Abstract: A closed fixture device for replacing a single insulator and a replacement method thereof are provided, the device includes a first fixture, a second fixture, tightening assemblies and extension joints, where the first fixture and the second fixture are respectively clamped and positioned on an insulator string; a retractable bearing structure is formed by connecting two the extension joints and the tightening assemblies between the first fixture and the second fixture; and the first fixture and/or the second fixture include a main clamp and an auxiliary clamp cover and are connected by pin shafts, special-shaped articulated bolts and nuts; a center of the main clamp is a semi-circular arc body, with symmetrically arranged ear plates on both sides; the ear plates are provided with connecting holes for connecting the extension joints or the tightening assemblies; the special-shaped articulated bolts are symmetrically assembled on the main clamp.

Abstract: A compound of formula (I) capable of inhibiting plasmin activity, delaying fibrinolysis, and having coagulation and hemostatic activity, pharmaceutically acceptable salts, hydrates, isomers, prodrugs and mixtures thereof, wherein X, and R1 to R5 are as defined in the description.

Abstract: Disclosed are a macrocyclic fluorine-containing heterocyclic derivative of formula (I), a preparation method thereof, and a use thereof in treatment of TRK kinase-mediated diseases.

Abstract: An electrical contactor including first and second stationary contacts, a movable contact disposed on a first end of a movable shaft that extends through a core and that is connected at a second end to an armature, an electromagnet coil surrounding the core, a first magnetic latching element disposed on the movable shaft, and a second magnetic latching element disposed adjacent the first and second stationary contacts, wherein, when the electromagnetic coil is energized, the core attracts the armature, thereby moving the movable shaft and bringing the movable contact into engagement with the first and second stationary contacts to allow electrical current to flow therebetween, wherein the electrical current induces a magnetic flux in the first and second magnetic latching elements, whereby the first and second magnetic latching elements are magnetized and are attracted to one another.

Abstract: The present application relates to a compound represented by formula (I) and used for regulating and controlling the 15-PGDH activity and an application thereof in the pharmaceutical field. The present application further provides a method for preparing the compound of the present application, a composition comprising the compound of the present application, and a pharmaceutical use of the compound in serving as a 15-PGDH inhibitor.

Abstract: A compound of formula (I) capable of inhibiting plasmin activity, delaying fibrinolysis, and having coagulation and hemostatic activity, pharmaceutically acceptable salts, hydrates, isomers, prodrugs and mixtures thereof, wherein X, and R1 to R5 are as defined in the description.

Abstract: Disclosed are a methionine adenosyltransferase inhibitor represented by formula (I), a preparation method thereof and an application thereof in the pharmaceutical field, wherein R1, R2, R3 and A are as defined in the description and claims.

Abstract: The present invention relates to a compound of formula (I) capable of inhibiting plasmin activity and having blood coagulation and hemostasis activity, and a pharmaceutically acceptable salt, hydrate, isomer, prodrug and mixture thereof, wherein R1 to R3 are as defined in the description.

Abstract: Disclosed are a macrocyclic fluorine-containing heterocyclic derivative of formula (I), a preparation method thereof, and a use thereof in treatment of TRK kinase-mediated diseases.