Abstract: The present disclosure provides systems and methods for clinical guidance of genetic testing for patients via a mobile application using artificial intelligence. In an aspect, the present disclosure provides a system for enabling an operator to generate a genomic health record of a subject, comprising: a database comprising clinical indications; a communications interface in communication with a computer of the operator; and a computer processor operatively coupled to said database and the communications interface, wherein said computer processor is programmed to (i) receive a request from the computer of the operator to evaluate a clinical indication of the subject, (ii) upon receiving the request, determine genomic data relevant to the clinical indication, and (iii) generate an output, which output comprises a recommendation that said operator have the genomic data obtained for the subject.