Abstract: The invention relates to a needle delivery device comprising a device body; one or more skin pinching members attached to the device body, the skin pinching members being moveable to pinch a longitudinal fold of skin of a patient. The device also comprises a drive mechanism configured to drive a needle out of the device body and along a needle path into the longitudinal fold of skin pinched between the pinching members, and subsequently withdraw the needle, the needle path extending substantially parallel to the surface of the patient.

Abstract: The invention relates to a needle delivery device comprising a device body; one or more skin pinching members attached to the device body, the skin pinching members being moveable to pinch a longitudinal fold of skin of a patient. The device also comprises a drive mechanism configured to drive a needle out of the device body and along a needle path into the longitudinal fold of skin pinched between the pinching members, and subsequently withdraw the needle, the needle path extending substantially parallel to the surface of the patient.

Abstract: An injection device comprises a needle holder that supports a needle, and a vial holder that supports a vial. A spring urges the needle holder to move towards the vial holder but that movement is restrained by a latch until the time of use. Releasing the latch primes the device by allowing the needle holder to move, whereby a proximal end of the needle pierces a septum of the vial. The latch is preferably released by rotating an actuator. The same rotation preferably frees the needle holder and vial to be advanced axially relative to the actuator, whereby a distal end of the needle can be introduced into the skin of a subject. Compressed air from a tank may be used to drive the discharge of the vial. The air tank preferably surrounds the vial and provides a broad proximal surface, against which manual pressure can be applied to the device.

Abstract: A needle delivery device (10) comprises a needle assembly (4, 5), a drive mechanism (2, 3) and a contact member (6). The drive mechanism (2, 3) includes a drive member (2) which is linearly moveable upon rotation of the drive member (2). The contact member (6) is positioned between and abutting the needle assembly (4, 5) and the drive member (2). The contact member (6) is configured to provide only linear motion to the needle assembly (4, 5) upon rotation of the drive member (2) so as to drive movement of the needle assembly (4, 5) between a distal and proximal direction relative to the needle delivery device (10).

Abstract: A patch having at least first and second parts is applied to the skin to prepare the skin for a transdermal device to be applied subsequently. The second part defines the area of the skin in which the required preparation process should be carried out, either by removal of a third part to form an opening in the second part or by providing preparation means such as microneedles on the underside of the second part. The second part is then removed to leave the first part adhered to the skin, which can be used as a guide for correctly locating the transdermal device so that the working area of the device and the prepared area of the skin are in alignment.

Abstract: An adhesive patch for securing a transdermal device to the skin comprises a double-sided adhesive layer. A permeable membrane element is located in an aperture in the adhesive layer. There is a small area of overlap where the adhesive layer adheres to the membrane element to secure it against movement during application and use of the patch.

Abstract: A solid dose for insertion into the skin of a patient wherein the solid dose has a hollow core. There is also provided a solid dose carrier, a device, a method of manufacturing the solid dose and a method of delivering a solid dose transdermally to a human or animal.

Abstract: A needle delivery device (10; 100) comprises a device body (12) that has an opening (14) formed on a delivery surface (16) of the device body (12). The needle delivery device (10; 100) also includes a drive mechanism (28) which is configured to, in use, drive a needle (20; 120), at least a portion (22) of which is flexible, along a needle path (30) towards the opening (14). The needle path (30) changes direction as it reaches the opening (14). Furthermore, the needle delivery device (10; 100) includes a rigid support member (32) that is fixedly secured to the device body (12) at the opening (14). The rigid support member (32) is configured to guide the needle (20) as it leaves the opening (14) so as to prevent buckling of the needle (20; 120). The device also comprises a vial (40) for containing a pharmaceutical composition, the vial being in fluid communication with one end of the needle, wherein the vial is moveable in tandem with the needle as the needle is driven along the needle path.

Abstract: It is known to deliver drugs through the skin, i.e. transdermally, by using a needle that is used in conjunction with a device. A device (10) comprises a device body (12) which has an opening (14) for receiving a needle assembly (100) in use. The device also comprises a loading mechanism (16) which is moveable in use to receive the needle assembly (100) via the opening (14) and secure the needle assembly (100) relative to the device body (12). The loading mechanism (16) is configured to receive and secure the needle assembly (100) upon force exerted on the loading mechanism (16) in a single direction (FD1).

Abstract: The invention relates to a needle delivery device comprising a device body; one or more skin pinching members attached to the device body, the skin pinching members being moveable to pinch a longitudinal fold of skin of a patient. The device also comprises e a drive mechanism configured to drive a needle out of the device body and along a needle path into the longitudinal fold of skin pinched between the pinching members, and subsequently withdraw the needle, the needle path extending substantially parallel to the surface of the patient.

