Abstract: A ground-high altitude platform-satellite (G-H-S) laser communication system and method based on anisotropic non-Kolmogorov turbulence are provided, and the system includes a ground transmitting terminal, a HAP, a satellite terminal, a ground-HAP uplink and an HAP-satellite uplink. When laser beams are transmitted upwards from the ground transmitting terminal and through the HAP, the laser beams are affected light intensity scintillation, beam drift, and angle of arrival fluctuation, and are transmitted through vacuum channels and received by receiving antenna of the satellite terminal. The HAP is located at stratosphere, and an anisotropic non-Kolmogorov turbulence model is suitable for analyzing turbulence effect in stratosphere. Thus, the anisotropic non-Kolmogorov turbulence model is used to research transmission characteristics of the laser beams.