Patents by Inventor Dewey G. McCafferty

Dewey G. McCafferty has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL ANTIBIOTIC COMPOSITIONS AND METHODS OF MAKING OR USING THE SAME
    Publication number: 20230181684
    Abstract: The present disclosure provides methods of identifying source organisms for antibiotic agents and methods of producing novel antibiotic agents. In particular, the disclosure provides methods of identifying novel source organisms for antibiotic agents by sing functionally significant structural motifs to select probes, and mining genome sequences using the selected probes to identify suitable source organisms for production and isolation of novel antibiotic agents.
    Type: Application
    Filed: May 19, 2021
    Publication date: June 15, 2023
    Inventors: Kelsey T. MORGAN, Dewey G. MCCAFFERTY
  • Methods of treatment using arylcyclopropylamine compounds
    Patent number: 9585850
    Abstract: The present invention is directed to a method of treating Parkinson's disease using arylcyclopropylamine compounds. The arylcyclopropylamine compounds have the following formula wherein R1, R2, R3, R4, R5 and R6 are described herein.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: March 7, 2017
    Assignee: Duke University
    Inventors: Dewey G. McCafferty, Julie A. Pollock, David M. Gooden, Marc G. Caron, Raul R. Gainetdinov, Tatyana D. Sotnikova
  • METHODS OF TREATMENT USING ARYLCYCLOPROPYLAMINE COMPOUNDS
    Publication number: 20150258044
    Abstract: Described herein are methods of treating Parkinson's disease using arylcyclopropylamine compounds.
    Type: Application
    Filed: October 14, 2014
    Publication date: September 17, 2015
    Inventors: Dewey G. McCafferty, Julie A. Pollock, David M. Gooden, Marc G. Caron, Raul R. Gainetdinov, Tatyana D. Sotnikova
  • METHODS OF TREATMENT USING ARYLCYCLOPROPYLAMINE COMPOUNDS
    Publication number: 20140343118
    Abstract: Described herein are methods of treating breast cancer using arylcyclopropylamine compounds.
    Type: Application
    Filed: March 14, 2014
    Publication date: November 20, 2014
    Inventors: Dewey G. McCafferty, Sunhee Hwang, Julie A. Pollock, David M. Gooden
  • Antichlamydial agents
    Patent number: 8617563
    Abstract: An antichlamydial agent comprising an inhibitor of Chlamydial Protease-like Activity Factor (CPAF). The inhibitor of CPAF can comprise a CPAF inhibitory segment and can optionally include one or more additional residues or domains. Also provided are compositions comprising an inhibitor of CPAF, methods of identifying an inhibitor of CPAF, and methods of treating a Chlamydia infection in a subject comprising administering an inhibitor of CPAF or a composition comprising an inhibitor of CPAF to the subject.
    Type: Grant
    Filed: January 30, 2012
    Date of Patent: December 31, 2013
    Assignee: Duke University
    Inventors: Maria M. Bednar, Ine Jorgensen, Dewey G. McCafferty, Raphael H. Valdivia
  • Arylcyclopropylamines and methods of use
    Patent number: 8389580
    Abstract: Described herein are arylcyclopropylamine compounds that may inhibit enzymes comprising an amine oxidase domain, such as LSD1, MAO A and/or MAO B.
    Type: Grant
    Filed: June 2, 2010
    Date of Patent: March 5, 2013
    Assignee: Duke University
    Inventors: Dewey G. McCafferty, Julie Pollock
  • ANTICHLAMYDIAL AGENTS
    Publication number: 20120263745
    Abstract: An antichlamydial agent comprising an inhibitor of Chlamydial Protease-like Activity Factor (CPAF). The inhibitor of CPAF can comprise a CPAF inhibitory segment and can optionally include one or more additional residues or domains. Also provided are compositions comprising an inhibitor of CPAF, methods of identifying an inhibitor of CPAF, and methods of treating a Chlamydia infection in a subject comprising administering an inhibitor of CPAF or a composition comprising an inhibitor of CPAF to the subject.
    Type: Application
    Filed: January 30, 2012
    Publication date: October 18, 2012
    Inventors: Maria M. Bednar, Ine Jorgensen, Dewey G. McCafferty, Raphael H. Valdivia
  • METHODS FOR SCREENING FOR HISTONE DEACETYLASE ACTIVITY AND FOR IDENTIFYING HISTONE DEACETYLASE INHIBITORS
    Publication number: 20110300566
    Abstract: The present invention relates to novel methods for screening for histone deacetylase enzyme activity in a test sample. The present invention further relates to novel methods for screening potential inhibitors of histone deacetylase enzymes.
    Type: Application
    Filed: May 31, 2011
    Publication date: December 8, 2011
    Inventor: Dewey G. McCafferty
  • CHAPERONE-ASSISTED PROTEIN EXPRESSION AND METHODS OF USE
    Publication number: 20110086388
    Abstract: The present disclosure provides methods of utilizing chaperone proteins for the production of active protein such as those encoded by the genes of natural biosynthetic clusters. The methods provided herein have applicability for a wide variety of genes ranging from small fatty acid biosynthetic genes to large non-ribosomal peptide synthetase genes.
    Type: Application
    Filed: September 22, 2010
    Publication date: April 14, 2011
    Inventors: Dewey G. McCafferty, Amanda J. Hoertz
  • ARYLCYCLOPROPYLAMINES AND METHODS OF USE
    Publication number: 20100324147
    Abstract: Described herein are arylcyclopropylamine compounds that may inhibit enzymes comprising an amine oxidase domain, such as LSD1, MAO A and/or MAO B.
    Type: Application
    Filed: June 2, 2010
    Publication date: December 23, 2010
    Inventors: Dewey G. McCafferty, Julie Pollock
  • Antibacterial compounds and methods for treating Gram positive bacterial infections
    Patent number: 7144858
    Abstract: The present inventive subject matter relates to novel antibacterial compounds that are capable of inhibiting bacterial multiplication and killing living bacteria. The present inventive subject matter further relates to methods for treating Gram positive bacterial infections using the inventive compounds.
    Type: Grant
    Filed: June 2, 2003
    Date of Patent: December 5, 2006
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: Dewey G. McCafferty
  • Methods for screening for histone deacetylase activity and for identifying histone deacetylase inhibitors
    Publication number: 20030224473
    Abstract: The present invention relates to novel methods for screening for histone deacetylase enzyme activity in a test sample. The present invention further relates to novel methods for screening potential inhibitors of histone deacetylase enzymes.
    Type: Application
    Filed: May 23, 2003
    Publication date: December 4, 2003
    Inventor: Dewey G. McCafferty