Patents by Inventor Dexi ZHANG

Dexi ZHANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10195155
    Abstract: The present disclosure relates to a tumor-targeted drug delivery system, comprising a tumor-targeted drug carrier and a tumor-treating drug, wherein the tumor-targeted drug carrier comprises full heavy-chain human ferritin. The present disclosure also relates to a method for preparing the tumor-targeted drug delivery system comprising: depolymerizing a polymerized full heavy-chain human ferritin; adding a tumor-treating drug to the depolymerized full heavy-chain human ferritin so as to bind the tumor-treating drug to the depolymerized full heavy-chain human ferritin; and re-polymerizing the depolymerized full heavy-chain human ferritin bound with the tumor-treating drug to form a nanoparticle.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: February 5, 2019
    Assignee: Institute of Biophysics, Chinese Academy of Sciences
    Inventors: Xiyun Yan, Kelong Fan, Minmin Liang, Fei Wang, Demin Duan, Dexi Zhang, Jing Feng, Dongling Yang
  • Publication number: 20170189343
    Abstract: The present disclosure relates to a tumor-targeted drug delivery system, comprising a tumor-targeted drug carrier and a tumor-treating drug, wherein the tumor-targeted drug carrier comprises full heavy-chain human ferritin. The present disclosure also relates to a method for preparing the tumor-targeted drug delivery system comprising: depolymerizing a polymerized full heavy-chain human ferritin; adding a tumor-treating drug to the depolymerized full heavy-chain human ferritin so as to bind the tumor-treating drug to the depolymerized full heavy-chain human ferritin; and re-polymerizing the depolymerized full heavy-chain human ferritin bound with the tumor-treating drug to form a nanoparticle.
    Type: Application
    Filed: September 24, 2014
    Publication date: July 6, 2017
    Applicant: Institute of Biophysics, Chinese Academy of Sciences
    Inventors: Xiyun Yan, Kelong Fan, Minmin Liang, Fei Wang, Demin Duan, Dexi Zhang, Jing Feng, Dongling Yang
  • Publication number: 20160334397
    Abstract: This invention provides a nanozyme immunochromatographic detection method for detecting a substance to be tested in a liquid sample, comprising, in this order, the steps of: 1) providing a detection probe, which is prepared by coupling a magnetic nanoparticle to a first molecule capable of specifically binding to the substance to be tested; 2) providing a capture probe, which is an immobilized second molecule capable of specifically binding to the substance to be tested; 3) bringing the liquid sample into contact with the detection probe; 4) bringing the liquid sample, which has been in contact with the detection probe, into contact with the capture probe; and 5) adding a hydrogen-donor substrate and a peroxide to the capture probe subject to the step 4) so as to perform color development reaction. This invention further provides a nanozyme immunochromatographic detection apparatus for detecting a substance to be tested in a liquid sample.
    Type: Application
    Filed: October 14, 2014
    Publication date: November 17, 2016
    Inventors: Xiyun YAN, Demin DUAN, Dexi ZHANG, Dongling YANG, Jing FENG, Jianbin SANG