Patents by Inventor Devin Close

Devin Close has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF DETERMINING QUANTITATIVE METHYLATION DATA
    Publication number: 20250179580
    Abstract: Disclosed are methods of determining methylation status of a target nucleic acid sequence in a sample comprising determining quantitative methylation data at two or more predetermined methylation sites in the target nucleic acid sequence, wherein the target nucleic acid sequence comprises an O6-methylguanine-DNA-methyltransferase (MGMT) promoter. Disclosed are methods of treating a subject having cancer comprising determining, from a sample, quantitative methylation data at two or more predetermined methylation sites in a MGMT promoter, wherein the sample is from the subject having cancer; and treating the subject for cancer when the quantitative methylation data at two or more predetermined methylation sites is at or above a threshold.
    Type: Application
    Filed: June 13, 2024
    Publication date: June 5, 2025
    Inventors: Sabine Hellwig, Devin Close, Amy Farrington, Anna Matynia
  • FLUOROBODIES: INTRINSICALLY FLUORESCENT BINDING LIGANDS
    Publication number: 20120077960
    Abstract: Binding ligands with intrinsic fluorescence (“fluorobodies”), fluorobody libraries, and methods of preparing fluorobodies are provided. In one aspect, the invention provides fluorobodies generated from a highly stable, artificial fluorescent protein, eCGP123 and derivatives thereof.
    Type: Application
    Filed: March 12, 2010
    Publication date: March 29, 2012
    Applicant: Los Alamos National Security, LLC
    Inventors: Andrew M. Bradbury, Geoffrey S. Waldo, Csaba Kiss, Devin Close