Abstract: A drug delivery device that delivers pharmacologically active substances transdermally using microneedles arranged on a belt mounted rotatably about a plurality of rollers, the microneedles having an associated drug reservoir mounted on the belt which is compressed when the needles and belt are brought into contact with the skin.

Abstract: A transdermal drug delivery device comprises needles for piercing the skin of a patient to form pores in a predefined pattern; and carriers in the same pattern that may be loaded with a drug for delivery. The carriers are applied to the pores to deliver the drug through the pores to a location beneath the surface of the skin. The carriers may remain outside the pores, be introduced into the pores after the needles have been removed, or be inserted alongside the needles while they are still in place.

Abstract: This invention relates to a device that uses microneedles to create pores in the skin of a subject and delivers the drug transdermally by inserting it into the pore as a solid or semi-solid mass alongside each needle. The device is sufficiently flexible to allow relative movement of the needle and the drug mass apart from one another. Preferably a chamber holding the drug mass comprises a relatively rigid wall to ensure that the drug remains aligned close to the needle, while an adjacent chamber holding the needle comprises a relatively flexible wall to allow lateral movement of the needle as the drug is inserted alongside it.

Abstract: An injector device comprises a needle support member for supporting a distal end of a needle within a collar region of the device. On insertion of the neck of a drug cartridge into the collar region, the tip of the needle pierces a septum in the drug cartridge and is thereafter supported by the septum. The needle support member is then displaced by the drug cartridge as it moves further into the collar region. The displacement may comprise hinging or sliding of the support member. By supporting the needle as it pierces the septum and by providing controlled resistance to rapid or violent insertion of the drug cartridge, the needle support member enables a single, fine needle to be used for both the distal end and the proximal end without buckling, even if the needle is curved so that the two ends are mutually inclined.

Abstract: Irregular, angular particles are produced by a manufacturing method that comprises forming a film on a substrate and then stretching the substrate along one or more axes to fracture the film into particle structures. The substrate may be moved continuously along a production line as the film is formed and may be stretched by accelerating that movement. The substrate may comprise a surface with elevated patterns to control the fracturing of the film. The particles are particularly suitable for the transdermal delivery of a biologically active substance into the body of a patient.

Abstract: A sensor provides a measurement of an analyte such as glucose in a sample via a competitive binding FRET assay. A multi-wavelength radiation source comprises two or more distinct wavelengths such that at least two of the wavelengths are within the absorption band of the fluorescent energy donor of the FRET assay and at least one of those wavelengths is also within the absorption band of the energy acceptor of the FRET assay, giving rise to the phenomenon of spectral bleed-through. Because the degree of bleed-through varies with excitation wavelength, the multi-wavelength source allows the sensor to provide multiple measurement channels, which can be used to reduce errors in the analyte measurement.

Abstract: A solid dose for insertion into the skin of a patient wherein the solid dose has a hollow core. There is also provided a solid dose carrier, a device, a method of manufacturing the solid dose and a method of delivering a solid dose transdermally to a human or animal.

Abstract: A solid dose for insertion into the skin of a patient wherein the solid dose has a hollow core. There is also provided a solid dose carrier, a device, a method of manufacturing the solid dose and a method of delivering a solid dose transdermally to a human or animal.

Abstract: It is known to deliver drugs through the skin, i.e. transdermally, by using a needle that is used in conjunction with a device. A device (10), for delivering a needle (110) to an injection site, comprises a rotation member (12) which is rotatable about a reference axis (Aref), the reference axis (Aref) being the central axis of the rotation member (12). The device (10) further including a needle support member (14) which is configured to support a needle (110) in use. The needle support member (14) being fixedly secured to the rotation member (12) such that rotation of the rotation member (12) results in the needle (110) supported by the needle support member (14) in use being delivered to an injection site. The central axis (AOffSet) of the needle support member (14) is parallel to the reference axis (Aref) such that the needle support member (14) is offset from the rotation member (12).

Abstract: A needle delivery device (10) comprises a needle assembly (4, 5), a drive mechanism (2, 3) and a contact member (6). The drive mechanism (2, 3) includes a drive member (2) which is linearly moveable upon rotation of the drive member (2). The contact member (6) is positioned between and abutting the needle assembly (4, 5) and the drive member (2). The contact member (6) is configured to provide only linear motion to the needle assembly (4, 5) upon rotation of the drive member (2) so as to drive movement of the needle assembly (4, 5) between a distal and proximal direction relative to the needle delivery device (10).