wild-type (WT) human LCAT [SEQ ID NO:1], wherein said variant is characterized by one or more of: (i) an esterification rate higher than the esterification rate of WT human LCAT; and/or (ii) an association with higher density lipoprotein levels as compared to subjects having WT LCAT. Also provided are vectors encoding the variant, compositions containing same, and methods of using the variant proteins and vectors for treatment of a variety of disorders associated with defective wt LCAT.

Abstract: A synthetic or recombinant human lecithin cholesterol acyltransferase (LCAT) variant is provided which comprises an LCAT enzyme having a substitution at position 114 based on the residue numbering of wild-type (WT) human LCAT [SEQ ID NO:1], wherein said variant is characterized by one or more of: (i) an esterification rate higher than the esterification rate of WT human LCAT; and/or (ii) an association with higher density lipoprotein levels as compared to subjects having WT LCAT. Also provided are vectors encoding the variant, compositions containing same, and methods of using the variant proteins and vectors for treatment of a variety of disorders associated with defective wt LCAT.

Abstract: Embodiments of the present invention are directed to a two-way data transfer and synchronization system. The data transfer and synchronization system includes a provider system and a customer system. The provider system includes a web service hosted by a web server connected to a computer network and a first database. The customer system includes a client application, connected to the computer network and a second database (e.g., SIS database). The provider system cannot read data from the second database. The client application is configured to send requests to the web service and to receive HTTP responses from the web service. The responses from the web service are executed by the client application so that changes made to the second database are also made to the first database, and vice versa.

Abstract: Embodiments of the present invention are directed to a two-way data transfer and synchronization system. The data transfer and synchronization system includes a provider system and a customer system. The provider system includes a web service hosted by a web server connected to a computer network and a first database. The customer system includes a client application, connected to the computer network and a second database (e.g., SIS database). The provider system cannot read data from the second database. The client application is configured to send requests to the web service and to receive HTTP responses from the web service. The responses from the web service are executed by the client application so that changes made to the second database are also made to the first database, and vice versa.

Abstract: Embodiments of the present invention are directed to a two-way data transfer and synchronization system. The data transfer and synchronization system includes a provider system and a customer system. The provider system includes a web service hosted by a web server connected to a computer network and a first database. The customer system includes a client application, connected to the computer network and a second database (e.g., SIS database). The provider system cannot read data from the second database. The client application is configured to send requests to the web service and to receive HTTP responses from the web service. The responses from the web service are executed by the client application so that changes made to the second database are also made to the first database, and vice versa.

Abstract: A synthetic or recombinant human lecithin cholesterol acyltransferase (LCAT) variant is provided which comprises an LCAT enzyme having a substitution at position 114 based on the residue numbering of wild-type (WT) human LCAT [SEQ ID NO:1], wherein said variant is characterized by one or more of: (i) an esterification rate higher than the esterification rate of WT human LCAT; and/or (ii) an association with higher density lipoprotein levels as compared to subjects having WT LCAT. Also provided are vectors encoding the variant, compositions containing same, and methods of using the variant proteins and vectors for treatment of a variety of disorders associated with defective wt LCAT.

Abstract: Embodiments of the present invention are directed to a two-way data transfer and synchronization system. The data transfer and synchronization system includes a provider system and a customer system. The provider system includes a web service hosted by a web server connected to a computer network and a first database. The customer system includes a client application, connected to the computer network and a second database (e.g., SIS database). The provider system cannot read data from the second database. The client application is configured to send requests to the web service and to receive HTTP responses from the web service. The responses from the web service are executed by the client application so that changes made to the second database are also made to the first database, and vice versa.